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• W2103188230 abstract "La guanosina trifosfatasa pequeña Rho y su blanco Rho-cinasa desempeñan un papel importante en la regulación de la presión arterial y en la contracción de la musculatura lisa vascular. Diversos agonistas de los receptores acoplados a la proteína G de la membrana celular como, por ejemplo, la angiotensina II y la fenilefrina, activan Rho, que se transloca así hacia la membrana plasmática donde activa Rho-cinasa. Al activarse Rho-cinasa por RhoA se fosforila la fosfatasa de la cadena ligera de miosina, con lo cual esta fosfatasa es inhibida, y se favorece de esta manera la contracción de las células musculares lisas vasculares, la formación de fibras de estrés y la migración celular. Así, la activación de Rho y de Rho-cinasa tiene efectos importantes en diversas enfermedades cardiovasculares. Al disponer en la actualidad de inhibidores de esta vía de señalización, diversas enfermedades cardiovasculares (y también otras no cardiovasculares) se podrían beneficiar clínicamente, entre ellas la hipertensión arterial, la hipertensión pulmonar, el espasmo cerebral y coronario, la reestenosis postangioplastia y la disfunción eréctil. The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell membrane G protein, such as angiotensin II and phenylephrine. Once Rho is activated, it translocates to the cell membrane where it, in turn, activates Rho kinase. Activated Rho kinase phosphorylates myosin light chain phosphatase, which is then inhibited. This sequence stimulates vascular smooth muscle contraction, stress fiber formation, and cell migration. In this way, Rho and Rho kinase activation have important effects on several cardiovascular diseases. Currently available substances that specifically inhibit this signaling pathway could offer clinical benefits in several cardiovascular, as well as non-cardiovascular, diseases, such as arterial hypertension, pulmonary hypertension, cerebral or coronary spasm, post-angioplasty restenosis, and erectile dysfunction." @default.
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• W2103188230 date "2005-08-01" @default.
• W2103188230 modified "2023-10-12" @default.
• W2103188230 title "La vía de señalización Rho/Rho-cinasa en la enfermedad y el remodelado cardiovascular" @default.
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• W2103188230 doi "https://doi.org/10.1157/13078132" @default.
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