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- W2103256870 abstract "Mesoscopic coarse‐grained simulations are adopted to investigate interfacial mechanisms of hydrophobic charged induction chromatography for protein purification by regulating pH. Simulations results indicate that: (i) lysozyme can be adsorbed mainly with “top end‐on” and “bottom end‐on” orientation on hydrophobic surfaces, dominated by the two hydrophobic regions located at both ends of lysozyme's long axis. Elution from the “top end‐on” orientation is more difficult than that from the “bottom end‐on” orientation; (ii) a higher ligand density can get a faster adsorption rate and stronger adsorption. Interestingly, the effect of ligand density on the desorption is mainly determined by the distribution probability of the positively charged groups of ligands; (iii) a higher ionic strength can lead to a wider orientation distribution, a stronger adsorption and a lower elution rate. This work might provide an efficient way to optimize the operating conditions and designing novel ligands. © 2015 American Institute of Chemical Engineers AIChE J , 61: 2035–2047, 2015" @default.
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- W2103256870 date "2015-04-08" @default.
- W2103256870 modified "2023-10-18" @default.
- W2103256870 title "Mesoscopic coarse-grained simulations of hydrophobic charge induction chromatography (HCIC) for protein purification" @default.
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- W2103256870 doi "https://doi.org/10.1002/aic.14805" @default.
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