Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103261343> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2103261343 abstract "Cathepsin K is a recently discovered member of the papain superfamily of cysteine proteinases. This enzyme is highly expressed in human osteoclast cells where it plays an important role in the resorption processes in normal bone remodelling. The importance of cathepsin K in osteoclast-mediated resorption of the bone matrix provides a rationale for the design of inhibitors of cathepsin K as potential drugs for the treatment of diseases of excess bone remodelling such as osteoporosis. Successful application of modern methods of drug discovery, including genomics and structure-based methods of drug design, has resulted in the identification of this previously unknown therapeutic target and the rapid elucidation of novel, potent and selective inhibitors of human osteoclast cathepsin K. Several classes of inhibitors of cathepsin K that have been reported in the published literature and in recent patent filings are described in this review." @default.
- W2103261343 created "2016-06-24" @default.
- W2103261343 creator A5056362769 @default.
- W2103261343 creator A5058256006 @default.
- W2103261343 date "1999-06-01" @default.
- W2103261343 modified "2023-09-24" @default.
- W2103261343 title "Cathepsin K as a target for the treatment of osteoporosis" @default.
- W2103261343 cites W1583830460 @default.
- W2103261343 cites W1968333574 @default.
- W2103261343 cites W1978804937 @default.
- W2103261343 cites W1990772088 @default.
- W2103261343 cites W1994641823 @default.
- W2103261343 cites W2011875568 @default.
- W2103261343 cites W2012931700 @default.
- W2103261343 cites W2015922674 @default.
- W2103261343 cites W2038422579 @default.
- W2103261343 cites W2049528994 @default.
- W2103261343 cites W2053168080 @default.
- W2103261343 cites W2058616210 @default.
- W2103261343 cites W2073485842 @default.
- W2103261343 cites W2078146467 @default.
- W2103261343 cites W2083294270 @default.
- W2103261343 cites W2087619448 @default.
- W2103261343 cites W2090177025 @default.
- W2103261343 cites W2090299301 @default.
- W2103261343 cites W2148574844 @default.
- W2103261343 cites W2155036500 @default.
- W2103261343 cites W2161115679 @default.
- W2103261343 doi "https://doi.org/10.1517/13543776.9.6.683" @default.
- W2103261343 hasPublicationYear "1999" @default.
- W2103261343 type Work @default.
- W2103261343 sameAs 2103261343 @default.
- W2103261343 citedByCount "16" @default.
- W2103261343 crossrefType "journal-article" @default.
- W2103261343 hasAuthorship W2103261343A5056362769 @default.
- W2103261343 hasAuthorship W2103261343A5058256006 @default.
- W2103261343 hasConcept C101990758 @default.
- W2103261343 hasConcept C126322002 @default.
- W2103261343 hasConcept C142724271 @default.
- W2103261343 hasConcept C167844969 @default.
- W2103261343 hasConcept C181199279 @default.
- W2103261343 hasConcept C185592680 @default.
- W2103261343 hasConcept C202751555 @default.
- W2103261343 hasConcept C2776033226 @default.
- W2103261343 hasConcept C2776541429 @default.
- W2103261343 hasConcept C34695024 @default.
- W2103261343 hasConcept C502942594 @default.
- W2103261343 hasConcept C55493867 @default.
- W2103261343 hasConcept C673006 @default.
- W2103261343 hasConcept C71924100 @default.
- W2103261343 hasConcept C74187038 @default.
- W2103261343 hasConcept C78553746 @default.
- W2103261343 hasConcept C86803240 @default.
- W2103261343 hasConcept C95444343 @default.
- W2103261343 hasConceptScore W2103261343C101990758 @default.
- W2103261343 hasConceptScore W2103261343C126322002 @default.
- W2103261343 hasConceptScore W2103261343C142724271 @default.
- W2103261343 hasConceptScore W2103261343C167844969 @default.
- W2103261343 hasConceptScore W2103261343C181199279 @default.
- W2103261343 hasConceptScore W2103261343C185592680 @default.
- W2103261343 hasConceptScore W2103261343C202751555 @default.
- W2103261343 hasConceptScore W2103261343C2776033226 @default.
- W2103261343 hasConceptScore W2103261343C2776541429 @default.
- W2103261343 hasConceptScore W2103261343C34695024 @default.
- W2103261343 hasConceptScore W2103261343C502942594 @default.
- W2103261343 hasConceptScore W2103261343C55493867 @default.
- W2103261343 hasConceptScore W2103261343C673006 @default.
- W2103261343 hasConceptScore W2103261343C71924100 @default.
- W2103261343 hasConceptScore W2103261343C74187038 @default.
- W2103261343 hasConceptScore W2103261343C78553746 @default.
- W2103261343 hasConceptScore W2103261343C86803240 @default.
- W2103261343 hasConceptScore W2103261343C95444343 @default.
- W2103261343 hasLocation W21032613431 @default.
- W2103261343 hasOpenAccess W2103261343 @default.
- W2103261343 hasPrimaryLocation W21032613431 @default.
- W2103261343 hasRelatedWork W1177042389 @default.
- W2103261343 hasRelatedWork W1519304950 @default.
- W2103261343 hasRelatedWork W1984965767 @default.
- W2103261343 hasRelatedWork W2025062557 @default.
- W2103261343 hasRelatedWork W2037541841 @default.
- W2103261343 hasRelatedWork W2055480930 @default.
- W2103261343 hasRelatedWork W2058616210 @default.
- W2103261343 hasRelatedWork W2060664648 @default.
- W2103261343 hasRelatedWork W2098479633 @default.
- W2103261343 hasRelatedWork W2111066407 @default.
- W2103261343 hasRelatedWork W2128047597 @default.
- W2103261343 hasRelatedWork W2132301735 @default.
- W2103261343 hasRelatedWork W2155036500 @default.
- W2103261343 hasRelatedWork W2160174421 @default.
- W2103261343 hasRelatedWork W2259430937 @default.
- W2103261343 hasRelatedWork W2359251729 @default.
- W2103261343 hasRelatedWork W2370844256 @default.
- W2103261343 hasRelatedWork W2589633033 @default.
- W2103261343 hasRelatedWork W3005131311 @default.
- W2103261343 hasRelatedWork W3023836853 @default.
- W2103261343 isParatext "false" @default.
- W2103261343 isRetracted "false" @default.
- W2103261343 magId "2103261343" @default.
- W2103261343 workType "article" @default.