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- W2103244464 endingPage "154" @default.
- W2103244464 startingPage "143" @default.
- W2103244464 abstract "Clinical, experimental and epidemiological research has shown the undeniable causal relationship between low HDL plasma concentrations and cardiovascular disease. Low HDL levels are present in about 10% of the general population and represent the most frequent form of dyslipidemia in patients with coronary disease. Reduced HDL concentrations seem to be unable to eliminate efficiently the cholesterol excess at vascular wall level, contributing to the onset of the inflammatory response that typically occurs in the pathogenesis of atherosclerosis right from its earliest stages. The results of numerous studies quite convincingly suggest that HDL is capable of exerting anti-inflammatory activity either directly or by modulating the expression of a number of acute phase proteins. Although the therapeutic options currently available for raising HDL levels still show modest efficacy, both in experimental and pre-clinical fields, genetic investigation and specifically aimed pharmacological treatment have produced more encouraging results, shedding some light on the concrete possibility of being able to treat this disease in the very near future." @default.
- W2103244464 created "2016-06-24" @default.
- W2103244464 creator A5006364964 @default.
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- W2103244464 creator A5060513215 @default.
- W2103244464 creator A5069720823 @default.
- W2103244464 creator A5086218234 @default.
- W2103244464 date "2006-04-01" @default.
- W2103244464 modified "2023-10-16" @default.
- W2103244464 title "HDL: The ‘new’ target of cardiovascular medicine" @default.
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