FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103189959> ?p ?o ?g. }

• W2103189959 endingPage "H332" @default.
• W2103189959 startingPage "H319" @default.
• W2103189959 abstract "The present study tested the hypotheses that 1) short-term dietary deficiency (MgD) of magnesium (21 days) would result in the upregulation of ceramide synthase (CS) in left ventricular (LV), right ventricular, atrial, and aortic smooth muscle, as well as induce a synthesis/release of select cytokines and chemokines into the LV and aortic smooth muscle and serum; 2) exposure of primary cultured vascular smooth muscle cells (VSMCs) to low extracellular Mg concentration would lead to the synthesis/release of select cytokines/chemokines, activation of N-SMase, and the de novo synthesis of ceramide; and 3) inhibition of CS by fumonisin B1 (FB1) or inhibition of neutral sphingomyelinase (N-SMase) by scyphostatin (SCY) in VSMCs exposed to low Mg would result in reductions in the levels of the cytokines/chemokines and lowered levels of ceramide concomitant with inhibition of NF-κB activation. The data indicated that short-term MgD (10% normal dietary intake) resulted in the upregulation of CS in ventricular, atrial, and aortic smooth muscles coupled to the synthesis/release of 12 different cytokines/chemokines, as well as activation of NF-κB in the LV and aortic smooth muscle and sera; even very low levels of water-borne Mg (e.g., 15 mg·l −1 ·day −1 ) either prevented or ameliorated the upregulation and synthesis of the cytokines/chemokines. Our experiments also showed that VSMCs exposed to low extracellular Mg resulted in the synthesis of 5 different cytokines and chemokines concomitant with synthesis/release of ceramide. However, inhibition of the synthesis and release of ceramide by either FB1 or SCY attenuated, markedly , the generation of ceramide, release of the cytokines/chemokines, and activation of NF-κB (as measured by activated p65 and cRel)." @default.
• W2103189959 created "2016-06-24" @default.
• W2103189959 creator A5002673572 @default.
• W2103189959 creator A5008014219 @default.
• W2103189959 creator A5012953142 @default.
• W2103189959 creator A5013614593 @default.
• W2103189959 creator A5027951554 @default.
• W2103189959 creator A5028220478 @default.
• W2103189959 creator A5036897945 @default.
• W2103189959 creator A5073396860 @default.
• W2103189959 date "2012-01-01" @default.
• W2103189959 modified "2023-10-18" @default.
• W2103189959 title "Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg²⁺, NF-κB, and de novo ceramide" @default.
• W2103189959 cites W102942757 @default.
• W2103189959 cites W137152135 @default.
• W2103189959 cites W146176651 @default.
• W2103189959 cites W1535433473 @default.
• W2103189959 cites W1542941723 @default.
• W2103189959 cites W181217272 @default.
• W2103189959 cites W1930427087 @default.
• W2103189959 cites W1970742635 @default.
• W2103189959 cites W1982533264 @default.
• W2103189959 cites W1983279916 @default.
• W2103189959 cites W1984142578 @default.
• W2103189959 cites W1984663087 @default.
• W2103189959 cites W1986086928 @default.
• W2103189959 cites W1990115856 @default.
• W2103189959 cites W1992215701 @default.
• W2103189959 cites W1993597367 @default.
• W2103189959 cites W2000823512 @default.
• W2103189959 cites W2002247915 @default.
• W2103189959 cites W2006221512 @default.
• W2103189959 cites W2008933923 @default.
• W2103189959 cites W2008960002 @default.
• W2103189959 cites W2011744007 @default.
• W2103189959 cites W2012775836 @default.
• W2103189959 cites W2017191741 @default.
• W2103189959 cites W2020454682 @default.
• W2103189959 cites W2024149904 @default.
• W2103189959 cites W2024916451 @default.
• W2103189959 cites W2025281987 @default.
• W2103189959 cites W2027632911 @default.
• W2103189959 cites W2032766057 @default.
• W2103189959 cites W2034191281 @default.
• W2103189959 cites W2034336577 @default.
• W2103189959 cites W2034546431 @default.
• W2103189959 cites W2037499071 @default.
• W2103189959 cites W2039958509 @default.
• W2103189959 cites W2041576624 @default.
• W2103189959 cites W2043192013 @default.
• W2103189959 cites W2046366184 @default.
• W2103189959 cites W2051578385 @default.
• W2103189959 cites W2053296953 @default.
• W2103189959 cites W2060610804 @default.
• W2103189959 cites W2065762055 @default.
• W2103189959 cites W2067033621 @default.
• W2103189959 cites W2068704832 @default.
• W2103189959 cites W2069921134 @default.
• W2103189959 cites W2074639523 @default.
• W2103189959 cites W2076579648 @default.
• W2103189959 cites W2088327605 @default.
• W2103189959 cites W2094375196 @default.
• W2103189959 cites W2097792029 @default.
• W2103189959 cites W2108443516 @default.
• W2103189959 cites W2108714478 @default.
• W2103189959 cites W2108779470 @default.
• W2103189959 cites W2118560029 @default.
• W2103189959 cites W2119853757 @default.
• W2103189959 cites W2121684289 @default.
• W2103189959 cites W2136281548 @default.
• W2103189959 cites W2138680073 @default.
• W2103189959 cites W2141374112 @default.
• W2103189959 cites W2144225803 @default.
• W2103189959 cites W2153804899 @default.
• W2103189959 cites W2155804165 @default.
• W2103189959 cites W2157694963 @default.
• W2103189959 cites W2165463540 @default.
• W2103189959 cites W2189437039 @default.
• W2103189959 cites W2301357924 @default.
• W2103189959 cites W2410373491 @default.
• W2103189959 cites W2411618105 @default.
• W2103189959 cites W4250380335 @default.
• W2103189959 cites W80726568 @default.
• W2103189959 doi "https://doi.org/10.1152/ajpheart.00453.2011" @default.
• W2103189959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21984552" @default.
• W2103189959 hasPublicationYear "2012" @default.
• W2103189959 type Work @default.
• W2103189959 sameAs 2103189959 @default.
• W2103189959 citedByCount "28" @default.
• W2103189959 countsByYear W21031899592012 @default.
• W2103189959 countsByYear W21031899592013 @default.
• W2103189959 countsByYear W21031899592014 @default.
• W2103189959 countsByYear W21031899592015 @default.
• W2103189959 countsByYear W21031899592016 @default.
• W2103189959 countsByYear W21031899592017 @default.
• W2103189959 countsByYear W21031899592018 @default.
• W2103189959 countsByYear W21031899592019 @default.
• W2103189959 countsByYear W21031899592021 @default.

• next