FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103241622> ?p ?o ?g. }

• W2103241622 endingPage "603" @default.
• W2103241622 startingPage "591" @default.
• W2103241622 abstract "Intra-neuronal metabolism of dopamine (DA) begins with production of 3,4-dihydroxyphenylacetaldehyde (DOPAL),which is toxic. According to the 'catecholaldehyde hypothesis', DOPAL destroys nigrostriatal DA terminals and contributes to the profound putamen DA deficiency that characterizes Parkinson’s disease (PD). We tested the feasibility of using post-mortem patterns of putamen tissue catechols to examine contributions of altered activities of the type 2 vesicular monoamine transporter (VMAT2) and aldehyde dehydrogenase(ALDH) to the increased DOPAL levels found in PD. Theoretically, the DA : DOPA concentration ratio indicates vesicular uptake, and the 3,4-dihydroxyphenylacetic acid: DOPAL ratio indicates ALDH activity. We validated these indices in transgenic mice with very low vesicular uptake VMAT2-Lo) or with knockouts of the genes encoding ALDH1A1 and ALDH2 (ALDH1A1,2 KO), applied these indices in PD putamen, and estimated the percent decreases in vesicular uptake and ALDH activity in PD. VMAT2-Lo mice had markedly decreased DA:DOPA (50 vs. 1377, p < 0.0001),and ALDH1A1,2 KO mice had decreased 3,4-dihydroxyphenylacetic acid:DOPAL (1.0 vs. 11.2, p < 0.0001). In PD putamen, vesicular uptake was estimated to be decreased by 89% and ALDH activity by 70%. Elevated DOPAL levels in PD putamen reflect a combination of decreased vesicular uptake of cytosolic DA and decreased DOPAL detoxification by ALDH." @default.
• W2103241622 created "2016-06-24" @default.
• W2103241622 creator A5012621435 @default.
• W2103241622 creator A5020316181 @default.
• W2103241622 creator A5031586469 @default.
• W2103241622 creator A5041333857 @default.
• W2103241622 creator A5042803304 @default.
• W2103241622 creator A5042995179 @default.
• W2103241622 creator A5050003203 @default.
• W2103241622 creator A5057348787 @default.
• W2103241622 creator A5084723460 @default.
• W2103241622 date "2013-07-22" @default.
• W2103241622 modified "2023-10-16" @default.
• W2103241622 title "Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease" @default.
• W2103241622 cites W1547461458 @default.
• W2103241622 cites W175006040 @default.
• W2103241622 cites W1964189568 @default.
• W2103241622 cites W1964642241 @default.
• W2103241622 cites W1965138638 @default.
• W2103241622 cites W1970128454 @default.
• W2103241622 cites W1973033940 @default.
• W2103241622 cites W1975957833 @default.
• W2103241622 cites W1993675056 @default.
• W2103241622 cites W1994731568 @default.
• W2103241622 cites W1995335941 @default.
• W2103241622 cites W2006622455 @default.
• W2103241622 cites W2007635795 @default.
• W2103241622 cites W2009371512 @default.
• W2103241622 cites W2010113211 @default.
• W2103241622 cites W2010947186 @default.
• W2103241622 cites W2013819259 @default.
• W2103241622 cites W2016756266 @default.
• W2103241622 cites W2025421048 @default.
• W2103241622 cites W2027822127 @default.
• W2103241622 cites W2037280127 @default.
• W2103241622 cites W2041210568 @default.
• W2103241622 cites W2042226288 @default.
• W2103241622 cites W2047565527 @default.
• W2103241622 cites W2065948194 @default.
• W2103241622 cites W2067766554 @default.
• W2103241622 cites W2068509668 @default.
• W2103241622 cites W2071627769 @default.
• W2103241622 cites W2078245222 @default.
• W2103241622 cites W2082168061 @default.
• W2103241622 cites W2085669111 @default.
• W2103241622 cites W2085674390 @default.
• W2103241622 cites W2091280342 @default.
• W2103241622 cites W2091561143 @default.
• W2103241622 cites W2103866720 @default.
• W2103241622 cites W2109379634 @default.
• W2103241622 cites W2112648950 @default.
• W2103241622 cites W2118389697 @default.
• W2103241622 cites W2122317835 @default.
• W2103241622 cites W2122742102 @default.
• W2103241622 cites W2123431154 @default.
• W2103241622 cites W2127866446 @default.
• W2103241622 cites W2141410612 @default.
• W2103241622 cites W2144217997 @default.
• W2103241622 cites W2149510661 @default.
• W2103241622 cites W2150656456 @default.
• W2103241622 cites W2161756416 @default.
• W2103241622 cites W2164853857 @default.
• W2103241622 cites W2167764108 @default.
• W2103241622 doi "https://doi.org/10.1111/jnc.12345" @default.
• W2103241622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096629" @default.
• W2103241622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23786406" @default.
• W2103241622 hasPublicationYear "2013" @default.
• W2103241622 type Work @default.
• W2103241622 sameAs 2103241622 @default.
• W2103241622 citedByCount "162" @default.
• W2103241622 countsByYear W21032416222013 @default.
• W2103241622 countsByYear W21032416222014 @default.
• W2103241622 countsByYear W21032416222015 @default.
• W2103241622 countsByYear W21032416222016 @default.
• W2103241622 countsByYear W21032416222017 @default.
• W2103241622 countsByYear W21032416222018 @default.
• W2103241622 countsByYear W21032416222019 @default.
• W2103241622 countsByYear W21032416222020 @default.
• W2103241622 countsByYear W21032416222021 @default.
• W2103241622 countsByYear W21032416222022 @default.
• W2103241622 countsByYear W21032416222023 @default.
• W2103241622 crossrefType "journal-article" @default.
• W2103241622 hasAuthorship W2103241622A5012621435 @default.
• W2103241622 hasAuthorship W2103241622A5020316181 @default.
• W2103241622 hasAuthorship W2103241622A5031586469 @default.
• W2103241622 hasAuthorship W2103241622A5041333857 @default.
• W2103241622 hasAuthorship W2103241622A5042803304 @default.
• W2103241622 hasAuthorship W2103241622A5042995179 @default.
• W2103241622 hasAuthorship W2103241622A5050003203 @default.
• W2103241622 hasAuthorship W2103241622A5057348787 @default.
• W2103241622 hasAuthorship W2103241622A5084723460 @default.
• W2103241622 hasBestOaLocation W21032416221 @default.
• W2103241622 hasConcept C126322002 @default.
• W2103241622 hasConcept C134018914 @default.
• W2103241622 hasConcept C137183658 @default.
• W2103241622 hasConcept C170493617 @default.
• W2103241622 hasConcept C181199279 @default.
• W2103241622 hasConcept C185592680 @default.

• next