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• W2103235451 startingPage "43" @default.
• W2103235451 abstract "Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, inhibited RasV12-induced senescence. Cells that senesced in response to ca-STAT5A or RasV12 accumulated DNA damage foci and activated ATM, ATR, Chk1, and Chk2, indicating that aberrant oncogene activation induces a DNA damage signaling response. Intriguingly, bypassing oncogene-induced senescence by inactivation of p53 and Rb did not eliminate the accumulation of oncogene-induced DNA damage foci (ODDI), suggesting a mechanism that may limit transformation in immortalized cells." @default.
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• W2103235451 creator A5084718558 @default.
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• W2103235451 date "2007-01-01" @default.
• W2103235451 modified "2023-10-15" @default.
• W2103235451 title "The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence" @default.
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• W2103235451 doi "https://doi.org/10.1101/gad.1487307" @default.
• W2103235451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1759898" @default.
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