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• W2103248777 endingPage "14160" @default.
• W2103248777 startingPage "14149" @default.
• W2103248777 abstract "ABSTRACT Alpha/beta interferon (IFN-α/β) protects the host from virus infection by inhibition of lytic virus replication in infected cells and modulation of the antiviral cell-mediated immune response. To determine whether IFN-α/β also modulates the virus-host interaction during latent virus infection, we infected mice lacking the IFN-α/β receptor (IFN-α/βR −/− ) and wild-type (wt; 129S2/SvPas) mice with murine gammaherpesvirus 68 (γHV68), a lymphotropic gamma-2-herpesvirus that establishes latent infection in B cells, macrophages, and dendritic cells. IFN-α/βR −/− mice cleared low-dose intranasal γHV68 infection with wt kinetics and harbored essentially wt frequencies of latently infected cells in both peritoneum and spleen by 28 days postinfection. However, latent virus in peritoneal cells and splenocytes from IFN-α/βR −/− mice reactivated ex vivo with >40-fold- and 5-fold-enhanced efficiency, respectively, compared to wt cells. Depletion of IFN-α/β from wt mice during viral latency also significantly increased viral reactivation, demonstrating an antiviral function of IFN-α/β during latency. Viral reactivation efficiency was temporally regulated in both wt and IFN-α/βR −/− mice. The mechanism of IFN-α/βR action was distinct from that of IFN-γR, since IFN-α/βR −/− mice did not display persistent virus replication in vivo. Analysis of viral latent gene expression in vivo demonstrated specific upregulation of the latency-associated gene M2, which is required for efficient reactivation from latency, in IFN-α/βR −/− splenocytes. These data demonstrate that an IFN-α/β-induced pathway regulates γHV68 gene expression patterns during latent viral infection in vivo and that IFN-α/β plays a critical role in inhibiting viral reactivation during latency." @default.
• W2103248777 created "2016-06-24" @default.
• W2103248777 creator A5000978636 @default.
• W2103248777 creator A5003146388 @default.
• W2103248777 creator A5042031712 @default.
• W2103248777 creator A5073691312 @default.
• W2103248777 date "2005-11-15" @default.
• W2103248777 modified "2023-10-06" @default.
• W2103248777 title "Alpha/Beta Interferons Regulate Murine Gammaherpesvirus Latent Gene Expression and Reactivation from Latency" @default.
• W2103248777 cites W104228566 @default.
• W2103248777 cites W123913429 @default.
• W2103248777 cites W13039502 @default.
• W2103248777 cites W14497708 @default.
• W2103248777 cites W1480946340 @default.
• W2103248777 cites W1482408448 @default.
• W2103248777 cites W1517310071 @default.
• W2103248777 cites W1554047286 @default.
• W2103248777 cites W1558470647 @default.
• W2103248777 cites W1578274427 @default.
• W2103248777 cites W1579443490 @default.
• W2103248777 cites W1609504261 @default.
• W2103248777 cites W1674251039 @default.
• W2103248777 cites W1802351933 @default.
• W2103248777 cites W1886437674 @default.
• W2103248777 cites W1891937459 @default.
• W2103248777 cites W1935097178 @default.
• W2103248777 cites W1968134447 @default.
• W2103248777 cites W1975764372 @default.
• W2103248777 cites W1976826286 @default.
• W2103248777 cites W1978741561 @default.
• W2103248777 cites W1980394089 @default.
• W2103248777 cites W1988795205 @default.
• W2103248777 cites W1990386824 @default.
• W2103248777 cites W1992258294 @default.
• W2103248777 cites W1992794757 @default.
• W2103248777 cites W1997346264 @default.
• W2103248777 cites W1997614771 @default.
• W2103248777 cites W1997691172 @default.
• W2103248777 cites W2000031391 @default.
• W2103248777 cites W2000421708 @default.
• W2103248777 cites W2004101628 @default.
• W2103248777 cites W2004829503 @default.
• W2103248777 cites W2005081501 @default.
• W2103248777 cites W2009802110 @default.
• W2103248777 cites W2011205394 @default.
• W2103248777 cites W2011678998 @default.
• W2103248777 cites W2012258036 @default.
• W2103248777 cites W2015097600 @default.
• W2103248777 cites W2016525911 @default.
• W2103248777 cites W2018408523 @default.
• W2103248777 cites W2018890362 @default.
• W2103248777 cites W2034736009 @default.
• W2103248777 cites W2034869340 @default.
• W2103248777 cites W2037290021 @default.
• W2103248777 cites W2044117228 @default.
• W2103248777 cites W2046083652 @default.
• W2103248777 cites W2047391267 @default.
• W2103248777 cites W2051260092 @default.
• W2103248777 cites W2052521175 @default.
• W2103248777 cites W2055279578 @default.
• W2103248777 cites W2056305383 @default.
• W2103248777 cites W2065183510 @default.
• W2103248777 cites W2065866793 @default.
• W2103248777 cites W2072075206 @default.
• W2103248777 cites W2072701951 @default.
• W2103248777 cites W2075272059 @default.
• W2103248777 cites W2078319759 @default.
• W2103248777 cites W2088149899 @default.
• W2103248777 cites W2091055845 @default.
• W2103248777 cites W2091087071 @default.
• W2103248777 cites W2099019634 @default.
• W2103248777 cites W2101894411 @default.
• W2103248777 cites W2102701329 @default.
• W2103248777 cites W2103565638 @default.
• W2103248777 cites W2111656409 @default.
• W2103248777 cites W2113180936 @default.
• W2103248777 cites W2114173013 @default.
• W2103248777 cites W2115054658 @default.
• W2103248777 cites W2119542365 @default.
• W2103248777 cites W2122121713 @default.
• W2103248777 cites W2122506044 @default.
• W2103248777 cites W2124580614 @default.
• W2103248777 cites W2128048082 @default.
• W2103248777 cites W2131933513 @default.
• W2103248777 cites W2134321753 @default.
• W2103248777 cites W2135401259 @default.
• W2103248777 cites W2136287414 @default.
• W2103248777 cites W2136909373 @default.
• W2103248777 cites W2136951199 @default.
• W2103248777 cites W2137247857 @default.
• W2103248777 cites W2141149056 @default.
• W2103248777 cites W2141660858 @default.
• W2103248777 cites W2142266630 @default.
• W2103248777 cites W2142903473 @default.
• W2103248777 cites W2145480908 @default.
• W2103248777 cites W2146312821 @default.
• W2103248777 cites W2146375964 @default.
• W2103248777 cites W2147986058 @default.

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