Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103206882> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2103206882 endingPage "266" @default.
- W2103206882 startingPage "259" @default.
- W2103206882 abstract "Amiodarone has been shown to interact with the nongenetically determined hepatic elimination of several drugs, including phenytoin and digoxin. Its influence on genetically determined metabolic pathways has not been studied in humans. We examined the effects of oral amiodarone therapy on the genetically determined metabolism of isoniazid (N-acetyltransferase), mephenytoin (cytochrome P450MEPH), and dextromethorphan (CYP2D6). Eight patients with arrhythmias were studied before and 76 +/- 16 days after amiodarone (loading dose of 1000 mg/day for 10 days followed by a maintenance dose of 200 to 400 mg/day). Genetically determined enzyme activity was assessed indirectly by calculating the metabolic ratio (parent drug/metabolite in 8-hour urine for CYP2D6 and P450MEPH and N-acetylisoniazid/isoniazid in plasma for N-acetyltransferase) after oral administration of the parent compounds. At the time of phenotyping, plasma concentrations of amiodarone and N-desethylamiodarone were 0.66 +/- 0.35 micrograms/ml and 0.65 +/- 0.26 micrograms/ml, respectively. Amiodarone increased the log(metabolic ratio) of dextromethorphan from a median of -2.5 (range, -2.9 to -2.0) to a median of -1.9 (range, -2.5 to -1.5; p less than 0.02) but did not alter the metabolic ratio of mephenytoin or isoniazid. The amount of dextromethorphan excreted in urine increased from a median of 0.084 mumol/8 hours (range, 0.041 to 0.161 mumol/8 hours) to a median of 0.205 mumol/8 hours (range, 0.064 to 0.288 mumol/8 hours; p less than 0.02) and the amount of its metabolite (dextrorphan) tended to decrease from a median of 26 mumol/8 hours (range, 15 to 37 mumol/8 hours) to a median of 20 mumol/8 hours (range, 7 to 27 mumol/8 hours; p less than 0.09).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2103206882 created "2016-06-24" @default.
- W2103206882 creator A5007348302 @default.
- W2103206882 creator A5027731973 @default.
- W2103206882 creator A5027760129 @default.
- W2103206882 creator A5060307669 @default.
- W2103206882 creator A5066556251 @default.
- W2103206882 creator A5067349282 @default.
- W2103206882 date "1991-09-01" @default.
- W2103206882 modified "2023-10-16" @default.
- W2103206882 title "Influence of amiodarone on genetically determined drug metabolism in humans" @default.
- W2103206882 doi "https://doi.org/10.1038/clpt.1991.135" @default.
- W2103206882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1914360" @default.
- W2103206882 hasPublicationYear "1991" @default.
- W2103206882 type Work @default.
- W2103206882 sameAs 2103206882 @default.
- W2103206882 citedByCount "21" @default.
- W2103206882 countsByYear W21032068822012 @default.
- W2103206882 countsByYear W21032068822014 @default.
- W2103206882 countsByYear W21032068822016 @default.
- W2103206882 countsByYear W21032068822018 @default.
- W2103206882 crossrefType "journal-article" @default.
- W2103206882 hasAuthorship W2103206882A5007348302 @default.
- W2103206882 hasAuthorship W2103206882A5027731973 @default.
- W2103206882 hasAuthorship W2103206882A5027760129 @default.
- W2103206882 hasAuthorship W2103206882A5060307669 @default.
- W2103206882 hasAuthorship W2103206882A5066556251 @default.
- W2103206882 hasAuthorship W2103206882A5067349282 @default.
- W2103206882 hasConcept C112705442 @default.
- W2103206882 hasConcept C126322002 @default.
- W2103206882 hasConcept C134018914 @default.
- W2103206882 hasConcept C140840227 @default.
- W2103206882 hasConcept C142724271 @default.
- W2103206882 hasConcept C185592680 @default.
- W2103206882 hasConcept C2776838488 @default.
- W2103206882 hasConcept C2776967927 @default.
- W2103206882 hasConcept C2777056448 @default.
- W2103206882 hasConcept C2777477808 @default.
- W2103206882 hasConcept C2777600422 @default.
- W2103206882 hasConcept C2778094803 @default.
- W2103206882 hasConcept C2779161974 @default.
- W2103206882 hasConcept C2779591118 @default.
- W2103206882 hasConcept C2780026642 @default.
- W2103206882 hasConcept C2781069245 @default.
- W2103206882 hasConcept C2781245242 @default.
- W2103206882 hasConcept C33664856 @default.
- W2103206882 hasConcept C526171541 @default.
- W2103206882 hasConcept C62231903 @default.
- W2103206882 hasConcept C71924100 @default.
- W2103206882 hasConcept C98274493 @default.
- W2103206882 hasConceptScore W2103206882C112705442 @default.
- W2103206882 hasConceptScore W2103206882C126322002 @default.
- W2103206882 hasConceptScore W2103206882C134018914 @default.
- W2103206882 hasConceptScore W2103206882C140840227 @default.
- W2103206882 hasConceptScore W2103206882C142724271 @default.
- W2103206882 hasConceptScore W2103206882C185592680 @default.
- W2103206882 hasConceptScore W2103206882C2776838488 @default.
- W2103206882 hasConceptScore W2103206882C2776967927 @default.
- W2103206882 hasConceptScore W2103206882C2777056448 @default.
- W2103206882 hasConceptScore W2103206882C2777477808 @default.
- W2103206882 hasConceptScore W2103206882C2777600422 @default.
- W2103206882 hasConceptScore W2103206882C2778094803 @default.
- W2103206882 hasConceptScore W2103206882C2779161974 @default.
- W2103206882 hasConceptScore W2103206882C2779591118 @default.
- W2103206882 hasConceptScore W2103206882C2780026642 @default.
- W2103206882 hasConceptScore W2103206882C2781069245 @default.
- W2103206882 hasConceptScore W2103206882C2781245242 @default.
- W2103206882 hasConceptScore W2103206882C33664856 @default.
- W2103206882 hasConceptScore W2103206882C526171541 @default.
- W2103206882 hasConceptScore W2103206882C62231903 @default.
- W2103206882 hasConceptScore W2103206882C71924100 @default.
- W2103206882 hasConceptScore W2103206882C98274493 @default.
- W2103206882 hasIssue "3" @default.
- W2103206882 hasLocation W21032068821 @default.
- W2103206882 hasLocation W21032068822 @default.
- W2103206882 hasOpenAccess W2103206882 @default.
- W2103206882 hasPrimaryLocation W21032068821 @default.
- W2103206882 hasRelatedWork W1969215912 @default.
- W2103206882 hasRelatedWork W1998494236 @default.
- W2103206882 hasRelatedWork W2000782600 @default.
- W2103206882 hasRelatedWork W2015218072 @default.
- W2103206882 hasRelatedWork W2027731572 @default.
- W2103206882 hasRelatedWork W2042632717 @default.
- W2103206882 hasRelatedWork W2049856039 @default.
- W2103206882 hasRelatedWork W2067120199 @default.
- W2103206882 hasRelatedWork W2082922601 @default.
- W2103206882 hasRelatedWork W2103206882 @default.
- W2103206882 hasVolume "50" @default.
- W2103206882 isParatext "false" @default.
- W2103206882 isRetracted "false" @default.
- W2103206882 magId "2103206882" @default.
- W2103206882 workType "article" @default.