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• W2103249653 endingPage "18" @default.
• W2103249653 startingPage "1" @default.
• W2103249653 abstract "Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. We report on the expression of the inflammatory and homeostatic CKR on normal blood<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>CD16 + and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>high</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math> <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD16</mml:mtext></mml:mrow><mml:mrow><mml:mo>-</mml:mo><mml:mo>/</mml:mo><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells. Conventional<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>high</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patterns<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells are mainly CXCR1/CXCR2 + and CXCR3/CCR5 −/+ , whereas mostly<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>high</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells are CXCR1/CXCR2 − and CXCR3/CCR5 + . Both NK-cell subsets have variable CXCR4 expression and are CCR4 − and CCR6 − . The CKR repertoire of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells approaches to that of neutrophils, whereas the CKR repertoire of the<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>high</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells mimics that of Th1 + T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response. In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we named<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>int</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells. These NK-cells are CXCR3/CCR5 + , they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57 − and CD158a − . In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-known<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>high</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD56</mml:mtext></mml:mrow><mml:mrow><mml:mo>+</mml:mo><mml:mtext>low</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>NK-cells populations." @default.
• W2103249653 created "2016-06-24" @default.
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• W2103249653 date "2015-01-01" @default.
• W2103249653 modified "2023-09-24" @default.
• W2103249653 title "Chemokine Receptor Expression on Normal Blood CD56⁺NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population" @default.
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