FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103231307> ?p ?o ?g. }

• W2103231307 endingPage "137" @default.
• W2103231307 startingPage "126" @default.
• W2103231307 abstract "Infection with DNA viruses commonly results in the association of viral genomes with a cellular subnuclear structure known as nuclear domain 10 (ND10). Recent studies demonstrated that individual ND10 components, like hDaxx or promyelocytic leukemia protein (PML), mediate an intrinsic immune response against human cytomegalovirus (HCMV) infection, strengthening the assumption that ND10 components are part of a cellular antiviral defense mechanism. In order to further define the role of hDaxx and PML for HCMV replication, we generated either primary human fibroblasts with a stable, individual knockdown of PML or hDaxx (PML-kd and hDaxx-kd, respectively) or cells exhibiting a double knockdown. Comparative analysis of HCMV replication in PML-kd or hDaxx-kd cells revealed that immediate-early (IE) gene expression increased to a similar extent, regardless of which ND10 constituent was depleted. Since a loss of PML, the defining component of ND10, results in a dispersal of the entire nuclear substructure, the increased replication efficacy of HCMV in PML-kd cells could be a consequence of the dissociation of the repressor protein hDaxx from its optimal subnuclear localization. However, experiments using three different recombinant HCMVs revealed a differential growth complementation in PML-kd versus hDaxx-kd cells, strongly arguing for an independent involvement in suppressing HCMV replication. Furthermore, infection experiments using double-knockdown cells devoid of both PML and hDaxx illustrated an additional enhancement in the replication efficacy of HCMV compared to the single-knockdown cells. Taken together, our data indicate that both proteins, PML and hDaxx, mediate an intrinsic immune response against HCMV infection by contributing independently to the silencing of HCMV IE gene expression." @default.
• W2103231307 created "2016-06-24" @default.
• W2103231307 creator A5009244492 @default.
• W2103231307 creator A5031660301 @default.
• W2103231307 creator A5035412838 @default.
• W2103231307 creator A5089627589 @default.
• W2103231307 date "2008-01-01" @default.
• W2103231307 modified "2023-09-23" @default.
• W2103231307 title "Nuclear Domain 10 Components Promyelocytic Leukemia Protein and hDaxx Independently Contribute to an Intrinsic Antiviral Defense against Human Cytomegalovirus Infection" @default.
• W2103231307 cites W1517778647 @default.
• W2103231307 cites W1524972657 @default.
• W2103231307 cites W1545721254 @default.
• W2103231307 cites W1586627611 @default.
• W2103231307 cites W1898584802 @default.
• W2103231307 cites W1931686165 @default.
• W2103231307 cites W1965048581 @default.
• W2103231307 cites W1968537310 @default.
• W2103231307 cites W1968697793 @default.
• W2103231307 cites W1969098376 @default.
• W2103231307 cites W1978048533 @default.
• W2103231307 cites W1978728124 @default.
• W2103231307 cites W1987560539 @default.
• W2103231307 cites W1988154113 @default.
• W2103231307 cites W1988960910 @default.
• W2103231307 cites W1989142628 @default.
• W2103231307 cites W2023930134 @default.
• W2103231307 cites W2052876635 @default.
• W2103231307 cites W2084970371 @default.
• W2103231307 cites W2090672652 @default.
• W2103231307 cites W2091115188 @default.
• W2103231307 cites W2097882890 @default.
• W2103231307 cites W2102621085 @default.
• W2103231307 cites W2106581706 @default.
• W2103231307 cites W2109032735 @default.
• W2103231307 cites W2110429239 @default.
• W2103231307 cites W2115445757 @default.
• W2103231307 cites W2116137883 @default.
• W2103231307 cites W2117568376 @default.
• W2103231307 cites W2119771480 @default.
• W2103231307 cites W2120015511 @default.
• W2103231307 cites W2120765611 @default.
• W2103231307 cites W2121059558 @default.
• W2103231307 cites W2122308980 @default.
• W2103231307 cites W2125000624 @default.
• W2103231307 cites W2126689485 @default.
• W2103231307 cites W2127707170 @default.
• W2103231307 cites W2129129058 @default.
• W2103231307 cites W2129737437 @default.
• W2103231307 cites W2131468538 @default.
• W2103231307 cites W2132759801 @default.
• W2103231307 cites W2135463922 @default.
• W2103231307 cites W2139210334 @default.
• W2103231307 cites W2144284827 @default.
• W2103231307 cites W2145469304 @default.
• W2103231307 cites W2153671958 @default.
• W2103231307 cites W2153729880 @default.
• W2103231307 cites W2160623917 @default.
• W2103231307 cites W2187131173 @default.
• W2103231307 cites W2261355130 @default.
• W2103231307 cites W2335418691 @default.
• W2103231307 doi "https://doi.org/10.1128/jvi.01685-07" @default.
• W2103231307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2224380" @default.
• W2103231307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17942542" @default.
• W2103231307 hasPublicationYear "2008" @default.
• W2103231307 type Work @default.
• W2103231307 sameAs 2103231307 @default.
• W2103231307 citedByCount "113" @default.
• W2103231307 countsByYear W21032313072012 @default.
• W2103231307 countsByYear W21032313072013 @default.
• W2103231307 countsByYear W21032313072014 @default.
• W2103231307 countsByYear W21032313072015 @default.
• W2103231307 countsByYear W21032313072016 @default.
• W2103231307 countsByYear W21032313072017 @default.
• W2103231307 countsByYear W21032313072018 @default.
• W2103231307 countsByYear W21032313072019 @default.
• W2103231307 countsByYear W21032313072020 @default.
• W2103231307 countsByYear W21032313072021 @default.
• W2103231307 countsByYear W21032313072022 @default.
• W2103231307 crossrefType "journal-article" @default.
• W2103231307 hasAuthorship W2103231307A5009244492 @default.
• W2103231307 hasAuthorship W2103231307A5031660301 @default.
• W2103231307 hasAuthorship W2103231307A5035412838 @default.
• W2103231307 hasAuthorship W2103231307A5089627589 @default.
• W2103231307 hasBestOaLocation W21032313071 @default.
• W2103231307 hasConcept C104317684 @default.
• W2103231307 hasConcept C111441629 @default.
• W2103231307 hasConcept C140704245 @default.
• W2103231307 hasConcept C159047783 @default.
• W2103231307 hasConcept C173396325 @default.
• W2103231307 hasConcept C2522874641 @default.
• W2103231307 hasConcept C2779820661 @default.
• W2103231307 hasConcept C29512474 @default.
• W2103231307 hasConcept C54355233 @default.
• W2103231307 hasConcept C71829478 @default.
• W2103231307 hasConcept C81885089 @default.
• W2103231307 hasConcept C86339819 @default.
• W2103231307 hasConcept C86803240 @default.
• W2103231307 hasConcept C89380225 @default.

• next