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- W2103208539 abstract "Abstract Human effector memory (EM) CD4 T cells may be recruited from the blood into a site of inflammation in response either to inflammatory chemokines displayed on or specific Ag presented by venular endothelial cells (ECs), designated as chemokine-driven or TCR-driven transendothelial migration (TEM), respectively. We have previously described differences in the morphological appearance of transmigrating T cells as well as in the molecules that mediate T cell–EC interactions distinguishing these two pathways. In this study, we report that TCR-driven TEM requires ZAP-70–dependent activation of a pathway involving Vav, Rac, and myosin IIA. Chemokine-driven TEM also uses ZAP-70, albeit in a quantitatively and spatially different manner of activation, and is independent of Vav, Rac, and mysosin IIA, depending instead on an as-yet unidentified GTP exchange factor that activates Cdc42. The differential use of small Rho family GTPases to activate the cytoskeleton is consistent with the morphological differences observed in T cells that undergo TEM in response to these distinct recruitment signals." @default.
- W2103208539 created "2016-06-24" @default.
- W2103208539 creator A5022235365 @default.
- W2103208539 creator A5040021656 @default.
- W2103208539 date "2013-04-01" @default.
- W2103208539 modified "2023-10-11" @default.
- W2103208539 title "TCR-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells Involves Vav, Rac, and Myosin IIA" @default.
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- W2103208539 doi "https://doi.org/10.4049/jimmunol.1201817" @default.
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