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• W2103239623 abstract "Early identification of Mild Cognitive Impairment (MCI) that progresses to Alzheimer's would reduce the speed of disease progression and delay placements in nursing homes. Unfortunately, MCI often goes undetected. The CANS-MCI is a computerized screening measure designed for usability in clinicians’ offices, which provides screening information about the need for full diagnostic evaluations for dementia. To determine the effectiveness of CANS-MCI scoring algorithms to detect MCI with respect to the criterion standard of longitudinal neuropsychological evaluations. 290 elderly community-dwelling volunteers enrolled in a 3-year longitudinal NIA-funded study. Logistic regression and ROC curve analyses were run on a sub-sample of study participants who received baseline and 1-year follow-up full neuropsychological evaluations (N= 74). Follow-up analyses are presented here. Based on the criterion standard categorization (normal vs. impaired) on 3 factors (Memory, Executive Function, Fluency) for 1-year follow-up scores, we generated scoring algorithms using logistic regression that best fit the data. We created two separate algorithms based on level of education (<= 12 yrs. and 13+ yrs.). These correctly classified 85% of participants with a high school degree or less (Chi-square= 11.74) and80% of those with at least some college (Chi-square= 31.41). ROC curve analyses on the two educational levels revealed that cut-points lead to sensitivities/specificities of .93/.83 (<=12 yrs) and .77/.83 (13+ yrs). Areas under the curve were high (.917 for <= 12 yrs education and .888 for 13+ yrs). These findings indicate that the CANS-MCI is an effective screen for the need for full neuropsychological evaluations. However, a larger sample is needed to produce a more robust algorithm for individuals with low levels of education. Multiple screenings over time are recommended for highest predictive validity." @default.
• W2103239623 created "2016-06-24" @default.
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• W2103239623 date "2005-07-01" @default.
• W2103239623 modified "2023-09-27" @default.
• W2103239623 title "[P-053]: One year follow-up analyses of scoring algorithms for a Mild Cognitive Impairment screen: The CANS-MCI Study" @default.
• W2103239623 doi "https://doi.org/10.1016/j.jalz.2005.06.115" @default.
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