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• W2103191106 abstract "Skeletal patterns are prefigured by prechondrogenic condensation. Morphogens such as fibroblast growth factor (FGF) and sonic hedgehog (Shh) specify the skeletal patterns in limb development. However, how morphogens regulate prechondrogenic condensation has remained unclear. Recently, it was demonstrated that synchronized Adenosine triphosphate (ATP) oscillations play a critical role in prechondrogenic condensation. Thus, the present study has focused on whether ATP oscillations mediate the actions of major developmental morphogens such as FGF and Shh on prechondrogenic condensation. It has been shown that both FGF and Shh signalling promoted cellular condensation but not chondrogenic differentiation and also induced ATP oscillations. In addition, blockage of FGF and Shh signalling prevented both ATP oscillations and prechondrogenic condensation. Furthermore, it was found that inhibition of ATP oscillations suppressed FGF/Shh-induced prechondrogenic condensation. These results indicate that ATP oscillations mediate the actions of FGF and Shh signalling on prechondrogenic condensation. This study proposes that morphogens organize skeletal patterns via ATP oscillations. Copyright © 2012 John Wiley & Sons, Ltd." @default.
• W2103191106 created "2016-06-24" @default.
• W2103191106 creator A5051973710 @default.
• W2103191106 date "2012-08-07" @default.
• W2103191106 modified "2023-09-27" @default.
• W2103191106 title "ATP oscillations mediate inductive action of FGF and Shh signalling on prechondrogenic condensation" @default.
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• W2103191106 doi "https://doi.org/10.1002/cbf.2862" @default.
• W2103191106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22886426" @default.
• W2103191106 hasPublicationYear "2012" @default.
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