Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103205889> ?p ?o ?g. }
- W2103205889 endingPage "820" @default.
- W2103205889 startingPage "810" @default.
- W2103205889 abstract "An abrupt change in serum creatinine, the most common indicator of acute kidney injury (AKI), is strongly linked to poor outcomes across multiple clinical settings. Despite endless attempts to distill the magnitude and timing of a changing serum creatinine into a standardized metric, singular focus on this traditional functional marker obligates the characterization of AKI to remain, at best, retrospective and causally noninformative. The resultant inability to meaningfully segregate critical aspects of injury such as type, onset, propagation, and recovery from ongoing decrements in renal function has hindered successful translation of promising therapeutics. Over the past decade, however, the emerging field of clinical proteomics reinvigorates hope of identifying novel plasma and urine biomarkers to characterize cause and course of kidney injury. Efforts to validate these markers for use in clinical studies now show early promise but face important obstacles including interpretive difficulties inherent in using serum creatinine as a sole comparator for diagnostic performance, a need to better evaluate the incremental performance of new markers above established clinical and biochemical predictors, a relative lack of power to sufficiently examine hard clinical end points, and a potential over-reliance on use alone of receiver operating curves for assessing biomarker utility. Here, we discuss efforts to address these barriers and further ascertain the clinical value of new markers." @default.
- W2103205889 created "2016-06-24" @default.
- W2103205889 creator A5017253129 @default.
- W2103205889 creator A5034692540 @default.
- W2103205889 creator A5044924106 @default.
- W2103205889 date "2011-04-14" @default.
- W2103205889 modified "2023-10-12" @default.
- W2103205889 title "Biological Markers of Acute Kidney Injury" @default.
- W2103205889 cites W1487944809 @default.
- W2103205889 cites W1597457551 @default.
- W2103205889 cites W1934353393 @default.
- W2103205889 cites W1964405385 @default.
- W2103205889 cites W1966142961 @default.
- W2103205889 cites W1966511891 @default.
- W2103205889 cites W1966855645 @default.
- W2103205889 cites W1967300023 @default.
- W2103205889 cites W1970951370 @default.
- W2103205889 cites W1973013098 @default.
- W2103205889 cites W1977021298 @default.
- W2103205889 cites W1980218015 @default.
- W2103205889 cites W1988249798 @default.
- W2103205889 cites W1990186800 @default.
- W2103205889 cites W1991240049 @default.
- W2103205889 cites W1997548580 @default.
- W2103205889 cites W2000347404 @default.
- W2103205889 cites W2001032948 @default.
- W2103205889 cites W2002742384 @default.
- W2103205889 cites W2003143895 @default.
- W2103205889 cites W2003418600 @default.
- W2103205889 cites W2005514746 @default.
- W2103205889 cites W2006066659 @default.
- W2103205889 cites W2007193748 @default.
- W2103205889 cites W2008932022 @default.
- W2103205889 cites W2017861428 @default.
- W2103205889 cites W2018964430 @default.
- W2103205889 cites W2019526345 @default.
- W2103205889 cites W2020689357 @default.
- W2103205889 cites W2021687299 @default.
- W2103205889 cites W2022249359 @default.
- W2103205889 cites W2023991939 @default.
- W2103205889 cites W2024460661 @default.
- W2103205889 cites W2024805430 @default.
- W2103205889 cites W2025896177 @default.
- W2103205889 cites W2033597315 @default.
- W2103205889 cites W2035397803 @default.
- W2103205889 cites W2036681763 @default.
- W2103205889 cites W2036789134 @default.
- W2103205889 cites W2040624637 @default.
- W2103205889 cites W2042651836 @default.
- W2103205889 cites W2043106562 @default.
- W2103205889 cites W2043132544 @default.
- W2103205889 cites W2044344601 @default.
- W2103205889 cites W2045421375 @default.
- W2103205889 cites W2048489506 @default.
- W2103205889 cites W2051640837 @default.
- W2103205889 cites W2051908709 @default.
- W2103205889 cites W2052775360 @default.
- W2103205889 cites W2053145197 @default.
- W2103205889 cites W2056554475 @default.
- W2103205889 cites W2056557856 @default.
- W2103205889 cites W2060761887 @default.
- W2103205889 cites W2064799866 @default.
- W2103205889 cites W2074677753 @default.
- W2103205889 cites W2077472005 @default.
- W2103205889 cites W2079250582 @default.
- W2103205889 cites W2080535870 @default.
- W2103205889 cites W2084485916 @default.
- W2103205889 cites W2085039333 @default.
- W2103205889 cites W2088415931 @default.
- W2103205889 cites W2095167834 @default.
- W2103205889 cites W2099592938 @default.
- W2103205889 cites W2102265071 @default.
- W2103205889 cites W2103093342 @default.
- W2103205889 cites W2103414882 @default.
- W2103205889 cites W2104691079 @default.
- W2103205889 cites W2104801892 @default.
- W2103205889 cites W2107320405 @default.
- W2103205889 cites W2107538404 @default.
- W2103205889 cites W2109531898 @default.
- W2103205889 cites W2109983971 @default.
- W2103205889 cites W2112316403 @default.
- W2103205889 cites W2112316706 @default.
- W2103205889 cites W2113394953 @default.
- W2103205889 cites W2116803132 @default.
- W2103205889 cites W2117061717 @default.
- W2103205889 cites W2119283304 @default.
- W2103205889 cites W2121271836 @default.
- W2103205889 cites W2121894911 @default.
- W2103205889 cites W2129326184 @default.
- W2103205889 cites W2130383679 @default.
- W2103205889 cites W2131419242 @default.
- W2103205889 cites W2133685977 @default.
- W2103205889 cites W2133724024 @default.
- W2103205889 cites W2133950339 @default.
- W2103205889 cites W2136066292 @default.
- W2103205889 cites W2137982463 @default.
- W2103205889 cites W2140703380 @default.
- W2103205889 cites W2140736715 @default.