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• W2103265007 abstract "<b>Background:</b> High frequency stimulation of the subthalamic nucleus (STN) is an alternative but expensive neurosurgical treatment for parkinsonian patients with levodopa induced motor complications. <b>Objective:</b> To assess the safety, clinical effects, quality of life, and economic cost of STN stimulation. <b>Methods:</b> We conducted a prospective multicentre study in 95 consecutive Parkinson’s disease (PD) patients receiving bilateral STN stimulation and assessed its effects over 12 months. A double blind randomised motor evaluation was carried out at 3 month follow up, and quality of life, self care ability, and predictive factors of outcome following surgery were assessed. The cost of PD was estimated over 6 months before and after surgery. <b>Results:</b> The Unified Parkinson’s Disease Rating Scale (UPDRS) motor score improved by 57% (p<0.0001) and activities of daily living improved by 48% (p<0.0001) at 12 month follow up. Double blind motor scoring improved by 51% at 3 month follow up (p<0.0001). The total PD Quality of Life Questionnaire (PDQL-37) score improved by 28% (p<0.001). The better the preoperative motor score after a levodopa challenge, the better the outcome after STN stimulation. Five patients developed an intracerebral haematoma during electrode implantation with permanent after effects in two. The 6 month costs of PD decreased from €10 087 before surgery to €1673 after surgery (p<0.0001) mainly because of the decrease in medication. These savings allowed a return on the procedure investment, estimated at €36 904 over 2.2 years. <b>Conclusions:</b> STN stimulation has good outcomes with relatively low risk and little cost burden in PD patients with levodopa induced motor complications." @default.
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• W2103265007 date "2006-04-01" @default.
• W2103265007 modified "2023-10-03" @default.
• W2103265007 title "Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson's disease" @default.
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• W2103265007 doi "https://doi.org/10.1136/jnnp.2005.077677" @default.
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