FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103257088> ?p ?o ?g. }

• W2103257088 endingPage "8988" @default.
• W2103257088 startingPage "8979" @default.
• W2103257088 abstract "The induction and inhibition of the interferon (IFN) response and apoptosis by bovine viral diarrhea virus (BVDV) has been examined. Here we show that prior infection of cells by noncytopathogenic BVDV (ncp BVDV) fails to block transcriptional responses to alpha/beta IFN. In contrast, ncp BVDV-infected cells fail to produce IFN-alpha/beta or MxA in response to double-stranded RNA (dsRNA) or infection with a heterologous virus (Semliki Forest virus [SFV]). ncp BVDV preinfection is unable to block cp BVDV- or SFV-induced apoptosis. The effects of ncp BVDV infection on the transcription factors controlling the IFN-beta induction pathway have been analyzed. The transcription factor NF-kappa B was not activated following ncp BVDV infection, but ncp BVDV infection was not able to block the activation of NF-kappa B by either SFV or tumor necrosis factor alpha. Furthermore, ncp BVDV infection did not result in the activation of stress kinases (JNK1 and JNK2) or the phosphorylation of transcription factors ATF-2 and c-Jun; again, ncp BVDV infection was not able to block their activation by SFV. Interferon regulatory factor 3 (IRF-3) was shown to be translocated to the nuclei of infected cells in response to ncp BVDV, although DNA-binding of IRF-3 was not seen in nuclear extracts. In contrast, an IRF-3-DNA complex was observed in nuclear extracts from cells infected with SFV, but the appearance of this complex was blocked when cells were previously exposed to ncp BVDV. We conclude that the inhibition of IFN induction by this pestivirus involves a block to IRF-3 function, and we speculate that this may be a key characteristic for the survival of pestiviruses in nature." @default.
• W2103257088 created "2016-06-24" @default.
• W2103257088 creator A5029522995 @default.
• W2103257088 creator A5043267123 @default.
• W2103257088 creator A5046811172 @default.
• W2103257088 creator A5059397877 @default.
• W2103257088 creator A5088609944 @default.
• W2103257088 creator A5089001017 @default.
• W2103257088 date "2002-09-15" @default.
• W2103257088 modified "2023-09-26" @default.
• W2103257088 title "Inhibition of Beta Interferon Transcription by Noncytopathogenic Bovine Viral Diarrhea Virus Is through an Interferon Regulatory Factor 3-Dependent Mechanism" @default.
• W2103257088 cites W1549898711 @default.
• W2103257088 cites W1866683333 @default.
• W2103257088 cites W1890314278 @default.
• W2103257088 cites W1895691188 @default.
• W2103257088 cites W1958878736 @default.
• W2103257088 cites W1972576763 @default.
• W2103257088 cites W1976862171 @default.
• W2103257088 cites W1977457899 @default.
• W2103257088 cites W1982170462 @default.
• W2103257088 cites W2001804120 @default.
• W2103257088 cites W2002301799 @default.
• W2103257088 cites W2006558753 @default.
• W2103257088 cites W2010187839 @default.
• W2103257088 cites W2011330612 @default.
• W2103257088 cites W2017309788 @default.
• W2103257088 cites W2018948406 @default.
• W2103257088 cites W2024278937 @default.
• W2103257088 cites W2025246568 @default.
• W2103257088 cites W2036138435 @default.
• W2103257088 cites W2047739035 @default.
• W2103257088 cites W2048235174 @default.
• W2103257088 cites W2058080941 @default.
• W2103257088 cites W2060083709 @default.
• W2103257088 cites W2060452768 @default.
• W2103257088 cites W2067438899 @default.
• W2103257088 cites W2068895548 @default.
• W2103257088 cites W2069384122 @default.
• W2103257088 cites W2080735630 @default.
• W2103257088 cites W2086882580 @default.
• W2103257088 cites W2095194341 @default.
• W2103257088 cites W2097447335 @default.
• W2103257088 cites W2104144111 @default.
• W2103257088 cites W2104777676 @default.
• W2103257088 cites W2108399976 @default.
• W2103257088 cites W2121284065 @default.
• W2103257088 cites W2130576390 @default.
• W2103257088 cites W2137283942 @default.
• W2103257088 cites W2139405922 @default.
• W2103257088 cites W2150665726 @default.
• W2103257088 cites W2151064612 @default.
• W2103257088 cites W2153232013 @default.
• W2103257088 cites W2156947910 @default.
• W2103257088 cites W2167516676 @default.
• W2103257088 cites W2320947107 @default.
• W2103257088 cites W2409555062 @default.
• W2103257088 cites W2410025767 @default.
• W2103257088 cites W2416566044 @default.
• W2103257088 cites W4250958726 @default.
• W2103257088 cites W9610411 @default.
• W2103257088 doi "https://doi.org/10.1128/jvi.76.18.8979-8988.2002" @default.
• W2103257088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136435" @default.
• W2103257088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12186882" @default.
• W2103257088 hasPublicationYear "2002" @default.
• W2103257088 type Work @default.
• W2103257088 sameAs 2103257088 @default.
• W2103257088 citedByCount "130" @default.
• W2103257088 countsByYear W21032570882012 @default.
• W2103257088 countsByYear W21032570882013 @default.
• W2103257088 countsByYear W21032570882014 @default.
• W2103257088 countsByYear W21032570882015 @default.
• W2103257088 countsByYear W21032570882016 @default.
• W2103257088 countsByYear W21032570882017 @default.
• W2103257088 countsByYear W21032570882018 @default.
• W2103257088 countsByYear W21032570882019 @default.
• W2103257088 countsByYear W21032570882020 @default.
• W2103257088 countsByYear W21032570882021 @default.
• W2103257088 countsByYear W21032570882022 @default.
• W2103257088 countsByYear W21032570882023 @default.
• W2103257088 crossrefType "journal-article" @default.
• W2103257088 hasAuthorship W2103257088A5029522995 @default.
• W2103257088 hasAuthorship W2103257088A5043267123 @default.
• W2103257088 hasAuthorship W2103257088A5046811172 @default.
• W2103257088 hasAuthorship W2103257088A5059397877 @default.
• W2103257088 hasAuthorship W2103257088A5088609944 @default.
• W2103257088 hasAuthorship W2103257088A5089001017 @default.
• W2103257088 hasBestOaLocation W21032570881 @default.
• W2103257088 hasConcept C104317684 @default.
• W2103257088 hasConcept C153911025 @default.
• W2103257088 hasConcept C159047783 @default.
• W2103257088 hasConcept C2522874641 @default.
• W2103257088 hasConcept C2776178377 @default.
• W2103257088 hasConcept C2780963514 @default.
• W2103257088 hasConcept C55493867 @default.
• W2103257088 hasConcept C67705224 @default.
• W2103257088 hasConcept C86339819 @default.
• W2103257088 hasConcept C86803240 @default.
• W2103257088 hasConcept C9173399 @default.

• next