Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103248995> ?p ?o ?g. }
- W2103248995 endingPage "1588" @default.
- W2103248995 startingPage "1580" @default.
- W2103248995 abstract "We generated draft genome sequences for two cold-adapted Archaea, Methanogenium frigidum and Methanococcoides burtonii , to identify genotypic characteristics that distinguish them from Archaea with a higher optimal growth temperature (OGT). Comparative genomics revealed trends in amino acid and tRNA composition, and structural features of proteins. Proteins from the cold-adapted Archaea are characterized by a higher content of noncharged polar amino acids, particularly Gln and Thr and a lower content of hydrophobic amino acids, particularly Leu. Sequence data from nine methanogen genomes (OGT 15°–98°C) were used to generate 1111 modeled protein structures. Analysis of the models from the cold-adapted Archaea showed a strong tendency in the solvent-accessible area for more Gln, Thr, and hydrophobic residues and fewer charged residues. A cold shock domain (CSD) protein (CspA homolog) was identified in M. frigidum , two hypothetical proteins with CSD-folds in M. burtonii , and a unique winged helix DNA-binding domain protein in M. burtonii . This suggests that these types of nucleic acid binding proteins have a critical role in cold-adapted Archaea . Structural analysis of tRNA sequences from the Archaea indicated that GC content is the major factor influencing tRNA stability in hyperthermophiles, but not in the psychrophiles, mesophiles or moderate thermophiles. Below an OGT of 60°C, the GC content in tRNA was largely unchanged, indicating that any requirement for flexibility of tRNA in psychrophiles is mediated by other means. This is the first time that comparisons have been performed with genome data from Archaea spanning the growth temperature extremes from psychrophiles to hyperthermophiles." @default.
- W2103248995 created "2016-06-24" @default.
- W2103248995 creator A5000432538 @default.
- W2103248995 creator A5002282632 @default.
- W2103248995 creator A5011194879 @default.
- W2103248995 creator A5012708102 @default.
- W2103248995 creator A5013558711 @default.
- W2103248995 creator A5019397017 @default.
- W2103248995 creator A5023503730 @default.
- W2103248995 creator A5023828670 @default.
- W2103248995 creator A5027821717 @default.
- W2103248995 creator A5031688105 @default.
- W2103248995 creator A5037059882 @default.
- W2103248995 creator A5045158875 @default.
- W2103248995 creator A5046291599 @default.
- W2103248995 creator A5049548879 @default.
- W2103248995 creator A5051874360 @default.
- W2103248995 creator A5059683077 @default.
- W2103248995 creator A5072115247 @default.
- W2103248995 creator A5075143402 @default.
- W2103248995 creator A5075543149 @default.
- W2103248995 creator A5078073876 @default.
- W2103248995 creator A5082832349 @default.
- W2103248995 creator A5086975931 @default.
- W2103248995 creator A5087939818 @default.
- W2103248995 creator A5088030110 @default.
- W2103248995 creator A5089413692 @default.
- W2103248995 date "2003-06-12" @default.
- W2103248995 modified "2023-10-16" @default.
- W2103248995 title "Mechanisms of Thermal Adaptation Revealed From the Genomes of the Antarctic <i>Archaea Methanogenium frigidum</i> and <i>Methanococcoides burtonii</i>" @default.
- W2103248995 cites W1486836403 @default.
- W2103248995 cites W1543796220 @default.
- W2103248995 cites W1590768340 @default.
- W2103248995 cites W1672694014 @default.
- W2103248995 cites W1947962930 @default.
- W2103248995 cites W1965110762 @default.
- W2103248995 cites W1969435183 @default.
- W2103248995 cites W1969698996 @default.
- W2103248995 cites W1981141378 @default.
- W2103248995 cites W1982561534 @default.
- W2103248995 cites W1984753553 @default.
- W2103248995 cites W1999668682 @default.
- W2103248995 cites W2008708467 @default.
- W2103248995 cites W2012899254 @default.
- W2103248995 cites W2013455102 @default.
- W2103248995 cites W2016889496 @default.
- W2103248995 cites W2019940850 @default.
- W2103248995 cites W2028360015 @default.
- W2103248995 cites W2031834810 @default.
- W2103248995 cites W2037877622 @default.
- W2103248995 cites W2045198143 @default.
- W2103248995 cites W2053150867 @default.
- W2103248995 cites W2059350145 @default.
- W2103248995 cites W2062232288 @default.
- W2103248995 cites W2069930433 @default.
- W2103248995 cites W2074993978 @default.
- W2103248995 cites W2077303444 @default.
- W2103248995 cites W2085277871 @default.
- W2103248995 cites W2086341407 @default.
- W2103248995 cites W2087158203 @default.
- W2103248995 cites W2094326096 @default.
- W2103248995 cites W2101971141 @default.
- W2103248995 cites W2105840826 @default.
- W2103248995 cites W2105923547 @default.
- W2103248995 cites W2106269045 @default.
- W2103248995 cites W2106395711 @default.
- W2103248995 cites W2109446129 @default.
- W2103248995 cites W2110850678 @default.
- W2103248995 cites W2113622844 @default.
- W2103248995 cites W2114520383 @default.
- W2103248995 cites W2119492036 @default.
- W2103248995 cites W2121016876 @default.
- W2103248995 cites W2125624231 @default.
- W2103248995 cites W2128967322 @default.
- W2103248995 cites W2133253129 @default.
- W2103248995 cites W2140860400 @default.
- W2103248995 cites W2145034001 @default.
- W2103248995 cites W2148131811 @default.
- W2103248995 cites W2149429041 @default.
- W2103248995 cites W2150934173 @default.
- W2103248995 cites W2153901638 @default.
- W2103248995 cites W2169929748 @default.
- W2103248995 cites W220526125 @default.
- W2103248995 cites W4229880569 @default.
- W2103248995 cites W4239833500 @default.
- W2103248995 cites W4250052351 @default.
- W2103248995 cites W4252046103 @default.
- W2103248995 cites W4256395558 @default.
- W2103248995 doi "https://doi.org/10.1101/gr.1180903" @default.
- W2103248995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/403754" @default.
- W2103248995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12805271" @default.
- W2103248995 hasPublicationYear "2003" @default.
- W2103248995 type Work @default.
- W2103248995 sameAs 2103248995 @default.
- W2103248995 citedByCount "244" @default.
- W2103248995 countsByYear W21032489952012 @default.
- W2103248995 countsByYear W21032489952013 @default.
- W2103248995 countsByYear W21032489952014 @default.