Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103221503> ?p ?o ?g. }
- W2103221503 endingPage "2548" @default.
- W2103221503 startingPage "2541" @default.
- W2103221503 abstract "Repeated implantation failure (RIF) is a severe obstacle in human assisted reproduction treatment. Aiming to identify global gene profile in RIF patients, gene-array analyses were performed on endometrial samples collected on day 21 of the cycle from fertile women (n = 12) and from RIF patients (n = 20). Validation of cyclin E2, Slug, dickkopf homolog 1 (DKK1), lymphoid enhancer-binding factor 1 (LEF1) and secreted frizzled-related protein 1 (SFRP1) was carried out by real-time PCR. Gene-array analysis revealed 313 genes exhibiting modified expression levels in RIF patients. Of these, 288 genes (92%) were down-regulated and only 25 genes (8%) were up-regulated. Classification of the down-regulated genes to biological pathways revealed cell cycle, Wnt signaling and cellular adhesion pathways. Real-time PCR validation of cyclin E2, SFRP1 and LEF1 showed significantly lower expression levels in RIF–IVF patients as compared with fertile women. In addition, two up-regulated genes, Slug and DKK1, were also validated. Interestingly, about 8% of the down-regulated genes were estrogen-dependent. Western blot of estrogen receptor α revealed low expression of this protein in the RIF group. The evaluation of the endometrium of RIF patients by gene array analysis demonstrates that the expression of various genes is altered, including those belonging to the cell cycle, Wnt signaling and cellular adhesion pathways." @default.
- W2103221503 created "2016-06-24" @default.
- W2103221503 creator A5010813723 @default.
- W2103221503 creator A5043808246 @default.
- W2103221503 creator A5066553489 @default.
- W2103221503 creator A5077285229 @default.
- W2103221503 creator A5077653892 @default.
- W2103221503 creator A5091903672 @default.
- W2103221503 date "2009-06-19" @default.
- W2103221503 modified "2023-10-13" @default.
- W2103221503 title "Disrupted gene pattern in patients with repeated in vitro fertilization (IVF) failure" @default.
- W2103221503 cites W1968019951 @default.
- W2103221503 cites W1969768367 @default.
- W2103221503 cites W1979027856 @default.
- W2103221503 cites W1982242727 @default.
- W2103221503 cites W1987483436 @default.
- W2103221503 cites W1997408971 @default.
- W2103221503 cites W2015309809 @default.
- W2103221503 cites W2026533505 @default.
- W2103221503 cites W2035569732 @default.
- W2103221503 cites W2039837159 @default.
- W2103221503 cites W2049910117 @default.
- W2103221503 cites W2057187414 @default.
- W2103221503 cites W2058054201 @default.
- W2103221503 cites W2059226221 @default.
- W2103221503 cites W2064758929 @default.
- W2103221503 cites W2072261526 @default.
- W2103221503 cites W2080397589 @default.
- W2103221503 cites W2083888967 @default.
- W2103221503 cites W2118661243 @default.
- W2103221503 cites W2119092910 @default.
- W2103221503 cites W2121605257 @default.
- W2103221503 cites W2124156734 @default.
- W2103221503 cites W2132029697 @default.
- W2103221503 cites W2150698576 @default.
- W2103221503 cites W2155554726 @default.
- W2103221503 cites W2157223292 @default.
- W2103221503 cites W2166355223 @default.
- W2103221503 cites W2167149070 @default.
- W2103221503 cites W2204640292 @default.
- W2103221503 cites W2886180915 @default.
- W2103221503 cites W4239383155 @default.
- W2103221503 cites W4238217210 @default.
- W2103221503 doi "https://doi.org/10.1093/humrep/dep193" @default.
- W2103221503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19542175" @default.
- W2103221503 hasPublicationYear "2009" @default.
- W2103221503 type Work @default.
- W2103221503 sameAs 2103221503 @default.
- W2103221503 citedByCount "111" @default.
- W2103221503 countsByYear W21032215032012 @default.
- W2103221503 countsByYear W21032215032013 @default.
- W2103221503 countsByYear W21032215032014 @default.
- W2103221503 countsByYear W21032215032015 @default.
- W2103221503 countsByYear W21032215032016 @default.
- W2103221503 countsByYear W21032215032017 @default.
- W2103221503 countsByYear W21032215032018 @default.
- W2103221503 countsByYear W21032215032019 @default.
- W2103221503 countsByYear W21032215032020 @default.
- W2103221503 countsByYear W21032215032021 @default.
- W2103221503 countsByYear W21032215032022 @default.
- W2103221503 countsByYear W21032215032023 @default.
- W2103221503 crossrefType "journal-article" @default.
- W2103221503 hasAuthorship W2103221503A5010813723 @default.
- W2103221503 hasAuthorship W2103221503A5043808246 @default.
- W2103221503 hasAuthorship W2103221503A5066553489 @default.
- W2103221503 hasAuthorship W2103221503A5077285229 @default.
- W2103221503 hasAuthorship W2103221503A5077653892 @default.
- W2103221503 hasAuthorship W2103221503A5091903672 @default.
- W2103221503 hasBestOaLocation W21032215031 @default.
- W2103221503 hasConcept C104317684 @default.
- W2103221503 hasConcept C137620995 @default.
- W2103221503 hasConcept C150194340 @default.
- W2103221503 hasConcept C153911025 @default.
- W2103221503 hasConcept C2777491412 @default.
- W2103221503 hasConcept C29537977 @default.
- W2103221503 hasConcept C54355233 @default.
- W2103221503 hasConcept C86803240 @default.
- W2103221503 hasConcept C95444343 @default.
- W2103221503 hasConceptScore W2103221503C104317684 @default.
- W2103221503 hasConceptScore W2103221503C137620995 @default.
- W2103221503 hasConceptScore W2103221503C150194340 @default.
- W2103221503 hasConceptScore W2103221503C153911025 @default.
- W2103221503 hasConceptScore W2103221503C2777491412 @default.
- W2103221503 hasConceptScore W2103221503C29537977 @default.
- W2103221503 hasConceptScore W2103221503C54355233 @default.
- W2103221503 hasConceptScore W2103221503C86803240 @default.
- W2103221503 hasConceptScore W2103221503C95444343 @default.
- W2103221503 hasIssue "10" @default.
- W2103221503 hasLocation W21032215031 @default.
- W2103221503 hasLocation W21032215032 @default.
- W2103221503 hasOpenAccess W2103221503 @default.
- W2103221503 hasPrimaryLocation W21032215031 @default.
- W2103221503 hasRelatedWork W1963819880 @default.
- W2103221503 hasRelatedWork W2018781355 @default.
- W2103221503 hasRelatedWork W2107825767 @default.
- W2103221503 hasRelatedWork W2208853022 @default.
- W2103221503 hasRelatedWork W2550019792 @default.
- W2103221503 hasRelatedWork W2630893866 @default.