FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103204805> ?p ?o ?g. }

• W2103204805 endingPage "7628" @default.
• W2103204805 startingPage "7621" @default.
• W2103204805 abstract "A novel technology combining replication- and integration-defective human immunodeficiency virus type 1 (HIV-1) vectors with genetically modified dendritic cells was developed in order to induce T-cell immunity. We introduced the vector into dendritic cells as a plasmid DNA using polyethylenimine as the gene delivery system, thereby circumventing the problem of obtaining viral vector expression in the absence of integration. Genetically modified dendritic cells (GMDC) presented viral epitopes efficiently, secreted interleukin 12, and primed both CD4(+) and CD8(+) HIV-specific T cells capable of producing gamma interferon and exerting potent HIV-1-specific cytotoxicity in vitro. In nonhuman primates, subcutaneously injected GMDC migrated into the draining lymph node at an unprecedentedly high rate and expressed the plasmid DNA. The animals presented a vigorous HIV-specific effector cytotoxic-T-lymphocyte (CTL) response as early as 3 weeks after a single immunization, which later developed into a memory CTL response. Interestingly, antibodies did not accompany these CTL responses, indicating that GMDC can induce a pure Th1 type of immune response. Successful induction of a broad and long-lasting HIV-specific cellular immunity is expected to control virus replication in infected individuals." @default.
• W2103204805 created "2016-06-24" @default.
• W2103204805 creator A5001208756 @default.
• W2103204805 creator A5003298311 @default.
• W2103204805 creator A5007390639 @default.
• W2103204805 creator A5030463228 @default.
• W2103204805 creator A5036662114 @default.
• W2103204805 creator A5041091140 @default.
• W2103204805 creator A5055370060 @default.
• W2103204805 creator A5062465303 @default.
• W2103204805 creator A5082739497 @default.
• W2103204805 date "2001-08-15" @default.
• W2103204805 modified "2023-10-14" @default.
• W2103204805 title "Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells" @default.
• W2103204805 cites W1558015274 @default.
• W2103204805 cites W1574561647 @default.
• W2103204805 cites W1601925808 @default.
• W2103204805 cites W1603412780 @default.
• W2103204805 cites W1661544713 @default.
• W2103204805 cites W1663232976 @default.
• W2103204805 cites W1815763197 @default.
• W2103204805 cites W1965569618 @default.
• W2103204805 cites W1967621614 @default.
• W2103204805 cites W1968715002 @default.
• W2103204805 cites W1969133711 @default.
• W2103204805 cites W1981449360 @default.
• W2103204805 cites W1984961554 @default.
• W2103204805 cites W1987166893 @default.
• W2103204805 cites W1994294376 @default.
• W2103204805 cites W1995377723 @default.
• W2103204805 cites W2003444408 @default.
• W2103204805 cites W2007761469 @default.
• W2103204805 cites W2010655741 @default.
• W2103204805 cites W2017304478 @default.
• W2103204805 cites W2027196213 @default.
• W2103204805 cites W2029501967 @default.
• W2103204805 cites W2039706531 @default.
• W2103204805 cites W2041026285 @default.
• W2103204805 cites W2048999843 @default.
• W2103204805 cites W2056435027 @default.
• W2103204805 cites W2065818437 @default.
• W2103204805 cites W2068788633 @default.
• W2103204805 cites W2069929656 @default.
• W2103204805 cites W2077348914 @default.
• W2103204805 cites W2103663071 @default.
• W2103204805 cites W2114290965 @default.
• W2103204805 cites W2124969212 @default.
• W2103204805 cites W2129114331 @default.
• W2103204805 cites W2131761283 @default.
• W2103204805 cites W2134795831 @default.
• W2103204805 cites W2139620037 @default.
• W2103204805 cites W2144882745 @default.
• W2103204805 cites W2146978346 @default.
• W2103204805 cites W2151303894 @default.
• W2103204805 cites W2156110652 @default.
• W2103204805 cites W2162969248 @default.
• W2103204805 cites W2171499092 @default.
• W2103204805 cites W2177327503 @default.
• W2103204805 cites W2411407737 @default.
• W2103204805 cites W2467381269 @default.
• W2103204805 cites W4313308328 @default.
• W2103204805 cites W49920453 @default.
• W2103204805 cites W90997337 @default.
• W2103204805 doi "https://doi.org/10.1128/jvi.75.16.7621-7628.2001" @default.
• W2103204805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114997" @default.
• W2103204805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11462034" @default.
• W2103204805 hasPublicationYear "2001" @default.
• W2103204805 type Work @default.
• W2103204805 sameAs 2103204805 @default.
• W2103204805 citedByCount "54" @default.
• W2103204805 countsByYear W21032048052012 @default.
• W2103204805 countsByYear W21032048052013 @default.
• W2103204805 countsByYear W21032048052014 @default.
• W2103204805 countsByYear W21032048052017 @default.
• W2103204805 countsByYear W21032048052020 @default.
• W2103204805 countsByYear W21032048052021 @default.
• W2103204805 countsByYear W21032048052023 @default.
• W2103204805 crossrefType "journal-article" @default.
• W2103204805 hasAuthorship W2103204805A5001208756 @default.
• W2103204805 hasAuthorship W2103204805A5003298311 @default.
• W2103204805 hasAuthorship W2103204805A5007390639 @default.
• W2103204805 hasAuthorship W2103204805A5030463228 @default.
• W2103204805 hasAuthorship W2103204805A5036662114 @default.
• W2103204805 hasAuthorship W2103204805A5041091140 @default.
• W2103204805 hasAuthorship W2103204805A5055370060 @default.
• W2103204805 hasAuthorship W2103204805A5062465303 @default.
• W2103204805 hasAuthorship W2103204805A5082739497 @default.
• W2103204805 hasBestOaLocation W21032048052 @default.
• W2103204805 hasConcept C104317684 @default.
• W2103204805 hasConcept C147483822 @default.
• W2103204805 hasConcept C147969180 @default.
• W2103204805 hasConcept C154317977 @default.
• W2103204805 hasConcept C159047783 @default.
• W2103204805 hasConcept C167672396 @default.
• W2103204805 hasConcept C195616568 @default.
• W2103204805 hasConcept C202751555 @default.
• W2103204805 hasConcept C203014093 @default.
• W2103204805 hasConcept C2778170410 @default.

• next