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• W2103244313 startingPage "2041" @default.
• W2103244313 abstract "Clinical trials have shown overlapping bare-metal stents provoke effective thrombus clot within the aneurysm sac and shrinkage of the aneurysm by directly regulating the hemodynamics. To gain insight into the hemodynamic mechanism of the technique, three cases of simplified thoracic aortic aneurysm models (with no stent, a single stent and two overlapped stents deployed within the aneurysm sac) were studied and compared in terms of time-varying velocity and shear rate, time-averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT). The results demonstrated that the overlapping stents' strategy was more effective in reducing the velocity of blood flow within the aneurysm, especially for the area near the aneurysm wall. Stenting induced a dramatic change trend of shear rate during the cardiac cycle, in which a very high shear rate (>10,000 s(-1)) during the systole and a quite low shear rate (<1000 s(-1)) during the diastole were observed, respectively. Moreover, reduced TAWSS and OSI and elevated RRT values were observed on the aneurysm wall after stent placement. The effects of stenting on the shear rate, TAWSS, OSI and RRT in the aneurysm would be significantly enhanced by two overlapped stents. The present findings therefore indicated that, the overlapping bare-metal stents can isolate the aneurysm effectively and may create a favorable hemodynamic environment provoking platelets activation and aggregation within the aneurysm, which may promote thrombus formation/growth there, hence contribute to degradation of the aneurysm." @default.
• W2103244313 created "2016-06-24" @default.
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• W2103244313 date "2015-07-01" @default.
• W2103244313 modified "2023-10-16" @default.
• W2103244313 title "Hemodynamic insight into overlapping bare-metal stents strategy in the treatment of aortic aneurysm" @default.
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• W2103244313 doi "https://doi.org/10.1016/j.jbiomech.2015.03.028" @default.
• W2103244313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25911250" @default.
• W2103244313 hasPublicationYear "2015" @default.
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