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- W2103264551 abstract "Tissue engineering is an application for gene therapy that is in its infancy. We show that simple liposomal-mediated gene transfer could result in a potentially useful biological effect in the field of wound healing. cDNA encoding the 165 amino acid form of vascular endothelial growth factor complexed to commercially available liposomes was injected into rat skin 1 week before raising a random pattern 3 x 10 cm flap. The flap survival was enhanced by 14 percent, and was accomplished without accessing the arterial inflow of the territory. These results were statistically significant (p<0.002) and reproducible. No adverse effects were seen. Histological analysis of the angiogenesis localized much of the new vessel formation to the area around the hair follicles. Polymerase chain reaction amplification of extracted flap tissue confirmed the presence of the transgene." @default.
- W2103264551 created "2016-06-24" @default.
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- W2103264551 date "2004-03-01" @default.
- W2103264551 modified "2023-09-26" @default.
- W2103264551 title "Genomic analysis of insulin-like growth factor-I gene transfer in thermally injured rats" @default.
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- W2103264551 doi "https://doi.org/10.1111/j.1067-1927.2004.012114.x" @default.
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