FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103231362> ?p ?o ?g. }

• W2103231362 endingPage "3238" @default.
• W2103231362 startingPage "3229" @default.
• W2103231362 abstract "Because regulatory T-cell (Treg) development can be induced by the same agonist self-antigens that induce negative selection, perturbation of apoptosis will affect both negative selection and Treg development. But how the processes of thymocyte deletion versus Treg differentiation bifurcate and their relative importance for tolerance have not been studied in spontaneous organ-specific autoimmune disease. We addressed these questions by removing a critical mediator of thymocyte deletion, BIM, in the NOD mouse model of autoimmune diabetes. Despite substantial defects in the deletion of autoreactive thymocytes, BIM-deficient NOD (NODBim(-/-)) mice developed less insulitis and were protected from diabetes. BIM deficiency did not impair effector T-cell function; however, NODBim(-/-) mice had increased numbers of Tregs, including those specific for proinsulin, in the thymus and peripheral lymphoid tissues. Increased levels of Nur77, CD5, GITR, and phosphorylated IκB-α in thymocytes from NODBim(-/-) mice suggest that autoreactive cells receiving strong T-cell receptor signals that would normally delete them escape apoptosis and are diverted into the Treg pathway. Paradoxically, in the NOD model, reduced thymic deletion ameliorates autoimmune diabetes by increasing Tregs. Thus, modulating apoptosis may be one of the ways to increase antigen-specific Tregs and prevent autoimmune disease." @default.
• W2103231362 created "2016-06-24" @default.
• W2103231362 creator A5011263962 @default.
• W2103231362 creator A5013077508 @default.
• W2103231362 creator A5024147668 @default.
• W2103231362 creator A5028970535 @default.
• W2103231362 creator A5034286039 @default.
• W2103231362 creator A5039875937 @default.
• W2103231362 creator A5040126252 @default.
• W2103231362 creator A5041892653 @default.
• W2103231362 creator A5045794736 @default.
• W2103231362 creator A5046532595 @default.
• W2103231362 creator A5048730233 @default.
• W2103231362 creator A5062810490 @default.
• W2103231362 creator A5078006107 @default.
• W2103231362 creator A5080249486 @default.
• W2103231362 creator A5089157500 @default.
• W2103231362 creator A5090978429 @default.
• W2103231362 date "2015-05-06" @default.
• W2103231362 modified "2023-10-16" @default.
• W2103231362 title "BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells" @default.
• W2103231362 cites W1522935969 @default.
• W2103231362 cites W1530782041 @default.
• W2103231362 cites W1555988808 @default.
• W2103231362 cites W1565175113 @default.
• W2103231362 cites W1606653742 @default.
• W2103231362 cites W1967579996 @default.
• W2103231362 cites W1976046290 @default.
• W2103231362 cites W1980050753 @default.
• W2103231362 cites W1999625746 @default.
• W2103231362 cites W1999760992 @default.
• W2103231362 cites W2003257616 @default.
• W2103231362 cites W2012632639 @default.
• W2103231362 cites W2014634158 @default.
• W2103231362 cites W2015680329 @default.
• W2103231362 cites W2030243679 @default.
• W2103231362 cites W2047366270 @default.
• W2103231362 cites W2048659881 @default.
• W2103231362 cites W2049740824 @default.
• W2103231362 cites W2076176535 @default.
• W2103231362 cites W2079650395 @default.
• W2103231362 cites W2081646445 @default.
• W2103231362 cites W2082137006 @default.
• W2103231362 cites W2085918020 @default.
• W2103231362 cites W2086595653 @default.
• W2103231362 cites W2091128918 @default.
• W2103231362 cites W2093302170 @default.
• W2103231362 cites W2097414777 @default.
• W2103231362 cites W2104919278 @default.
• W2103231362 cites W2107644576 @default.
• W2103231362 cites W2111329034 @default.
• W2103231362 cites W2113799022 @default.
• W2103231362 cites W2114569569 @default.
• W2103231362 cites W2117644665 @default.
• W2103231362 cites W2122379385 @default.
• W2103231362 cites W2122726748 @default.
• W2103231362 cites W2125679681 @default.
• W2103231362 cites W2126274788 @default.
• W2103231362 cites W2127605217 @default.
• W2103231362 cites W2128882575 @default.
• W2103231362 cites W2134842718 @default.
• W2103231362 cites W2134855858 @default.
• W2103231362 cites W2135396866 @default.
• W2103231362 cites W2155521069 @default.
• W2103231362 cites W2157740207 @default.
• W2103231362 cites W2166228664 @default.
• W2103231362 cites W2166916498 @default.
• W2103231362 cites W2169645077 @default.
• W2103231362 doi "https://doi.org/10.2337/db14-1851" @default.
• W2103231362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25948683" @default.
• W2103231362 hasPublicationYear "2015" @default.
• W2103231362 type Work @default.
• W2103231362 sameAs 2103231362 @default.
• W2103231362 citedByCount "15" @default.
• W2103231362 countsByYear W21032313622015 @default.
• W2103231362 countsByYear W21032313622016 @default.
• W2103231362 countsByYear W21032313622017 @default.
• W2103231362 countsByYear W21032313622018 @default.
• W2103231362 countsByYear W21032313622019 @default.
• W2103231362 countsByYear W21032313622021 @default.
• W2103231362 countsByYear W21032313622023 @default.
• W2103231362 crossrefType "journal-article" @default.
• W2103231362 hasAuthorship W2103231362A5011263962 @default.
• W2103231362 hasAuthorship W2103231362A5013077508 @default.
• W2103231362 hasAuthorship W2103231362A5024147668 @default.
• W2103231362 hasAuthorship W2103231362A5028970535 @default.
• W2103231362 hasAuthorship W2103231362A5034286039 @default.
• W2103231362 hasAuthorship W2103231362A5039875937 @default.
• W2103231362 hasAuthorship W2103231362A5040126252 @default.
• W2103231362 hasAuthorship W2103231362A5041892653 @default.
• W2103231362 hasAuthorship W2103231362A5045794736 @default.
• W2103231362 hasAuthorship W2103231362A5046532595 @default.
• W2103231362 hasAuthorship W2103231362A5048730233 @default.
• W2103231362 hasAuthorship W2103231362A5062810490 @default.
• W2103231362 hasAuthorship W2103231362A5078006107 @default.
• W2103231362 hasAuthorship W2103231362A5080249486 @default.
• W2103231362 hasAuthorship W2103231362A5089157500 @default.
• W2103231362 hasAuthorship W2103231362A5090978429 @default.

• next