FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103185622> ?p ?o ?g. }

• W2103185622 endingPage "821" @default.
• W2103185622 startingPage "809" @default.
• W2103185622 abstract "Mammalian rods respond to single photons with a hyperpolarization of about 1 mV which is accompanied by continuous noise. Since the mammalian rod bipolar cell collects signals from 20–100 rods, the noise from the converging rods would overwhelm the single-photon signal from one rod at scotopic intensities (starlight) if the bipolar cell summed signals linearly (Baylor et al., 1984). However, it is known that at scotopic intensities the retina preserves single-photon responses (Barlow et al., 1971; Mastronarde, 1983). To explore noise summation in the rod bipolar pathway, we simulated an array of rods synaptically connected to a rod bipolar cell using a compartmental model. The performance of the circuit was evaluated with a discriminator measuring errors in photon detection as false positives and false negatives, which were compared to physiologically and psychophysically measured error rates. When only one rod was connected to the rod bipolar, a Poisson rate of 80 vesicles/s was necessary for reliable transmission of the single-photon signal. When 25 rods converged through a linear synapse the noise caused an unacceptably high false positive rate, even when either dark continuous noise or synaptic noise where completely removed. We propose that a threshold nonlinearity is provided by the mGluR6 receptor in the rod bipolar dendrite (Shiells & Falk, 1994) to yield a synapse with a noise removing mechanism. With the threshold nonlinearity the synapse removed most of the noise. These results suggest that a threshold provided by the mGluR6 receptor in the rod bipolar cell is necessary for proper functioning of the retina at scotopic intensities and that the metabotropic domains in the rod bipolar are distinct. Such a nonlinear threshold could also reduce synaptic noise for cortical circuits in which sparse signals converge." @default.
• W2103185622 created "2016-06-24" @default.
• W2103185622 creator A5075223907 @default.
• W2103185622 creator A5084891303 @default.
• W2103185622 date "1998-05-01" @default.
• W2103185622 modified "2023-10-18" @default.
• W2103185622 title "Noise removal at the rod synapse of mammalian retina" @default.
• W2103185622 cites W127391971 @default.
• W2103185622 cites W1500551892 @default.
• W2103185622 cites W150962639 @default.
• W2103185622 cites W1760520861 @default.
• W2103185622 cites W1764773484 @default.
• W2103185622 cites W1766518745 @default.
• W2103185622 cites W1770292374 @default.
• W2103185622 cites W1829900417 @default.
• W2103185622 cites W1908448863 @default.
• W2103185622 cites W1960334202 @default.
• W2103185622 cites W1965666655 @default.
• W2103185622 cites W1970892357 @default.
• W2103185622 cites W1971602201 @default.
• W2103185622 cites W1975150153 @default.
• W2103185622 cites W1982073244 @default.
• W2103185622 cites W1984120782 @default.
• W2103185622 cites W1992535975 @default.
• W2103185622 cites W2002713678 @default.
• W2103185622 cites W2003484371 @default.
• W2103185622 cites W2006599783 @default.
• W2103185622 cites W2008964647 @default.
• W2103185622 cites W2012100969 @default.
• W2103185622 cites W2018447168 @default.
• W2103185622 cites W2019136552 @default.
• W2103185622 cites W2023821656 @default.
• W2103185622 cites W2027541804 @default.
• W2103185622 cites W2029711851 @default.
• W2103185622 cites W2037923854 @default.
• W2103185622 cites W2039711456 @default.
• W2103185622 cites W2040067743 @default.
• W2103185622 cites W2041496916 @default.
• W2103185622 cites W2043641524 @default.
• W2103185622 cites W2048381454 @default.
• W2103185622 cites W2048425829 @default.
• W2103185622 cites W2048755709 @default.
• W2103185622 cites W2055261660 @default.
• W2103185622 cites W2056849354 @default.
• W2103185622 cites W2061738739 @default.
• W2103185622 cites W2062328787 @default.
• W2103185622 cites W2074364727 @default.
• W2103185622 cites W2075399105 @default.
• W2103185622 cites W2082871994 @default.
• W2103185622 cites W2084462378 @default.
• W2103185622 cites W2089205664 @default.
• W2103185622 cites W2093079903 @default.
• W2103185622 cites W2093959776 @default.
• W2103185622 cites W2103299540 @default.
• W2103185622 cites W2112540246 @default.
• W2103185622 cites W2116534762 @default.
• W2103185622 cites W2119474636 @default.
• W2103185622 cites W2120062331 @default.
• W2103185622 cites W2135155121 @default.
• W2103185622 cites W2137614665 @default.
• W2103185622 cites W2142715867 @default.
• W2103185622 cites W2148658703 @default.
• W2103185622 cites W2153811827 @default.
• W2103185622 cites W2155252391 @default.
• W2103185622 cites W2162074152 @default.
• W2103185622 cites W2169255693 @default.
• W2103185622 cites W2396699058 @default.
• W2103185622 cites W2404659340 @default.
• W2103185622 cites W2411762578 @default.
• W2103185622 cites W95685582 @default.
• W2103185622 cites W99614524 @default.
• W2103185622 doi "https://doi.org/10.1017/s0952523898155037" @default.
• W2103185622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9764523" @default.
• W2103185622 hasPublicationYear "1998" @default.
• W2103185622 type Work @default.
• W2103185622 sameAs 2103185622 @default.
• W2103185622 citedByCount "78" @default.
• W2103185622 countsByYear W21031856222012 @default.
• W2103185622 countsByYear W21031856222013 @default.
• W2103185622 countsByYear W21031856222014 @default.
• W2103185622 countsByYear W21031856222017 @default.
• W2103185622 countsByYear W21031856222018 @default.
• W2103185622 countsByYear W21031856222019 @default.
• W2103185622 countsByYear W21031856222020 @default.
• W2103185622 countsByYear W21031856222021 @default.
• W2103185622 countsByYear W21031856222022 @default.
• W2103185622 countsByYear W21031856222023 @default.
• W2103185622 crossrefType "journal-article" @default.
• W2103185622 hasAuthorship W2103185622A5075223907 @default.
• W2103185622 hasAuthorship W2103185622A5084891303 @default.
• W2103185622 hasBestOaLocation W21031856222 @default.
• W2103185622 hasConcept C115961682 @default.
• W2103185622 hasConcept C120665830 @default.
• W2103185622 hasConcept C121332964 @default.
• W2103185622 hasConcept C12554922 @default.
• W2103185622 hasConcept C127445978 @default.
• W2103185622 hasConcept C142724271 @default.
• W2103185622 hasConcept C154945302 @default.

• next