FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103210188> ?p ?o ?g. }

• W2103210188 endingPage "399" @default.
• W2103210188 startingPage "390" @default.
• W2103210188 abstract "Currently available sequence alignment programs are generally not capable of detecting functional and structural homologs in the twilight zone of sequence similarity, i.e. when the sequence identity falls below about 25%. Here we attempt to detect such weak similarities using an approach based on a notion of protein sequence similarity radically different from that used in sequential alignment. The approach defines protein sequence dissimilarity (or distance) as a weighted sum of differences of compositional properties such as singlet and doublet amino acid composition, molecular weight, isoelectric point (protein property search or PropSearch). With PropSearch, either single sequences can be used for a database query, or multiple sequences can be merged into an average sequence reflecting the average composition of a protein family. First, we show that members of structural protein families have a low mutual PropSearch distance when the weights are optimized to discriminate maximally between structural families. Second, we demonstrate the results of database searches using the PropSearch method. Such searches are very rapid when scanning a preprocessed database and do not require alignments. In cases in which conventional alignment tools fail to detect similarities, PropSearch can be used to generate hypotheses about possible structural or functional relationships between a new sequence and sequences in the database." @default.
• W2103210188 created "2016-06-24" @default.
• W2103210188 creator A5008166270 @default.
• W2103210188 creator A5020335618 @default.
• W2103210188 date "1995-08-01" @default.
• W2103210188 modified "2023-09-23" @default.
• W2103210188 title "A Sequence Property Approach to Searching Protein Databases" @default.
• W2103210188 cites W1470225921 @default.
• W2103210188 cites W1503558940 @default.
• W2103210188 cites W1518578533 @default.
• W2103210188 cites W1531358660 @default.
• W2103210188 cites W1821507858 @default.
• W2103210188 cites W1849233805 @default.
• W2103210188 cites W1966041739 @default.
• W2103210188 cites W1969139842 @default.
• W2103210188 cites W1984099313 @default.
• W2103210188 cites W1992380356 @default.
• W2103210188 cites W1998852098 @default.
• W2103210188 cites W2002540607 @default.
• W2103210188 cites W2019853549 @default.
• W2103210188 cites W2022395419 @default.
• W2103210188 cites W2040703580 @default.
• W2103210188 cites W2044498524 @default.
• W2103210188 cites W2050690163 @default.
• W2103210188 cites W2054698853 @default.
• W2103210188 cites W2055043387 @default.
• W2103210188 cites W2067917889 @default.
• W2103210188 cites W2072814963 @default.
• W2103210188 cites W2081359387 @default.
• W2103210188 cites W2089499735 @default.
• W2103210188 cites W2090991561 @default.
• W2103210188 cites W2108432201 @default.
• W2103210188 cites W2110969161 @default.
• W2103210188 cites W2137995988 @default.
• W2103210188 cites W2166162901 @default.
• W2103210188 doi "https://doi.org/10.1006/jmbi.1995.0442" @default.
• W2103210188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7650738" @default.
• W2103210188 hasPublicationYear "1995" @default.
• W2103210188 type Work @default.
• W2103210188 sameAs 2103210188 @default.
• W2103210188 citedByCount "170" @default.
• W2103210188 countsByYear W21032101882012 @default.
• W2103210188 countsByYear W21032101882013 @default.
• W2103210188 countsByYear W21032101882014 @default.
• W2103210188 countsByYear W21032101882015 @default.
• W2103210188 countsByYear W21032101882016 @default.
• W2103210188 countsByYear W21032101882018 @default.
• W2103210188 countsByYear W21032101882019 @default.
• W2103210188 countsByYear W21032101882020 @default.
• W2103210188 countsByYear W21032101882021 @default.
• W2103210188 crossrefType "journal-article" @default.
• W2103210188 hasAuthorship W2103210188A5008166270 @default.
• W2103210188 hasAuthorship W2103210188A5020335618 @default.
• W2103210188 hasConcept C10010492 @default.
• W2103210188 hasConcept C103278499 @default.
• W2103210188 hasConcept C104317684 @default.
• W2103210188 hasConcept C105082737 @default.
• W2103210188 hasConcept C111472728 @default.
• W2103210188 hasConcept C115961682 @default.
• W2103210188 hasConcept C136475424 @default.
• W2103210188 hasConcept C138885662 @default.
• W2103210188 hasConcept C154945302 @default.
• W2103210188 hasConcept C167625842 @default.
• W2103210188 hasConcept C171897839 @default.
• W2103210188 hasConcept C180384323 @default.
• W2103210188 hasConcept C189950617 @default.
• W2103210188 hasConcept C2778112365 @default.
• W2103210188 hasConcept C41008148 @default.
• W2103210188 hasConcept C41584329 @default.
• W2103210188 hasConcept C45484198 @default.
• W2103210188 hasConcept C4668613 @default.
• W2103210188 hasConcept C54355233 @default.
• W2103210188 hasConcept C70721500 @default.
• W2103210188 hasConcept C77088390 @default.
• W2103210188 hasConcept C86803240 @default.
• W2103210188 hasConcept C88031987 @default.
• W2103210188 hasConceptScore W2103210188C10010492 @default.
• W2103210188 hasConceptScore W2103210188C103278499 @default.
• W2103210188 hasConceptScore W2103210188C104317684 @default.
• W2103210188 hasConceptScore W2103210188C105082737 @default.
• W2103210188 hasConceptScore W2103210188C111472728 @default.
• W2103210188 hasConceptScore W2103210188C115961682 @default.
• W2103210188 hasConceptScore W2103210188C136475424 @default.
• W2103210188 hasConceptScore W2103210188C138885662 @default.
• W2103210188 hasConceptScore W2103210188C154945302 @default.
• W2103210188 hasConceptScore W2103210188C167625842 @default.
• W2103210188 hasConceptScore W2103210188C171897839 @default.
• W2103210188 hasConceptScore W2103210188C180384323 @default.
• W2103210188 hasConceptScore W2103210188C189950617 @default.
• W2103210188 hasConceptScore W2103210188C2778112365 @default.
• W2103210188 hasConceptScore W2103210188C41008148 @default.
• W2103210188 hasConceptScore W2103210188C41584329 @default.
• W2103210188 hasConceptScore W2103210188C45484198 @default.
• W2103210188 hasConceptScore W2103210188C4668613 @default.
• W2103210188 hasConceptScore W2103210188C54355233 @default.
• W2103210188 hasConceptScore W2103210188C70721500 @default.
• W2103210188 hasConceptScore W2103210188C77088390 @default.
• W2103210188 hasConceptScore W2103210188C86803240 @default.

• next