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• W2103264326 abstract "Exogenous proline can protect cells of Saccharomyces cerevisiae from oxidative stress. We altered intracellular proline levels by overexpressing the proline dehydrogenase gene (PUT1) of S. cerevisiae. Put1p performs the first enzymatic step of proline degradation in S. cerevisiae. Overexpression of Put1p results in low proline levels and hypersensitivity to oxidants, such as hydrogen peroxide and paraquat. A put1-disrupted yeast mutant deficient in Put1p activity has increased protection from oxidative stress and increased proline levels. Following a conditional life/death screen in yeast, we identified a tomato (Lycopersicon esculentum) gene encoding a QM-like protein (tQM) and found that stable expression of tQM in the Put1p-overexpressing strain conferred protection against oxidative damage from H2O2, paraquat, and heat. This protection was correlated with reactive oxygen species (ROS) reduction and increased proline accumulation. A yeast two-hybrid system assay was used to show that tQM physically interacts with Put1p in yeast, suggesting that tQM is directly involved in modulating proline levels. tQM also can rescue yeast from the lethality mediated by the mammalian proapoptotic protein Bax, through the inhibition of ROS generation. Our results suggest that tQM is a component of various stress response pathways and may function in proline-mediated stress tolerance in plants." @default.
• W2103264326 created "2016-06-24" @default.
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• W2103264326 date "2006-06-01" @default.
• W2103264326 modified "2023-10-16" @default.
• W2103264326 title "Tomato QM-Like Protein Protects <i>Saccharomyces cerevisiae</i> Cells against Oxidative Stress by Regulating Intracellular Proline Levels" @default.
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• W2103264326 doi "https://doi.org/10.1128/aem.02428-05" @default.
• W2103264326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1489650" @default.
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