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• W2103207718 startingPage "2461" @default.
• W2103207718 abstract "The neonatal Fc receptor, FcRn, transports proteins through cells, avoiding degradative compartments. FcRn is used in many physiological processes where proteins must remain intact while they move through cells. These contexts include the transport of IgG antibodies from mother to offspring, and the protection of IgG and albumin from catabolism. In polarized cell models, FcRn in the plasma membrane is predominantly at the basolateral surface. This distribution depends on two signals that overlap endocytosis signals. One of these signals resembles a YXXΦ motif, but with a tryptophan in place of the critical tyrosine residue; the other is a DDXXXLL signal. We examined the effects of mutations in and around these signals on the basolateral targeting of rat FcRn in rat inner medullary collecting duct cells. We also studied a second acidic cluster, Glu331/Glu333, some distance from either endocytosis signal. Some amino acid substitutions in the W–2 and W+3 positions disrupted the tryptophan-based basolateral-targeting signal without impairing its function in endocytosis. The tryptophan-based basolateral targeting and endocytosis signals are thus distinct but overlapping, as has been seen for collinear tyrosine-based signals. Surprisingly, the tryptophan-based basolateral-targeting signal required the aspartate pair of the dileucine-based signal. This acidic cluster, separated by two amino acids from the Φ residue of the tryptophan signal, is therefore a component of both of the basolateral-targeting signals. The acidic cluster Glu-331/Glu333 was not required for basolateral targeting, but its replacement reduced endocytosis." @default.
• W2103207718 created "2016-06-24" @default.
• W2103207718 creator A5013938321 @default.
• W2103207718 creator A5078554490 @default.
• W2103207718 creator A5091891160 @default.
• W2103207718 date "2005-06-01" @default.
• W2103207718 modified "2023-09-28" @default.
• W2103207718 title "Characterization of basolateral-targeting signals in the neonatal Fc receptor" @default.
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• W2103207718 doi "https://doi.org/10.1242/jcs.02367" @default.
• W2103207718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15923659" @default.
• W2103207718 hasPublicationYear "2005" @default.
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