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- W2103239365 endingPage "833" @default.
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- W2103239365 abstract "Abstract mRNA stability is increasingly recognized as being essential for controlling the expression of a wide variety of transcripts during neuronal development and synaptic plasticity. In this context, the role of AU‐rich elements (ARE) contained within the 3′ untranslated region (UTR) of transcripts has now emerged as key because of their high incidence in a large number of cellular mRNAs. This important regulatory element is known to significantly modulate the longevity of mRNAs by interacting with available stabilizing or destabilizing RNA‐binding proteins (RBP). Thus, in parallel with the emergence of ARE, RBP are also gaining recognition for their pivotal role in regulating expression of a variety of mRNAs. In the nervous system, the member of the Hu family of ARE‐binding proteins known as HuD, has recently been implicated in multiple aspects of neuronal function including the commitment and differentiation of neuronal precursors as well as synaptic remodeling in mature neurons. Through its ability to interact with ARE and stabilize multiple transcripts, HuD has now emerged as an important regulator of mRNA expression in neurons. The present review is designed to provide a comprehensive and updated view of HuD as an RBP in the nervous system. Additionally, we highlight the role of HuD in multiple aspects of a neuron's life from early differentiation to changes in mature neurons during learning paradigms and in response to injury and regeneration. Finally, we describe the current state of knowledge concerning the molecular and cellular events regulating the expression and activity of HuD in neurons. BioEssays 28: 822–833, 2006. © 2006 Wiley Periodicals, Inc." @default.
- W2103239365 created "2016-06-24" @default.
- W2103239365 creator A5026184632 @default.
- W2103239365 creator A5028486268 @default.
- W2103239365 creator A5073725247 @default.
- W2103239365 date "2006-08-01" @default.
- W2103239365 modified "2023-10-04" @default.
- W2103239365 title "The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity" @default.
- W2103239365 cites W147388322 @default.
- W2103239365 cites W1535983677 @default.
- W2103239365 cites W1562398969 @default.
- W2103239365 cites W1588809921 @default.
- W2103239365 cites W1605365699 @default.
- W2103239365 cites W1642485298 @default.
- W2103239365 cites W1826852120 @default.
- W2103239365 cites W1846410774 @default.
- W2103239365 cites W1864265177 @default.
- W2103239365 cites W1895804627 @default.
- W2103239365 cites W1964457265 @default.
- W2103239365 cites W1967554461 @default.
- W2103239365 cites W1968242863 @default.
- W2103239365 cites W19715912 @default.
- W2103239365 cites W1978958505 @default.
- W2103239365 cites W1980060880 @default.
- W2103239365 cites W1980084095 @default.
- W2103239365 cites W1981992333 @default.
- W2103239365 cites W1982369409 @default.
- W2103239365 cites W1986804263 @default.
- W2103239365 cites W1988425964 @default.
- W2103239365 cites W1988520219 @default.
- W2103239365 cites W1989463841 @default.
- W2103239365 cites W1991110166 @default.
- W2103239365 cites W1991135240 @default.
- W2103239365 cites W1991423906 @default.
- W2103239365 cites W1992240096 @default.
- W2103239365 cites W1996789245 @default.
- W2103239365 cites W1998938482 @default.
- W2103239365 cites W2001504986 @default.
- W2103239365 cites W2001889965 @default.
- W2103239365 cites W2002282713 @default.
- W2103239365 cites W2008416692 @default.
- W2103239365 cites W2010516854 @default.
- W2103239365 cites W2011326170 @default.
- W2103239365 cites W2011850350 @default.
- W2103239365 cites W2016196890 @default.
- W2103239365 cites W2018305915 @default.
- W2103239365 cites W2019178696 @default.
- W2103239365 cites W2019563964 @default.
- W2103239365 cites W2020359867 @default.
- W2103239365 cites W2020809429 @default.
- W2103239365 cites W2025728827 @default.
- W2103239365 cites W2028694253 @default.
- W2103239365 cites W2029062117 @default.
- W2103239365 cites W2029706883 @default.
- W2103239365 cites W2031247595 @default.
- W2103239365 cites W2033305072 @default.
- W2103239365 cites W2035151000 @default.
- W2103239365 cites W2035261316 @default.
- W2103239365 cites W2035618537 @default.
- W2103239365 cites W2035869111 @default.
- W2103239365 cites W2039298735 @default.
- W2103239365 cites W2040890514 @default.
- W2103239365 cites W2043182417 @default.
- W2103239365 cites W2043549713 @default.
- W2103239365 cites W2044273755 @default.
- W2103239365 cites W2044429312 @default.
- W2103239365 cites W2045309201 @default.
- W2103239365 cites W2047749236 @default.
- W2103239365 cites W2048651813 @default.
- W2103239365 cites W2052483187 @default.
- W2103239365 cites W2052496682 @default.
- W2103239365 cites W2052560889 @default.
- W2103239365 cites W2052632013 @default.
- W2103239365 cites W2052969704 @default.
- W2103239365 cites W2055930249 @default.
- W2103239365 cites W2056200986 @default.
- W2103239365 cites W2060588507 @default.
- W2103239365 cites W2061217906 @default.
- W2103239365 cites W2070365794 @default.
- W2103239365 cites W2070542531 @default.
- W2103239365 cites W2073654740 @default.
- W2103239365 cites W2076510291 @default.
- W2103239365 cites W2076849957 @default.
- W2103239365 cites W2081228528 @default.
- W2103239365 cites W2082551528 @default.
- W2103239365 cites W2085709349 @default.
- W2103239365 cites W2087093477 @default.
- W2103239365 cites W2087401509 @default.
- W2103239365 cites W2091549056 @default.
- W2103239365 cites W2093625208 @default.
- W2103239365 cites W2097617128 @default.
- W2103239365 cites W2099791270 @default.
- W2103239365 cites W2100649307 @default.
- W2103239365 cites W2102606027 @default.
- W2103239365 cites W2102812687 @default.
- W2103239365 cites W2102914307 @default.
- W2103239365 cites W2104950011 @default.
- W2103239365 cites W2106825949 @default.