Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103201676> ?p ?o ?g. }
- W2103201676 endingPage "4540" @default.
- W2103201676 startingPage "4530" @default.
- W2103201676 abstract "Abstract Transplantation with 2-5 × 106 mobilized CD34+cells/kg body weight lowers transplantation costs and mortality. Mobilization is most commonly performed with recombinant human G-CSF with or without chemotherapy, but a proportion of patients/donors fail to mobilize sufficient cells. BM disease, prior treatment, and age are factors influencing mobilization, but genetics also contributes. Mobilization may fail because of the changes affecting the HSC/progenitor cell/BM niche integrity and chemotaxis. Poor mobilization affects patient outcome and increases resource use. Until recently increasing G-CSF dose and adding SCF have been used in poor mobilizers with limited success. However, plerixafor through its rapid direct blockage of the CXCR4/CXCL12 chemotaxis pathway and synergy with G-CSF and chemotherapy has become a new and important agent for mobilization. Its efficacy in upfront and failed mobilizers is well established. To maximize HSC harvest in poor mobilizers the clinician needs to optimize current mobilization protocols and to integrate novel agents such as plerixafor. These include when to mobilize in relation to chemotherapy, how to schedule and perform apheresis, how to identify poor mobilizers, and what are the criteria for preemptive and immediate salvage use of plerixafor." @default.
- W2103201676 created "2016-06-24" @default.
- W2103201676 creator A5004782158 @default.
- W2103201676 creator A5023868942 @default.
- W2103201676 creator A5053223017 @default.
- W2103201676 date "2011-10-27" @default.
- W2103201676 modified "2023-10-18" @default.
- W2103201676 title "How I treat patients who mobilize hematopoietic stem cells poorly" @default.
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