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- W2103205080 abstract "Received: December 24, 2010 , Accepted: December 30, 2010 , Published: December 30, 2010 // The PI3K pathway is frequently activated in tumors, most commonly through p110α mutation or PTEN deletion. In contrast to p110α, p110β is oncogenic when over-expressed in the wild-type state, suggesting that its regulation by p85 is different than that of p110α. In this perspective, we summarize recent data concerning the regulation of p110β, which shows that wild-type p110β acts like an oncogenic mutant of p110α. We also discuss the significance of this altered regulation in tumor models of PTEN deletion, as well as the potential implications of the unique p110β regulation on GPCR-driven tumorigenesis.  " @default.
- W2103205080 created "2016-06-24" @default.
- W2103205080 creator A5021313288 @default.
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- W2103205080 date "2010-12-30" @default.
- W2103205080 modified "2023-09-27" @default.
- W2103205080 title "A beta version of life: p110β takes center stage" @default.
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- W2103205080 doi "https://doi.org/10.18632/oncotarget.207" @default.
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