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- W2103186295 abstract "In order to provide preliminary guidance for rational antibiotic combination therapy in the clinic, a systematic review and meta-analysis was performed to evaluate the in vitro synergistic activity of polymyxins combined with other antibiotics against Acinetobacter baumannii. An extensive literature search was undertaken without restriction according to region, publication type or language. All available in vitro synergy tests on antibiotic combinations consisting of polymyxins were included. The primary outcome assessed was the in vitro activity of combination therapy on bacterial kill or inhibition. In total, 70 published studies and 31 conference proceedings reporting testing of polymyxins in combination with 11 classes consisting of 28 antibiotic types against 1484 A. baumannii strains were included in the analysis. In time-kill studies, high in vitro synergy and bactericidal activity were found for polymyxins combined with several antibiotic classes such as carbapenems and glycopeptides. Carbapenems or rifampicin combination could efficiently suppress the development of colistin resistance and displayed a >50% synergy rate against colistin-resistant strains. Synergy rates of chequerboard microdilution and Etest methods in most antibiotic combinations were generally lower than those of time-kill assays. The benefits of these antibiotic combinations should be further demonstrated by well-designed clinical studies." @default.
- W2103186295 created "2016-06-24" @default.
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- W2103186295 date "2015-01-01" @default.
- W2103186295 modified "2023-10-01" @default.
- W2103186295 title "In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis" @default.
- W2103186295 cites W1582342805 @default.
- W2103186295 cites W1628591093 @default.
- W2103186295 cites W1820765431 @default.
- W2103186295 cites W1964226118 @default.
- W2103186295 cites W1966492859 @default.
- W2103186295 cites W1966899975 @default.
- W2103186295 cites W1968460424 @default.
- W2103186295 cites W1970911875 @default.
- W2103186295 cites W1974586128 @default.
- W2103186295 cites W1975257386 @default.
- W2103186295 cites W1986923773 @default.
- W2103186295 cites W1995744925 @default.
- W2103186295 cites W2007801066 @default.
- W2103186295 cites W2012738785 @default.
- W2103186295 cites W2019445800 @default.
- W2103186295 cites W2022155825 @default.
- W2103186295 cites W2023469834 @default.
- W2103186295 cites W2023568245 @default.
- W2103186295 cites W2024040601 @default.
- W2103186295 cites W2029452886 @default.
- W2103186295 cites W2030480213 @default.
- W2103186295 cites W2033705339 @default.
- W2103186295 cites W2034248364 @default.
- W2103186295 cites W2038305694 @default.
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- W2103186295 cites W2052459767 @default.
- W2103186295 cites W2053439614 @default.
- W2103186295 cites W2055188126 @default.
- W2103186295 cites W2069730292 @default.
- W2103186295 cites W2070075069 @default.
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- W2103186295 cites W2074095899 @default.
- W2103186295 cites W2076818299 @default.
- W2103186295 cites W2076858044 @default.
- W2103186295 cites W2089666483 @default.
- W2103186295 cites W2089758940 @default.
- W2103186295 cites W2094342163 @default.
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- W2103186295 cites W2100556160 @default.
- W2103186295 cites W2113219413 @default.
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- W2103186295 cites W2125213566 @default.
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- W2103186295 cites W2139268325 @default.
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- W2103186295 cites W2141497319 @default.
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- W2103186295 cites W2148969694 @default.
- W2103186295 cites W2149472931 @default.
- W2103186295 cites W2152319178 @default.
- W2103186295 cites W2157453523 @default.
- W2103186295 cites W2157512160 @default.
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- W2103186295 cites W2160320395 @default.
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- W2103186295 doi "https://doi.org/10.1016/j.ijantimicag.2014.10.002" @default.
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