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- W2103229678 endingPage "61" @default.
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- W2103229678 abstract "The influence of adult stem cells on tumor growth is paradoxical. On one hand, angiogenic factors secreted by stem cells are known to be essential for tumor vascularization. On the other hand, stem cell-derived factors can reportedly induce tumor differentiation or direct death of tumor cells. Both the placenta and umbilical cord are rich sources of stem cells with immune modulatory and tissue-healing properties; however, the effects of placental components on cancer cells have not been fully defined. Here we demonstrate that extracts of placental lysates reduce the malignancy of a variety of human tumor cell lines in a species-unrestricted manner. Using a standard model of leukemia cell differentiation, we demonstrated that addition of placental extracts to tumor cells, or co-culture of tumor cells with the CD34(+) cells from umbilical cord blood, induced tumor cell differentiation. Inhibition of tumor growth and metastasis in vivo was also observed following administration of placental extracts. These data support the concept of non-toxic biological therapy of cancer using stem cell derivatives, possibly through the induction of tumor cell differentiation." @default.
- W2103229678 created "2016-06-24" @default.
- W2103229678 creator A5008902550 @default.
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- W2103229678 creator A5046722794 @default.
- W2103229678 creator A5047357867 @default.
- W2103229678 creator A5057237407 @default.
- W2103229678 date "2012-04-01" @default.
- W2103229678 modified "2023-09-23" @default.
- W2103229678 title "Reduction of tumorigenicity by placental extracts." @default.
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- W2103229678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22493344" @default.
- W2103229678 hasPublicationYear "2012" @default.
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