FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103232294> ?p ?o ?g. }

• W2103232294 endingPage "4826" @default.
• W2103232294 startingPage "4821" @default.
• W2103232294 abstract "We have recently engineered an in vivo endothelial cell-specific retroviral gene transfer system and found that a single Kaposi's sarcoma (KS)-associated herpesvirus/human herpesvirus 8 gene encoding a G protein-coupled receptor (vGPCR), is sufficient to induce KS-like tumors in mice. By using this system, we show here that the Akt signaling pathway plays a central role in vGPCR oncogenesis. Indeed, a constitutively active Akt was sufficient to induce benign hemangiomas in mice, whereas heterozyogosity for PTEN (the phosphatase and tension homologue deleted on chromosome 10), modestly enhancing basal Akt activity, dramatically enhanced vGPCR sarcomagenesis. Examination of KS biopsies from AIDS patients revealed active Akt as a prominent feature, supportive of a role for Akt in human Kaposi's sarcomagenesis. By using a vGPCR agonist-dependent mutant, we further establish constitutive activity as a requirement for vGPCR sarcomagenesis, validating targeted inhibition of key vGPCR signaling pathways as an approach for preventing its oncogenic potential. These observations prompted us to explore the efficacy of inhibiting Akt activation as a molecular approach to KS treatment. Pharmacological inhibition of the Akt pathway with the chemotherapeutic agent 7-hydroxystaurosporine prevented proliferation of vGPCR-expressing endothelial cells in vitro and inhibited their tumorigenic potential in vivo. Both were associated with a decrease in Akt activity. These results identify Akt as an essential player in vGPCR sarcomagenesis and demonstrate the therapeutic potential of drugs targeting this pathway in the treatment of KS." @default.
• W2103232294 created "2016-06-24" @default.
• W2103232294 creator A5006477586 @default.
• W2103232294 creator A5030668464 @default.
• W2103232294 creator A5038753309 @default.
• W2103232294 creator A5061026061 @default.
• W2103232294 creator A5064708667 @default.
• W2103232294 creator A5064842058 @default.
• W2103232294 creator A5082507805 @default.
• W2103232294 creator A5082745210 @default.
• W2103232294 date "2004-03-26" @default.
• W2103232294 modified "2023-09-23" @default.
• W2103232294 title "Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor" @default.
• W2103232294 cites W1483350500 @default.
• W2103232294 cites W1523189699 @default.
• W2103232294 cites W1538814462 @default.
• W2103232294 cites W1539096485 @default.
• W2103232294 cites W1548270485 @default.
• W2103232294 cites W1587318259 @default.
• W2103232294 cites W1604210388 @default.
• W2103232294 cites W1673837423 @default.
• W2103232294 cites W1712224666 @default.
• W2103232294 cites W1766452247 @default.
• W2103232294 cites W1896635905 @default.
• W2103232294 cites W1969563526 @default.
• W2103232294 cites W1970200563 @default.
• W2103232294 cites W1982047106 @default.
• W2103232294 cites W1984418041 @default.
• W2103232294 cites W1988743962 @default.
• W2103232294 cites W1990386824 @default.
• W2103232294 cites W1998291423 @default.
• W2103232294 cites W2003291578 @default.
• W2103232294 cites W2004427963 @default.
• W2103232294 cites W2012211657 @default.
• W2103232294 cites W2021522625 @default.
• W2103232294 cites W2032438721 @default.
• W2103232294 cites W2041795984 @default.
• W2103232294 cites W2043806397 @default.
• W2103232294 cites W2052750950 @default.
• W2103232294 cites W2064505617 @default.
• W2103232294 cites W2070204121 @default.
• W2103232294 cites W2071622027 @default.
• W2103232294 cites W2075556833 @default.
• W2103232294 cites W2077416276 @default.
• W2103232294 cites W2081237630 @default.
• W2103232294 cites W2084391519 @default.
• W2103232294 cites W2087431503 @default.
• W2103232294 cites W2094957750 @default.
• W2103232294 cites W2099618955 @default.
• W2103232294 cites W2108408806 @default.
• W2103232294 cites W2111263744 @default.
• W2103232294 cites W2121100324 @default.
• W2103232294 cites W2123045210 @default.
• W2103232294 cites W2124670069 @default.
• W2103232294 cites W2129133722 @default.
• W2103232294 cites W2136357286 @default.
• W2103232294 cites W2146854995 @default.
• W2103232294 cites W2149453948 @default.
• W2103232294 cites W2152988906 @default.
• W2103232294 cites W2161810908 @default.
• W2103232294 cites W2162517036 @default.
• W2103232294 cites W2290209699 @default.
• W2103232294 cites W2388163742 @default.
• W2103232294 cites W2399708443 @default.
• W2103232294 cites W2951294297 @default.
• W2103232294 cites W4233391937 @default.
• W2103232294 cites W4247904703 @default.
• W2103232294 doi "https://doi.org/10.1073/pnas.0400835101" @default.
• W2103232294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387332" @default.
• W2103232294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15047889" @default.
• W2103232294 hasPublicationYear "2004" @default.
• W2103232294 type Work @default.
• W2103232294 sameAs 2103232294 @default.
• W2103232294 citedByCount "147" @default.
• W2103232294 countsByYear W21032322942012 @default.
• W2103232294 countsByYear W21032322942013 @default.
• W2103232294 countsByYear W21032322942014 @default.
• W2103232294 countsByYear W21032322942015 @default.
• W2103232294 countsByYear W21032322942016 @default.
• W2103232294 countsByYear W21032322942017 @default.
• W2103232294 countsByYear W21032322942018 @default.
• W2103232294 countsByYear W21032322942019 @default.
• W2103232294 countsByYear W21032322942020 @default.
• W2103232294 countsByYear W21032322942021 @default.
• W2103232294 countsByYear W21032322942022 @default.
• W2103232294 countsByYear W21032322942023 @default.
• W2103232294 crossrefType "journal-article" @default.
• W2103232294 hasAuthorship W2103232294A5006477586 @default.
• W2103232294 hasAuthorship W2103232294A5030668464 @default.
• W2103232294 hasAuthorship W2103232294A5038753309 @default.
• W2103232294 hasAuthorship W2103232294A5061026061 @default.
• W2103232294 hasAuthorship W2103232294A5064708667 @default.
• W2103232294 hasAuthorship W2103232294A5064842058 @default.
• W2103232294 hasAuthorship W2103232294A5082507805 @default.
• W2103232294 hasAuthorship W2103232294A5082745210 @default.
• W2103232294 hasBestOaLocation W21032322941 @default.
• W2103232294 hasConcept C135285700 @default.
• W2103232294 hasConcept C2777609662 @default.

• next