Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103205249> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2103205249 endingPage "416" @default.
- W2103205249 startingPage "407" @default.
- W2103205249 abstract "The integrin VLA-4 has been shown to play a key role in the entry of antigen-specific T cells into the CNS during autoimmune demyelination. Treatment of animals with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, with antibodies to VLA-4 is known to suppress acute disease. In the present study, a synthetic antagonist of VLA-4 (TBC 3486) was injected subcutaneously into mice adoptively sensitized for chronic relapsing EAE. TBC 3486 was administered daily for 14 days at early (before acute signs) and late time points (during chronic disease). Early treatment led to marked delay in disease onset and reduction in clinical severity and demyelination. After termination of treatment, clinical severity remained lower than in controls for more than 1 week. TBC 3486-treated animals showing no clinical signs (at the height of disease in controls) displayed moderate levels of inflammation but little damage to myelin. Late administration of TBC 3486 to animals with chronic EAE had no effect clinically. Immunocytochemistry and Western blotting of CNS tissue from acutely treated animals supported a moderate shift toward a Th2-type cytokine profile after treatment. Thus, TBC 3486 effectively delayed and reduced the acute (but not chronic) phase of EAE, and this amelioration correlated with changes in the inflammatory molecule profile." @default.
- W2103205249 created "2016-06-24" @default.
- W2103205249 creator A5015749443 @default.
- W2103205249 creator A5019823731 @default.
- W2103205249 creator A5057467113 @default.
- W2103205249 creator A5068799586 @default.
- W2103205249 date "2003-01-10" @default.
- W2103205249 modified "2023-10-12" @default.
- W2103205249 title "Differential efficacy of a synthetic antagonist of VLA-4 during the course of chronic relapsing experimental autoimmune encephalomyelitis" @default.
- W2103205249 cites W1514064771 @default.
- W2103205249 cites W1532866158 @default.
- W2103205249 cites W1793475466 @default.
- W2103205249 cites W1967046920 @default.
- W2103205249 cites W1976778626 @default.
- W2103205249 cites W1983501640 @default.
- W2103205249 cites W1991884672 @default.
- W2103205249 cites W1994556423 @default.
- W2103205249 cites W2007840608 @default.
- W2103205249 cites W2009355727 @default.
- W2103205249 cites W2014069023 @default.
- W2103205249 cites W2018456133 @default.
- W2103205249 cites W2046369009 @default.
- W2103205249 cites W2063415880 @default.
- W2103205249 cites W2078430285 @default.
- W2103205249 cites W2086487142 @default.
- W2103205249 cites W2107498883 @default.
- W2103205249 cites W2108617074 @default.
- W2103205249 cites W2116248267 @default.
- W2103205249 cites W2123434491 @default.
- W2103205249 cites W2152883511 @default.
- W2103205249 cites W2160210221 @default.
- W2103205249 doi "https://doi.org/10.1002/jnr.10487" @default.
- W2103205249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12526029" @default.
- W2103205249 hasPublicationYear "2003" @default.
- W2103205249 type Work @default.
- W2103205249 sameAs 2103205249 @default.
- W2103205249 citedByCount "26" @default.
- W2103205249 countsByYear W21032052492014 @default.
- W2103205249 countsByYear W21032052492016 @default.
- W2103205249 countsByYear W21032052492019 @default.
- W2103205249 countsByYear W21032052492022 @default.
- W2103205249 crossrefType "journal-article" @default.
- W2103205249 hasAuthorship W2103205249A5015749443 @default.
- W2103205249 hasAuthorship W2103205249A5019823731 @default.
- W2103205249 hasAuthorship W2103205249A5057467113 @default.
- W2103205249 hasAuthorship W2103205249A5068799586 @default.
- W2103205249 hasConcept C126322002 @default.
- W2103205249 hasConcept C203014093 @default.
- W2103205249 hasConcept C2776914184 @default.
- W2103205249 hasConcept C2777899865 @default.
- W2103205249 hasConcept C2778486448 @default.
- W2103205249 hasConcept C2780640218 @default.
- W2103205249 hasConcept C71924100 @default.
- W2103205249 hasConceptScore W2103205249C126322002 @default.
- W2103205249 hasConceptScore W2103205249C203014093 @default.
- W2103205249 hasConceptScore W2103205249C2776914184 @default.
- W2103205249 hasConceptScore W2103205249C2777899865 @default.
- W2103205249 hasConceptScore W2103205249C2778486448 @default.
- W2103205249 hasConceptScore W2103205249C2780640218 @default.
- W2103205249 hasConceptScore W2103205249C71924100 @default.
- W2103205249 hasIssue "3" @default.
- W2103205249 hasLocation W21032052491 @default.
- W2103205249 hasLocation W21032052492 @default.
- W2103205249 hasOpenAccess W2103205249 @default.
- W2103205249 hasPrimaryLocation W21032052491 @default.
- W2103205249 hasRelatedWork W2388688089 @default.
- W2103205249 hasRelatedWork W2733992888 @default.
- W2103205249 hasRelatedWork W3011441045 @default.
- W2103205249 hasRelatedWork W4297788265 @default.
- W2103205249 hasRelatedWork W4297788280 @default.
- W2103205249 hasRelatedWork W4297788355 @default.
- W2103205249 hasRelatedWork W4297788365 @default.
- W2103205249 hasRelatedWork W4297788431 @default.
- W2103205249 hasRelatedWork W4297788584 @default.
- W2103205249 hasRelatedWork W4297788658 @default.
- W2103205249 hasVolume "71" @default.
- W2103205249 isParatext "false" @default.
- W2103205249 isRetracted "false" @default.
- W2103205249 magId "2103205249" @default.
- W2103205249 workType "article" @default.