FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103263790> ?p ?o ?g. }

• W2103263790 endingPage "83" @default.
• W2103263790 startingPage "74" @default.
• W2103263790 abstract "The autoimmune regulator (AIRE) protein is a key mediator of the central tolerance for tissue specific antigens and is involved in transcriptional control of many antigens in thymic medullary epithelial cells (mTEC). Mutations in the AIRE gene cause a rare disease named autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Here we report using GST pull-down assay, mass-spectrometry and co-immunoprecipitation that a heterotrimeric complex of DNA-Dependent Protein Kinase (DNA-PK), consisting of Ku70, Ku80 and DNA-PK catalytic subunit (DNA-PKcs), is a novel interaction partner for AIRE. In vitro phosphorylation assays show that the residues Thr68 and Ser156 are DNA-PK phosphorylation sites in AIRE. In addition, we demonstrate that DNA-PKcs is expressed in AIRE positive mTEC cell population and that introduction of mutations into the AIRE phosphorylation sites decrease the capacity of AIRE to activate transcription from reporter promoters. In conclusion, our results suggest that phosphorylation of the AIRE protein at Thr68 and Ser156 by DNA-PK influences AIRE transactivation ability and might have impact on other aspects of the functional regulation of the AIRE protein." @default.
• W2103263790 created "2016-06-24" @default.
• W2103263790 creator A5017976977 @default.
• W2103263790 creator A5026469169 @default.
• W2103263790 creator A5058803059 @default.
• W2103263790 creator A5062841765 @default.
• W2103263790 creator A5067888978 @default.
• W2103263790 creator A5070840104 @default.
• W2103263790 creator A5071992317 @default.
• W2103263790 creator A5074836503 @default.
• W2103263790 creator A5077072222 @default.
• W2103263790 creator A5085086527 @default.
• W2103263790 creator A5085615386 @default.
• W2103263790 date "2008-01-01" @default.
• W2103263790 modified "2023-10-18" @default.
• W2103263790 title "DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity" @default.
• W2103263790 cites W1561092615 @default.
• W2103263790 cites W1809586716 @default.
• W2103263790 cites W1963613246 @default.
• W2103263790 cites W1963696308 @default.
• W2103263790 cites W1964659850 @default.
• W2103263790 cites W1977145510 @default.
• W2103263790 cites W1999206490 @default.
• W2103263790 cites W2004282938 @default.
• W2103263790 cites W2007635472 @default.
• W2103263790 cites W2014225480 @default.
• W2103263790 cites W2014593047 @default.
• W2103263790 cites W2015707695 @default.
• W2103263790 cites W2016539997 @default.
• W2103263790 cites W2022807116 @default.
• W2103263790 cites W2028222510 @default.
• W2103263790 cites W2030763718 @default.
• W2103263790 cites W2037014669 @default.
• W2103263790 cites W2038163496 @default.
• W2103263790 cites W2041943150 @default.
• W2103263790 cites W2041944666 @default.
• W2103263790 cites W2051346727 @default.
• W2103263790 cites W2056070148 @default.
• W2103263790 cites W2057996726 @default.
• W2103263790 cites W2063683246 @default.
• W2103263790 cites W2063733110 @default.
• W2103263790 cites W2064792501 @default.
• W2103263790 cites W2065446100 @default.
• W2103263790 cites W2075358112 @default.
• W2103263790 cites W2076023322 @default.
• W2103263790 cites W2083737302 @default.
• W2103263790 cites W2085037886 @default.
• W2103263790 cites W2085567045 @default.
• W2103263790 cites W2087688041 @default.
• W2103263790 cites W2092355759 @default.
• W2103263790 cites W2098589211 @default.
• W2103263790 cites W2098952156 @default.
• W2103263790 cites W2102419722 @default.
• W2103263790 cites W2106850730 @default.
• W2103263790 cites W2113833115 @default.
• W2103263790 cites W2125057960 @default.
• W2103263790 cites W2125540086 @default.
• W2103263790 cites W2125679885 @default.
• W2103263790 cites W2130728712 @default.
• W2103263790 cites W2132511528 @default.
• W2103263790 cites W2145554419 @default.
• W2103263790 cites W2155303282 @default.
• W2103263790 cites W2160127445 @default.
• W2103263790 cites W2165214298 @default.
• W2103263790 cites W4250719896 @default.
• W2103263790 doi "https://doi.org/10.1016/j.bbamcr.2007.09.003" @default.
• W2103263790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2225445" @default.
• W2103263790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997173" @default.
• W2103263790 hasPublicationYear "2008" @default.
• W2103263790 type Work @default.
• W2103263790 sameAs 2103263790 @default.
• W2103263790 citedByCount "62" @default.
• W2103263790 countsByYear W21032637902012 @default.
• W2103263790 countsByYear W21032637902013 @default.
• W2103263790 countsByYear W21032637902014 @default.
• W2103263790 countsByYear W21032637902015 @default.
• W2103263790 countsByYear W21032637902016 @default.
• W2103263790 countsByYear W21032637902017 @default.
• W2103263790 countsByYear W21032637902018 @default.
• W2103263790 countsByYear W21032637902019 @default.
• W2103263790 countsByYear W21032637902021 @default.
• W2103263790 countsByYear W21032637902022 @default.
• W2103263790 crossrefType "journal-article" @default.
• W2103263790 hasAuthorship W2103263790A5017976977 @default.
• W2103263790 hasAuthorship W2103263790A5026469169 @default.
• W2103263790 hasAuthorship W2103263790A5058803059 @default.
• W2103263790 hasAuthorship W2103263790A5062841765 @default.
• W2103263790 hasAuthorship W2103263790A5067888978 @default.
• W2103263790 hasAuthorship W2103263790A5070840104 @default.
• W2103263790 hasAuthorship W2103263790A5071992317 @default.
• W2103263790 hasAuthorship W2103263790A5074836503 @default.
• W2103263790 hasAuthorship W2103263790A5077072222 @default.
• W2103263790 hasAuthorship W2103263790A5085086527 @default.
• W2103263790 hasAuthorship W2103263790A5085615386 @default.
• W2103263790 hasBestOaLocation W21032637901 @default.
• W2103263790 hasConcept C104292427 @default.
• W2103263790 hasConcept C104317684 @default.
• W2103263790 hasConcept C11960822 @default.

• next