FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103184465> ?p ?o ?g. }

• W2103184465 abstract "In the Netherlands, perinatal asphyxia (severe perinatal oxygen shortage) necessitating newborn resuscitation occurs in at least 200 of the 180-185.000 newly born infants per year. International randomized controlled trials have demonstrated an improved neurological outcome with therapeutic hypothermia. During hypothermia neonates receive sedative, analgesic, anti-epileptic and antibiotic drugs. So far little information is available how the pharmacokinetics (PK) and pharmacodynamics (PD) of these drugs are influenced by post resuscitation multi organ failure and the metabolic effects of the cooling treatment itself. As a result, evidence based dosing guidelines are lacking. This multicenter observational cohort study was designed to answer the question how hypothermia influences the distribution, metabolism and elimination of commonly used drugs in neonatal intensive care.Multicenter cohort study. All term neonates treated with hypothermia for Hypoxic Ischemic Encephalopathy (HIE) resulting from perinatal asphyxia in all ten Dutch Neonatal Intensive Care Units (NICUs) will be eligible for this study. During hypothermia and rewarming blood samples will be taken from indwelling catheters to investigate blood concentrations of several antibiotics, analgesics, sedatives and anti-epileptic drugs. For each individual drug the population PK will be characterized using Nonlinear Mixed Effects Modelling (NONMEM). It will be investigated how clearance and volume of distribution are influenced by hypothermia also taking maturation of neonate into account. Similarly, integrated PK-PD models will be developed relating the time course of drug concentration to pharmacodynamic parameters such as successful seizure treatment; pain assessment and infection clearance.On basis of the derived population PK-PD models dosing guidelines will be developed for the application of drugs during neonatal hypothermia treatment. The results of this study will lead to an evidence based drug treatment of hypothermic neonatal patients. Results will be published in a national web based evidence based paediatric formulary, peer reviewed journals and international paediatric drug references.NTR2529." @default.
• W2103184465 created "2016-06-24" @default.
• W2103184465 creator A5002413922 @default.
• W2103184465 creator A5015206545 @default.
• W2103184465 creator A5017836527 @default.
• W2103184465 creator A5018932159 @default.
• W2103184465 creator A5021986417 @default.
• W2103184465 creator A5036020162 @default.
• W2103184465 creator A5039030132 @default.
• W2103184465 creator A5042964493 @default.
• W2103184465 creator A5051496088 @default.
• W2103184465 creator A5064803155 @default.
• W2103184465 creator A5068423339 @default.
• W2103184465 creator A5069937744 @default.
• W2103184465 creator A5070480587 @default.
• W2103184465 creator A5077176003 @default.
• W2103184465 creator A5078176492 @default.
• W2103184465 creator A5087400465 @default.
• W2103184465 creator A5089442654 @default.
• W2103184465 creator A5091885878 @default.
• W2103184465 date "2012-05-22" @default.
• W2103184465 modified "2023-10-16" @default.
• W2103184465 title "Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study" @default.
• W2103184465 cites W1872204733 @default.
• W2103184465 cites W1976377445 @default.
• W2103184465 cites W1985230697 @default.
• W2103184465 cites W1985848675 @default.
• W2103184465 cites W1988756839 @default.
• W2103184465 cites W1990761883 @default.
• W2103184465 cites W1992659712 @default.
• W2103184465 cites W2014642268 @default.
• W2103184465 cites W2017632705 @default.
• W2103184465 cites W2037085141 @default.
• W2103184465 cites W2046282083 @default.
• W2103184465 cites W2046570531 @default.
• W2103184465 cites W2053224120 @default.
• W2103184465 cites W2072941576 @default.
• W2103184465 cites W2088670500 @default.
• W2103184465 cites W2089589050 @default.
• W2103184465 cites W2098951649 @default.
• W2103184465 cites W2107073476 @default.
• W2103184465 cites W2110178940 @default.
• W2103184465 cites W2115863844 @default.
• W2103184465 cites W2118568649 @default.
• W2103184465 cites W2121828657 @default.
• W2103184465 cites W2123170856 @default.
• W2103184465 cites W2148096041 @default.
• W2103184465 cites W2153511588 @default.
• W2103184465 cites W2154937725 @default.
• W2103184465 cites W2169597792 @default.
• W2103184465 cites W2197777403 @default.
• W2103184465 doi "https://doi.org/10.1186/1471-2431-12-45" @default.
• W2103184465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3358232" @default.
• W2103184465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22515424" @default.
• W2103184465 hasPublicationYear "2012" @default.
• W2103184465 type Work @default.
• W2103184465 sameAs 2103184465 @default.
• W2103184465 citedByCount "40" @default.
• W2103184465 countsByYear W21031844652013 @default.
• W2103184465 countsByYear W21031844652014 @default.
• W2103184465 countsByYear W21031844652015 @default.
• W2103184465 countsByYear W21031844652016 @default.
• W2103184465 countsByYear W21031844652017 @default.
• W2103184465 countsByYear W21031844652018 @default.
• W2103184465 countsByYear W21031844652019 @default.
• W2103184465 countsByYear W21031844652020 @default.
• W2103184465 countsByYear W21031844652021 @default.
• W2103184465 countsByYear W21031844652022 @default.
• W2103184465 countsByYear W21031844652023 @default.
• W2103184465 crossrefType "journal-article" @default.
• W2103184465 hasAuthorship W2103184465A5002413922 @default.
• W2103184465 hasAuthorship W2103184465A5015206545 @default.
• W2103184465 hasAuthorship W2103184465A5017836527 @default.
• W2103184465 hasAuthorship W2103184465A5018932159 @default.
• W2103184465 hasAuthorship W2103184465A5021986417 @default.
• W2103184465 hasAuthorship W2103184465A5036020162 @default.
• W2103184465 hasAuthorship W2103184465A5039030132 @default.
• W2103184465 hasAuthorship W2103184465A5042964493 @default.
• W2103184465 hasAuthorship W2103184465A5051496088 @default.
• W2103184465 hasAuthorship W2103184465A5064803155 @default.
• W2103184465 hasAuthorship W2103184465A5068423339 @default.
• W2103184465 hasAuthorship W2103184465A5069937744 @default.
• W2103184465 hasAuthorship W2103184465A5070480587 @default.
• W2103184465 hasAuthorship W2103184465A5077176003 @default.
• W2103184465 hasAuthorship W2103184465A5078176492 @default.
• W2103184465 hasAuthorship W2103184465A5087400465 @default.
• W2103184465 hasAuthorship W2103184465A5089442654 @default.
• W2103184465 hasAuthorship W2103184465A5091885878 @default.
• W2103184465 hasBestOaLocation W21031844651 @default.
• W2103184465 hasConcept C111113717 @default.
• W2103184465 hasConcept C112705442 @default.
• W2103184465 hasConcept C177713679 @default.
• W2103184465 hasConcept C2777288759 @default.
• W2103184465 hasConcept C2777390192 @default.
• W2103184465 hasConcept C2778080812 @default.
• W2103184465 hasConcept C2779914510 @default.
• W2103184465 hasConcept C2780164069 @default.
• W2103184465 hasConcept C2908647359 @default.
• W2103184465 hasConcept C2987404301 @default.
• W2103184465 hasConcept C42219234 @default.

• next