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- W2103184791 endingPage "688" @default.
- W2103184791 startingPage "671" @default.
- W2103184791 abstract "Elucidating the genetic basis of adaptive population divergence is a goal of central importance in evolutionary biology. In principle, it should be possible to identify chromosomal regions involved in adaptive divergence by screening genome-wide patterns of DNA polymorphism to detect the locus-specific signature of positive directional selection. In the case of spatially separated populations that inhabit different environments or sympatric populations that exploit different ecological niches, it is possible to identify loci that underlie divergently selected traits by comparing relative levels of differentiation among large numbers of unlinked markers. In this review I first address the question of whether diversifying selection on polygenic traits can be expected to produce predictable patterns of allelic variation at the underlying quantitative trait loci (QTL), and whether the locus-specific effects of selection can be reliably detected against the genome-wide backdrop of stochastic variability. I then review different approaches that have been developed to identify loci involved in adaptive population divergence and I discuss the relative merits of model-based approaches that rely on assumptions about population structure vs. model-free approaches that are based on empirical distributions of summary statistics. Finally, I consider the evolutionary and functional insights that might be gained by conducting genome scans for loci involved in adaptive population divergence." @default.
- W2103184791 created "2016-06-24" @default.
- W2103184791 creator A5026872382 @default.
- W2103184791 date "2005-01-14" @default.
- W2103184791 modified "2023-10-17" @default.
- W2103184791 title "INVITED REVIEW: Using genome scans of DNA polymorphism to infer adaptive population divergence" @default.
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