Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103230097> ?p ?o ?g. }
- W2103230097 endingPage "566" @default.
- W2103230097 startingPage "555" @default.
- W2103230097 abstract "Water permeation through rat aquaporin-4 (rAQP4), predominantly found in mammalian brain is regulated by phosphorylation of Ser-180. The present study has been carried out to understand the structural mechanism of regulation of water permeability across the channel. Molecular dynamics (MD) simulations have been carried out to investigate the structural changes caused due to phosphorylation of Ser-180 in the tetrameric assembly of rAQP4 along with predicted C-terminal region (255–323). The interactions involving opposite charges are observed between cytoplasmic loops and the C-terminal region during MD simulations. This results in movement of C-terminal region of rAQP4 towards the cytoplasmic mouth of water channel. Despite this movement, there was a gap between C-terminal region and cytoplasmic mouth of the channel through which water molecules were able to gain entry into the channel. The interactions between C-terminus and loop D of neighboring monomers in a tetrameric assembly appear to prevent the complete closure of cytoplasmic mouth of the water channel. Further, the rates of water permeation through phosphorylated and unphosphorylated rAQP4 have also been compared. The simulation studies showed a continuous movement of water in a single file across pore of unphosphorylated as well as phosphorylated rAQP4." @default.
- W2103230097 created "2016-06-24" @default.
- W2103230097 creator A5042175429 @default.
- W2103230097 creator A5059303953 @default.
- W2103230097 date "2013-05-07" @default.
- W2103230097 modified "2023-10-18" @default.
- W2103230097 title "Phosphorylation of Ser-180 of rat aquaporin-4 shows marginal affect on regulation of water permeability: molecular dynamics study" @default.
- W2103230097 cites W1512016817 @default.
- W2103230097 cites W1682819468 @default.
- W2103230097 cites W1963614683 @default.
- W2103230097 cites W1964254014 @default.
- W2103230097 cites W1976499671 @default.
- W2103230097 cites W1986191025 @default.
- W2103230097 cites W1988296977 @default.
- W2103230097 cites W1991285104 @default.
- W2103230097 cites W1992192767 @default.
- W2103230097 cites W1992518077 @default.
- W2103230097 cites W1993064989 @default.
- W2103230097 cites W1997282166 @default.
- W2103230097 cites W2005279807 @default.
- W2103230097 cites W2007003313 @default.
- W2103230097 cites W2009749225 @default.
- W2103230097 cites W2013904079 @default.
- W2103230097 cites W2014776147 @default.
- W2103230097 cites W2015415318 @default.
- W2103230097 cites W2027408247 @default.
- W2103230097 cites W2029360750 @default.
- W2103230097 cites W2029667189 @default.
- W2103230097 cites W2031275782 @default.
- W2103230097 cites W2035687084 @default.
- W2103230097 cites W2042000969 @default.
- W2103230097 cites W2065283382 @default.
- W2103230097 cites W2071486470 @default.
- W2103230097 cites W2078936885 @default.
- W2103230097 cites W2079280170 @default.
- W2103230097 cites W2084304818 @default.
- W2103230097 cites W2085820729 @default.
- W2103230097 cites W2087637788 @default.
- W2103230097 cites W2089708939 @default.
- W2103230097 cites W2092066224 @default.
- W2103230097 cites W2094566223 @default.
- W2103230097 cites W2102818658 @default.
- W2103230097 cites W2105546584 @default.
- W2103230097 cites W2106140689 @default.
- W2103230097 cites W2120679080 @default.
- W2103230097 cites W2142529984 @default.
- W2103230097 cites W2146878206 @default.
- W2103230097 cites W2150981663 @default.
- W2103230097 cites W2152265734 @default.
- W2103230097 cites W2155201844 @default.
- W2103230097 cites W2168053914 @default.
- W2103230097 cites W3206572385 @default.
- W2103230097 doi "https://doi.org/10.1080/07391102.2013.780981" @default.
- W2103230097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23651078" @default.
- W2103230097 hasPublicationYear "2013" @default.
- W2103230097 type Work @default.
- W2103230097 sameAs 2103230097 @default.
- W2103230097 citedByCount "16" @default.
- W2103230097 countsByYear W21032300972014 @default.
- W2103230097 countsByYear W21032300972015 @default.
- W2103230097 countsByYear W21032300972016 @default.
- W2103230097 countsByYear W21032300972017 @default.
- W2103230097 countsByYear W21032300972018 @default.
- W2103230097 countsByYear W21032300972020 @default.
- W2103230097 countsByYear W21032300972021 @default.
- W2103230097 countsByYear W21032300972022 @default.
- W2103230097 countsByYear W21032300972023 @default.
- W2103230097 crossrefType "journal-article" @default.
- W2103230097 hasAuthorship W2103230097A5042175429 @default.
- W2103230097 hasAuthorship W2103230097A5059303953 @default.
- W2103230097 hasConcept C11960822 @default.
- W2103230097 hasConcept C120882062 @default.
- W2103230097 hasConcept C12554922 @default.
- W2103230097 hasConcept C127413603 @default.
- W2103230097 hasConcept C147597530 @default.
- W2103230097 hasConcept C154280991 @default.
- W2103230097 hasConcept C15755913 @default.
- W2103230097 hasConcept C185592680 @default.
- W2103230097 hasConcept C190062978 @default.
- W2103230097 hasConcept C201289731 @default.
- W2103230097 hasConcept C2775845273 @default.
- W2103230097 hasConcept C2988574769 @default.
- W2103230097 hasConcept C41625074 @default.
- W2103230097 hasConcept C50670333 @default.
- W2103230097 hasConcept C515207424 @default.
- W2103230097 hasConcept C55493867 @default.
- W2103230097 hasConcept C57711820 @default.
- W2103230097 hasConcept C59593255 @default.
- W2103230097 hasConcept C78519656 @default.
- W2103230097 hasConcept C86803240 @default.
- W2103230097 hasConcept C87717796 @default.
- W2103230097 hasConcept C95444343 @default.
- W2103230097 hasConceptScore W2103230097C11960822 @default.
- W2103230097 hasConceptScore W2103230097C120882062 @default.
- W2103230097 hasConceptScore W2103230097C12554922 @default.
- W2103230097 hasConceptScore W2103230097C127413603 @default.
- W2103230097 hasConceptScore W2103230097C147597530 @default.
- W2103230097 hasConceptScore W2103230097C154280991 @default.