Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103258118> ?p ?o ?g. }
- W2103258118 endingPage "50" @default.
- W2103258118 startingPage "37" @default.
- W2103258118 abstract "The molecular chaperone Hsp90 is a protein with important roles in maintaining the functional stability and viability of cells under a transforming pressure. Cancer cells harbour mutated oncogenic proteins or proteins with dysregulated function and the chaperone is required to maintain their folded and functionally active conformation. In addition, by chaperoning key proteins such as Raf-1, Akt, survivin and hTERT, Hsp90 regulates signalling pathways necessary for the growth, survival and limitless replicative potential of most tumours. Important elements of the apoptotic pathways are also regulated by Hsp90. Overall, these characteristics propose Hsp90 as an important target of whose inhibition may aim at a wide-range of oncogenic transformations. Several years into Hsp90 research have shed light into the feasibility, but also the limitations, of such an approach. In this review, the authors present the current understanding on the relevance and possibility of translating Hsp90 inhibitors into therapeutic agents in cancer therapy." @default.
- W2103258118 created "2016-06-24" @default.
- W2103258118 creator A5040925962 @default.
- W2103258118 date "2006-01-27" @default.
- W2103258118 modified "2023-09-23" @default.
- W2103258118 title "Targeting chaperones in transformed systems – a focus on Hsp90 and cancer" @default.
- W2103258118 cites W142850513 @default.
- W2103258118 cites W1489973637 @default.
- W2103258118 cites W1515506492 @default.
- W2103258118 cites W1554180547 @default.
- W2103258118 cites W1586440254 @default.
- W2103258118 cites W1607384859 @default.
- W2103258118 cites W1607745684 @default.
- W2103258118 cites W1967535631 @default.
- W2103258118 cites W1967859462 @default.
- W2103258118 cites W1969130149 @default.
- W2103258118 cites W1969537147 @default.
- W2103258118 cites W1970177198 @default.
- W2103258118 cites W1970393904 @default.
- W2103258118 cites W1971190195 @default.
- W2103258118 cites W1972045191 @default.
- W2103258118 cites W1976065095 @default.
- W2103258118 cites W1976980728 @default.
- W2103258118 cites W1980282046 @default.
- W2103258118 cites W1986088839 @default.
- W2103258118 cites W1986242330 @default.
- W2103258118 cites W1988219667 @default.
- W2103258118 cites W1988692190 @default.
- W2103258118 cites W1988825409 @default.
- W2103258118 cites W1990011854 @default.
- W2103258118 cites W1992909271 @default.
- W2103258118 cites W1995486038 @default.
- W2103258118 cites W1995857669 @default.
- W2103258118 cites W1999307044 @default.
- W2103258118 cites W2000929246 @default.
- W2103258118 cites W2001710697 @default.
- W2103258118 cites W2004313928 @default.
- W2103258118 cites W2007501972 @default.
- W2103258118 cites W2012046660 @default.
- W2103258118 cites W2012520981 @default.
- W2103258118 cites W2012828386 @default.
- W2103258118 cites W2014514145 @default.
- W2103258118 cites W2014573616 @default.
- W2103258118 cites W2018343730 @default.
- W2103258118 cites W2020742237 @default.
- W2103258118 cites W2021227263 @default.
- W2103258118 cites W2021534705 @default.
- W2103258118 cites W2022471909 @default.
- W2103258118 cites W2022531767 @default.
- W2103258118 cites W2026836017 @default.
- W2103258118 cites W2028321505 @default.
- W2103258118 cites W2031862653 @default.
- W2103258118 cites W2032157282 @default.
- W2103258118 cites W2042502745 @default.
- W2103258118 cites W2042699875 @default.
- W2103258118 cites W2043597034 @default.
- W2103258118 cites W2046639009 @default.
- W2103258118 cites W2053443882 @default.
- W2103258118 cites W2053503219 @default.
- W2103258118 cites W2054290614 @default.
- W2103258118 cites W2058018033 @default.
- W2103258118 cites W2059524588 @default.
- W2103258118 cites W2059901120 @default.
- W2103258118 cites W2062652157 @default.
- W2103258118 cites W2062804260 @default.
- W2103258118 cites W2066264348 @default.
- W2103258118 cites W2069816360 @default.
- W2103258118 cites W2074188486 @default.
- W2103258118 cites W2074579328 @default.
- W2103258118 cites W2075805324 @default.
- W2103258118 cites W2076544158 @default.
- W2103258118 cites W2082390299 @default.
- W2103258118 cites W2082717401 @default.
- W2103258118 cites W2083890417 @default.
- W2103258118 cites W2084736894 @default.
- W2103258118 cites W2085643470 @default.
- W2103258118 cites W2086185470 @default.
- W2103258118 cites W2091516551 @default.
- W2103258118 cites W2091973193 @default.
- W2103258118 cites W2096088010 @default.
- W2103258118 cites W2097513203 @default.
- W2103258118 cites W2100611890 @default.
- W2103258118 cites W2101457798 @default.
- W2103258118 cites W2104749830 @default.
- W2103258118 cites W2105845590 @default.
- W2103258118 cites W2107789276 @default.
- W2103258118 cites W2108230631 @default.
- W2103258118 cites W2112417555 @default.
- W2103258118 cites W2113007147 @default.
- W2103258118 cites W2113184090 @default.
- W2103258118 cites W2114173273 @default.
- W2103258118 cites W2118509212 @default.
- W2103258118 cites W2119874123 @default.
- W2103258118 cites W2125634299 @default.
- W2103258118 cites W2134175129 @default.
- W2103258118 cites W2136276051 @default.
- W2103258118 cites W2137355642 @default.
- W2103258118 cites W2139306838 @default.