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- W2103234337 endingPage "237" @default.
- W2103234337 startingPage "229" @default.
- W2103234337 abstract "Comparative analyses of fungal genomes and molecular research on genes associated with fungal viability and virulence has led to the identification of many putative targets for novel antifungal agents. So far the rational approach to antifungal discovery, in which compounds are optimized against an individual target then progressed to efficacy against intact fungi and ultimately to infected humans has delivered no new agents. However, the approach continues to hold promise for the future. This review critically assesses the molecular target-based approach to antifungal discovery, outlines problems and pitfalls inherent in the genomics and target discovery strategies and describes the status of heavily investigated examples of target-based research. Los análisis comparativos de los genomas fúngicos y la investigación molecular en genes asociados con la viabilidad fúngica y la virulencia han conducido a la identificación de muchas dianas potenciales para nuevos antifúngicos. Por el momento, la vía racional para el descubrimiento de antifúngicos, en la que los compuestos son optimizados contra una diana individual, después mejorada su eficacia contra hongos intactos y, finalmente, frente a pacientes infectados, no ha proporcionado nuevos agentes. Sin embargo, esta vía continúa manteniendo promesas para el futuro. Este artículo revisa críticamente la vía basada en la diana molecular para el descubrimiento de antifúngicos, señala los problemas y trampas inherentes a las estrategias genómicas y de descubrimiento de dianas, y describe la situación de ejemplos profundamente estudiados en investigación basada en dianas moleculares." @default.
- W2103234337 created "2016-06-24" @default.
- W2103234337 creator A5030174171 @default.
- W2103234337 date "2005-12-01" @default.
- W2103234337 modified "2023-10-18" @default.
- W2103234337 title "Genomics, molecular targets and the discovery of antifungal drugs" @default.
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