FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103263214> ?p ?o ?g. }

• W2103263214 endingPage "595" @default.
• W2103263214 startingPage "583" @default.
• W2103263214 abstract "Background and purpose There is evidence that ocular blood flow plays a critical role in the clinical course of glaucoma. Hence a reduction in ocular blood flow due to topical antiglaucoma treatment should be avoided. The purpose of this study was to characterize the effect of antiglaucoma drugs on ocular hemodynamics. Methods In a double-blind, placebo-controlled, randomized crossover study, we investigated the effects of single topical doses of five β-blocking agents (befunolol, betaxolol, levobunolol, metipranolol, and timolol), two adrenergic agents (clonidine and dipivefrin [INN, dipivefrine]), and a parasympathomimetic agent (pilocarpine) on ocular and systemic hemodynamics in healthy subjects (n = 10). Fundus pulsation amplitudes in the macula and the optic disc were measured to characterize pulsatile choroidal and optic disc blood flow, respectively. Moreover, central retinal and ophthalmic artery blood flow velocities were measured by Doppler ultrasound. Results Befunolol, metipranolol, timolol, clonidine, and dipivefrin reduced fundus pulsations in the macula and the optic disc (−9% to −14% versus baseline). In contrast, betaxolol, levobunolol, and pilocarpine had no effect on fundus pulsations. Antiglaucoma drugs had no effect on either blood flow velocities in the central retinal or the ophthalmic artery or systemic hemodynamics. Conclusions Our results indicate that befunolol, metipranolol, timolol, clonidine, and dipivefrin reduce choroidal and optic disc blood flow. This could be caused by drug diffusion to the choroid, which may cause vasoconstriction. Ocular blood flow reduction was not observed with betaxolol, levobunolol, or pilocarpine. The lack of effect of all drugs under study on central retinal blood flow velocity might partially be the result of autoregulative mechanisms. Because optic nerve head blood flow likely plays a critical role in the clinical course of glaucoma, the use of antiglaucoma drugs, which reduce blood flow, should be reconsidered. Clinical Pharmacology & Therapeutics (1997) 61, 583–595; doi:" @default.
• W2103263214 created "2016-06-24" @default.
• W2103263214 creator A5007495122 @default.
• W2103263214 creator A5015017045 @default.
• W2103263214 creator A5021151100 @default.
• W2103263214 creator A5054404247 @default.
• W2103263214 creator A5054781284 @default.
• W2103263214 creator A5067571671 @default.
• W2103263214 creator A5081525159 @default.
• W2103263214 creator A5082232461 @default.
• W2103263214 date "1997-05-01" @default.
• W2103263214 modified "2023-10-18" @default.
• W2103263214 title "Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers" @default.
• W2103263214 cites W1567326705 @default.
• W2103263214 cites W1969662492 @default.
• W2103263214 cites W1970540273 @default.
• W2103263214 cites W1972462453 @default.
• W2103263214 cites W1979602030 @default.
• W2103263214 cites W1981542773 @default.
• W2103263214 cites W1990764711 @default.
• W2103263214 cites W1990970431 @default.
• W2103263214 cites W1991042974 @default.
• W2103263214 cites W1993339149 @default.
• W2103263214 cites W1993777936 @default.
• W2103263214 cites W2001760749 @default.
• W2103263214 cites W2009460260 @default.
• W2103263214 cites W2014659929 @default.
• W2103263214 cites W2017311227 @default.
• W2103263214 cites W2018748428 @default.
• W2103263214 cites W2020226128 @default.
• W2103263214 cites W2026978831 @default.
• W2103263214 cites W2031471582 @default.
• W2103263214 cites W2036760386 @default.
• W2103263214 cites W2038398176 @default.
• W2103263214 cites W2040857345 @default.
• W2103263214 cites W2043668331 @default.
• W2103263214 cites W2046514713 @default.
• W2103263214 cites W2047415520 @default.
• W2103263214 cites W2048525783 @default.
• W2103263214 cites W2048540775 @default.
• W2103263214 cites W2055420093 @default.
• W2103263214 cites W2057717787 @default.
• W2103263214 cites W2062745645 @default.
• W2103263214 cites W2064292804 @default.
• W2103263214 cites W2080455187 @default.
• W2103263214 cites W2088905867 @default.
• W2103263214 cites W2094341284 @default.
• W2103263214 cites W2097641177 @default.
• W2103263214 cites W2100806280 @default.
• W2103263214 cites W2104835091 @default.
• W2103263214 cites W2416660636 @default.
• W2103263214 cites W2427446498 @default.
• W2103263214 doi "https://doi.org/10.1016/s0009-9236(97)90138-7" @default.
• W2103263214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9164420" @default.
• W2103263214 hasPublicationYear "1997" @default.
• W2103263214 type Work @default.
• W2103263214 sameAs 2103263214 @default.
• W2103263214 citedByCount "77" @default.
• W2103263214 countsByYear W21032632142012 @default.
• W2103263214 countsByYear W21032632142013 @default.
• W2103263214 countsByYear W21032632142014 @default.
• W2103263214 countsByYear W21032632142015 @default.
• W2103263214 countsByYear W21032632142016 @default.
• W2103263214 countsByYear W21032632142017 @default.
• W2103263214 countsByYear W21032632142019 @default.
• W2103263214 countsByYear W21032632142020 @default.
• W2103263214 crossrefType "journal-article" @default.
• W2103263214 hasAuthorship W2103263214A5007495122 @default.
• W2103263214 hasAuthorship W2103263214A5015017045 @default.
• W2103263214 hasAuthorship W2103263214A5021151100 @default.
• W2103263214 hasAuthorship W2103263214A5054404247 @default.
• W2103263214 hasAuthorship W2103263214A5054781284 @default.
• W2103263214 hasAuthorship W2103263214A5067571671 @default.
• W2103263214 hasAuthorship W2103263214A5081525159 @default.
• W2103263214 hasAuthorship W2103263214A5082232461 @default.
• W2103263214 hasConcept C118487528 @default.
• W2103263214 hasConcept C118552586 @default.
• W2103263214 hasConcept C126322002 @default.
• W2103263214 hasConcept C158846371 @default.
• W2103263214 hasConcept C178853913 @default.
• W2103263214 hasConcept C2775926640 @default.
• W2103263214 hasConcept C2777204577 @default.
• W2103263214 hasConcept C2778073030 @default.
• W2103263214 hasConcept C2778186239 @default.
• W2103263214 hasConcept C2778527774 @default.
• W2103263214 hasConcept C2779108703 @default.
• W2103263214 hasConcept C2779735895 @default.
• W2103263214 hasConcept C2779938033 @default.
• W2103263214 hasConcept C2780662894 @default.
• W2103263214 hasConcept C42219234 @default.
• W2103263214 hasConcept C71924100 @default.
• W2103263214 hasConceptScore W2103263214C118487528 @default.
• W2103263214 hasConceptScore W2103263214C118552586 @default.
• W2103263214 hasConceptScore W2103263214C126322002 @default.
• W2103263214 hasConceptScore W2103263214C158846371 @default.
• W2103263214 hasConceptScore W2103263214C178853913 @default.
• W2103263214 hasConceptScore W2103263214C2775926640 @default.
• W2103263214 hasConceptScore W2103263214C2777204577 @default.

• next