Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103251875> ?p ?o ?g. }
- W2103251875 endingPage "7932" @default.
- W2103251875 startingPage "7922" @default.
- W2103251875 abstract "The fission yeast Hsk1p kinase is an essential activator of DNA replication. Here we report the isolation and characterization of a novel mutant allele of the gene. Consistent with its role in the initiation of DNA synthesis, hsk1ts genetically interacts with several S-phase mutants. At the restrictive temperature,hsk1ts cells suffer abnormal S phase and loss of nuclear integrity and are sensitive to both DNA-damaging agents and replication arrest. Interestingly, hsk1tsmutants released to the restrictive temperature after early S-phase arrest in hydroxyurea (HU) are able to complete bulk DNA synthesis but they nevertheless undergo an abnormal mitosis. These findings indicate a second role for hsk1 subsequent to HU arrest. Consistent with a later S-phase role, hsk1ts is synthetically lethal with Δrqh1 (RecQ helicase) orrad21ts (cohesin) mutants and suppressed by Δcds1 (RAD53 kinase) mutants. We demonstrate that Hsk1p undergoes Cds1p-dependent phosphorylation in response to HU and that it is a direct substrate of purified Cds1p kinase in vitro. These results indicate that the Hsk1p kinase is a potential target of Cds1p regulation and that its activity is required after replication initiation for normal mitosis." @default.
- W2103251875 created "2016-06-24" @default.
- W2103251875 creator A5016762566 @default.
- W2103251875 creator A5068240576 @default.
- W2103251875 creator A5069152548 @default.
- W2103251875 date "2000-11-01" @default.
- W2103251875 modified "2023-09-27" @default.
- W2103251875 title "<i>Schizosaccharomyces pombe </i>Hsk1p Is a Potential Cds1p Target Required for Genome Integrity" @default.
- W2103251875 cites W109358480 @default.
- W2103251875 cites W144989806 @default.
- W2103251875 cites W1522668252 @default.
- W2103251875 cites W1566625041 @default.
- W2103251875 cites W1597133026 @default.
- W2103251875 cites W1797275993 @default.
- W2103251875 cites W1870502238 @default.
- W2103251875 cites W1873149314 @default.
- W2103251875 cites W1918937128 @default.
- W2103251875 cites W1977518145 @default.
- W2103251875 cites W1980561563 @default.
- W2103251875 cites W1981851148 @default.
- W2103251875 cites W1992543471 @default.
- W2103251875 cites W1994909028 @default.
- W2103251875 cites W2002755671 @default.
- W2103251875 cites W2011498074 @default.
- W2103251875 cites W2014611447 @default.
- W2103251875 cites W2026061099 @default.
- W2103251875 cites W2027517946 @default.
- W2103251875 cites W2029491802 @default.
- W2103251875 cites W2032327949 @default.
- W2103251875 cites W2039576441 @default.
- W2103251875 cites W2041834021 @default.
- W2103251875 cites W2043232323 @default.
- W2103251875 cites W2046707499 @default.
- W2103251875 cites W2056205588 @default.
- W2103251875 cites W2057785888 @default.
- W2103251875 cites W2059014851 @default.
- W2103251875 cites W2065529829 @default.
- W2103251875 cites W2073359663 @default.
- W2103251875 cites W2079711691 @default.
- W2103251875 cites W2089639192 @default.
- W2103251875 cites W2091782725 @default.
- W2103251875 cites W2104460448 @default.
- W2103251875 cites W2105844987 @default.
- W2103251875 cites W2110513450 @default.
- W2103251875 cites W2110629065 @default.
- W2103251875 cites W2110740129 @default.
- W2103251875 cites W2115954499 @default.
- W2103251875 cites W2117301813 @default.
- W2103251875 cites W2120917736 @default.
- W2103251875 cites W2125498284 @default.
- W2103251875 cites W2126941299 @default.
- W2103251875 cites W2129781454 @default.
- W2103251875 cites W2131519801 @default.
- W2103251875 cites W2132459498 @default.
- W2103251875 cites W2134927450 @default.
- W2103251875 cites W2142757231 @default.
- W2103251875 cites W2147971204 @default.
- W2103251875 cites W2148348950 @default.
- W2103251875 cites W2152414953 @default.
- W2103251875 cites W2161868517 @default.
- W2103251875 cites W2162431562 @default.
- W2103251875 cites W2167813188 @default.
- W2103251875 cites W2183595347 @default.
- W2103251875 cites W2187707391 @default.
- W2103251875 cites W2194986544 @default.
- W2103251875 cites W2308586243 @default.
- W2103251875 cites W291368850 @default.
- W2103251875 cites W4295216797 @default.
- W2103251875 doi "https://doi.org/10.1128/mcb.20.21.7922-7932.2000" @default.
- W2103251875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/86403" @default.
- W2103251875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11027263" @default.
- W2103251875 hasPublicationYear "2000" @default.
- W2103251875 type Work @default.
- W2103251875 sameAs 2103251875 @default.
- W2103251875 citedByCount "82" @default.
- W2103251875 countsByYear W21032518752012 @default.
- W2103251875 countsByYear W21032518752013 @default.
- W2103251875 countsByYear W21032518752014 @default.
- W2103251875 countsByYear W21032518752015 @default.
- W2103251875 countsByYear W21032518752016 @default.
- W2103251875 countsByYear W21032518752017 @default.
- W2103251875 countsByYear W21032518752018 @default.
- W2103251875 countsByYear W21032518752019 @default.
- W2103251875 countsByYear W21032518752020 @default.
- W2103251875 countsByYear W21032518752021 @default.
- W2103251875 countsByYear W21032518752022 @default.
- W2103251875 crossrefType "journal-article" @default.
- W2103251875 hasAuthorship W2103251875A5016762566 @default.
- W2103251875 hasAuthorship W2103251875A5068240576 @default.
- W2103251875 hasAuthorship W2103251875A5069152548 @default.
- W2103251875 hasBestOaLocation W21032518752 @default.
- W2103251875 hasConcept C104317684 @default.
- W2103251875 hasConcept C104690221 @default.
- W2103251875 hasConcept C134935766 @default.
- W2103251875 hasConcept C143065580 @default.
- W2103251875 hasConcept C143425029 @default.
- W2103251875 hasConcept C153911025 @default.
- W2103251875 hasConcept C161223559 @default.