Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103204803> ?p ?o ?g. }
- W2103204803 abstract "Various synthetic chemicals released to the environment can interfere with the endocrine system of vertebrates. Many of these endocrine disrupting compounds (EDCs) exhibit estrogenic activity and can interfere with sexual development and reproductive physiology. More recently, also chemicals with different modes of action (MOAs), such as antiestrogenic, androgenic and antiandrogenic EDCs, have been shown to be present in the environment. However, to date EDC-research primarily focuses on exposure to EDCs with just one MOA, while studies examining the effects of simultaneous exposure to EDCs with different MOAs are rare, although they would reflect more real, natural exposure situations. In the present study the combined effects of estrogenic and antiestrogenic EDCs were assessed by analyzing the calling behavior of short-term exposed male Xenopus laevis. The estrogenic 17α-ethinylestradiol (EE2), and the antiestrogenic EDCs tamoxifen (TAM) and fulvestrant (ICI) were used as model substances. As previously demonstrated, sole EE2 exposure (10-10 M) resulted in significant alterations of the male calling behavior, including altered temporal and spectral parameters of the advertisement calls. Sole TAM (10-7 M, 10-8 M, 10-10 M) or ICI (10-7 M) exposure, on the other hand, did not affect any of the measured parameters. If frogs were co-exposed to EE2 (10-10 M) and TAM (10-7 M) the effects of EE2 on some parameters were abolished, but co-exposure to EE2 and ICI (10-7 M) neutralized all estrogenic effects. Thus, although EDCs with antiestrogenic MOA might not exhibit any effects per se, they can alter the estrogenic effects of EE2. Our observations demonstrate that there is need to further investigate the combined effects of EDCs with various, not only opposing, MOAs as this would reflect realistic wildlife situations." @default.
- W2103204803 created "2016-06-24" @default.
- W2103204803 creator A5014223857 @default.
- W2103204803 creator A5066529086 @default.
- W2103204803 date "2012-09-18" @default.
- W2103204803 modified "2023-10-13" @default.
- W2103204803 title "The Antiestrogens Tamoxifen and Fulvestrant Abolish Estrogenic Impacts of 17α-ethinylestradiol on Male Calling Behavior of Xenopus laevis" @default.
- W2103204803 cites W1513569516 @default.
- W2103204803 cites W1562567640 @default.
- W2103204803 cites W1587094587 @default.
- W2103204803 cites W186023825 @default.
- W2103204803 cites W1964957120 @default.
- W2103204803 cites W1965125804 @default.
- W2103204803 cites W1965885686 @default.
- W2103204803 cites W1968742062 @default.
- W2103204803 cites W1968994306 @default.
- W2103204803 cites W1973847024 @default.
- W2103204803 cites W1976954310 @default.
- W2103204803 cites W1979413406 @default.
- W2103204803 cites W1982023975 @default.
- W2103204803 cites W1982047227 @default.
- W2103204803 cites W1988817348 @default.
- W2103204803 cites W1997206976 @default.
- W2103204803 cites W1999426074 @default.
- W2103204803 cites W2000106768 @default.
- W2103204803 cites W2008067515 @default.
- W2103204803 cites W2017056542 @default.
- W2103204803 cites W2020362104 @default.
- W2103204803 cites W2021591445 @default.
- W2103204803 cites W2021631138 @default.
- W2103204803 cites W2022967791 @default.
- W2103204803 cites W2022977599 @default.
- W2103204803 cites W2025002326 @default.
- W2103204803 cites W2025257001 @default.
- W2103204803 cites W2026373645 @default.
- W2103204803 cites W2027141511 @default.
- W2103204803 cites W2036903919 @default.
- W2103204803 cites W2042582164 @default.
- W2103204803 cites W2047735796 @default.
- W2103204803 cites W2050204334 @default.
- W2103204803 cites W2052542118 @default.
- W2103204803 cites W2052822657 @default.
- W2103204803 cites W2056404763 @default.
- W2103204803 cites W2062958812 @default.
- W2103204803 cites W2064486938 @default.
- W2103204803 cites W2074903810 @default.
- W2103204803 cites W2079309250 @default.
- W2103204803 cites W2079802650 @default.
- W2103204803 cites W2085885091 @default.
- W2103204803 cites W2087786428 @default.
- W2103204803 cites W2091574149 @default.
- W2103204803 cites W2093576477 @default.
- W2103204803 cites W2095469952 @default.
- W2103204803 cites W2098424231 @default.
- W2103204803 cites W2102880496 @default.
- W2103204803 cites W2106608954 @default.
- W2103204803 cites W2119009116 @default.
- W2103204803 cites W2134378135 @default.
- W2103204803 cites W2137135755 @default.
- W2103204803 cites W2141232624 @default.
- W2103204803 cites W2149319341 @default.
- W2103204803 cites W2161550802 @default.
- W2103204803 cites W2164184330 @default.
- W2103204803 cites W2166685699 @default.
- W2103204803 cites W2168243312 @default.
- W2103204803 cites W2301483955 @default.
- W2103204803 cites W2337678230 @default.
- W2103204803 cites W2340941252 @default.
- W2103204803 cites W3203340905 @default.
- W2103204803 doi "https://doi.org/10.1371/journal.pone.0044715" @default.
- W2103204803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3445530" @default.
- W2103204803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23028589" @default.
- W2103204803 hasPublicationYear "2012" @default.
- W2103204803 type Work @default.
- W2103204803 sameAs 2103204803 @default.
- W2103204803 citedByCount "20" @default.
- W2103204803 countsByYear W21032048032013 @default.
- W2103204803 countsByYear W21032048032014 @default.
- W2103204803 countsByYear W21032048032015 @default.
- W2103204803 countsByYear W21032048032016 @default.
- W2103204803 countsByYear W21032048032017 @default.
- W2103204803 countsByYear W21032048032018 @default.
- W2103204803 countsByYear W21032048032019 @default.
- W2103204803 countsByYear W21032048032020 @default.
- W2103204803 countsByYear W21032048032021 @default.
- W2103204803 crossrefType "journal-article" @default.
- W2103204803 hasAuthorship W2103204803A5014223857 @default.
- W2103204803 hasAuthorship W2103204803A5066529086 @default.
- W2103204803 hasBestOaLocation W21032048031 @default.
- W2103204803 hasConcept C104317684 @default.
- W2103204803 hasConcept C121608353 @default.
- W2103204803 hasConcept C126322002 @default.
- W2103204803 hasConcept C134018914 @default.
- W2103204803 hasConcept C185592680 @default.
- W2103204803 hasConcept C2777176818 @default.
- W2103204803 hasConcept C2777956591 @default.
- W2103204803 hasConcept C2779535977 @default.
- W2103204803 hasConcept C2780482068 @default.
- W2103204803 hasConcept C2780862370 @default.
- W2103204803 hasConcept C2908647359 @default.