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• W2103187907 abstract "Preventing tissue-factor-(TF-) mediated systemic coagulopathy improves outcome in models of sepsis. Preventing TF-mediated pulmonary coagulopathy could attenuate ventilator-induced lung injury (VILI). We investigated the effect of relative TF deficiency on pulmonary coagulopathy and inflammation in a murine model of VILI. Heterozygous TF knockout (<svg style=vertical-align:-0.0pt;width:37.012501px; id=M1 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>−</tspan> </text> </g> </g> </svg>) mice and their wild-type (<svg style=vertical-align:-0.0pt;width:37.012501px; id=M2 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>+</tspan> </text> </g> </g> </svg>) littermates were sedated (controls) or sedated, tracheotomized, and mechanically ventilated with either low or high tidal volumes for 5 hours. Mechanical ventilation resulted in pulmonary coagulopathy and inflammation, with more injury after mechanical ventilation with higher tidal volumes. Compared with <svg style=vertical-align:-0.0pt;width:37.012501px; id=M3 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>+</tspan> </text> </g> </g> </svg> mice, <svg style=vertical-align:-0.0pt;width:37.012501px; id=M4 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>−</tspan> </text> </g> </g> </svg> mice demonstrated significantly lower pulmonary thrombin-antithrombin complex levels in both ventilation groups. There were, however, no differences in lung wet-to-dry ratio, BALF total protein levels, neutrophil influx, and lung histopathology scores between <svg style=vertical-align:-0.0pt;width:37.012501px; id=M5 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>−</tspan> </text> </g> </g> </svg> and <svg style=vertical-align:-0.0pt;width:37.012501px; id=M6 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>+</tspan> </text> </g> </g> </svg> mice. Notably, pulmonary levels of cytokines were significantly higher in <svg style=vertical-align:-0.0pt;width:37.012501px; id=M7 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>−</tspan> </text> </g> </g> </svg> as compared to <svg style=vertical-align:-0.0pt;width:37.012501px; id=M8 height=13.775 version=1.1 viewBox=0 0 37.012501 13.775 width=37.012501 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,13.775)> <g transform=translate(72,-60.98)> <text transform=matrix(1,0,0,-1,-71.95,61.03)> <tspan style=font-size: 12.50px; x=0 y=0>T</tspan> <tspan style=font-size: 12.50px; x=7.6393328 y=0>F</tspan> </text> <text transform=matrix(1,0,0,-1,-57.36,66.03)> <tspan style=font-size: 8.75px; x=0 y=0>+</tspan> <tspan style=font-size: 8.75px; x=5.99512 y=0>/</tspan> <tspan style=font-size: 8.75px; x=8.4281759 y=0>+</tspan> </text> </g> </g> </svg> mice. Systemic levels of cytokines were not altered by the relative absence of TF. TF deficiency is associated with decreased pulmonary coagulation independent of the ventilation strategy. However, relative TF deficiency does not reduce VILI and actually results in higher pulmonary levels of inflammatory mediators." @default.
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• W2103187907 title "Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice" @default.
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