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• W2103241672 abstract "The interaction of myelin basic protein (MBP) with large unilamellar vesicles, composed of phosphatidylserine (PtdSer), phosphatidylserine/phosphatidylcholine (PtdSer/Ole2GroPCho) and phosphatidylcholine/cholesterol (Ole2GroPCho/cholesterol) was examined. Binding of MBP to the bilayers as well as the kinetics of this process were determined by a resonance energy transfer procedure. The ability of the protein to aggregate the vesicles subsequently was monitored continuously by absorbance measurements. The interaction was further characterized by determining the ability of MBP to induce membrane perturbations, as reflected by release of aqueous vesicle contents, and lipid mixing. The results demonstrate that Ole2GroPCho inhibits, while PtdSer and cholesterol strongly facilitate MBP-induced membrane aggregation. Furthermore, binding of MBP to vesicles and the subsequent aggregation event are separate processes, i.e. the extent of binding does not necessarily reflect the aggregation susceptibility. Overall, aggregation appears to be the rate-limiting step. Interaction of MBP with PtdSer bilayers results in a limited degree of lipid mixing, which is accompanied by extensive release of vesicle contents. For all other compositions, no lipid mixing occurs, while cholesterol effectively prevents release of vesicle contents. pH-dependent experiments indicate distinct mechanisms to be operative in MBP-induced aggregation of PtdSer and Ole2GroPCho/cholesterol bilayers. At neutral pH, protein-protein interactions appear relevant, while at acidic pH intervesicular bridges, established by monomers that may cause aggregation of PtdSer vesicles, but not of Ole2GroPCho/cholesterol vesicles. The observation that divalent cations reverse MBP-induced vesicle aggregation may have physiological relevance." @default.
• W2103241672 created "2016-06-24" @default.
• W2103241672 creator A5024003167 @default.
• W2103241672 creator A5067826648 @default.
• W2103241672 date "1993-02-01" @default.
• W2103241672 modified "2023-10-06" @default.
• W2103241672 title "Interaction of myelin basic protein with artificial membranes. Parameters governing binding, aggregation and dissociation" @default.
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• W2103241672 doi "https://doi.org/10.1111/j.1432-1033.1993.tb17597.x" @default.
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