FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103267467> ?p ?o ?g. }

• W2103267467 endingPage "822" @default.
• W2103267467 startingPage "814" @default.
• W2103267467 abstract "Dietary soluble-fiber sources such as pectin, guar gum, or psyllium decrease plasma concentrations of low-density-lipoprotein (LDL) cholesterol in guinea pigs by distinct mechanisms, including increases in LDL apolipoprotein (apo) B turnover and/or decreases in LDL apo B flux (J Lipid Res 1995; 36:2394-404). The present studies were undertaken to test whether changes in the rates of very-low-density lipoprotein (VLDL) apo B secretion, VLDL conversion to LDL, and hepatic uptake of VLDL were related to the cholesterol-lowering actions of these soluble fibers. Guinea pigs were fed (by wt) 12.5% pectin, 12.5% guar gum, 7.5% psyllium, or a control diet containing cellulose as the fiber source. Plasma cholesterol concentrations were significantly lower in guinea pigs fed pectin, guar gum, and psyllium by 42%, 46%, and 35%, respectively (P < 0.001), compared with those animals fed the control diet, whereas plasma triacylglycerol concentrations were lower only with guar gum intake. The secretion rate of triacylglycerol, determined after Triton was injected to block VLDL catabolism, was not different among dietary treatment groups whereas the secretion rate of apo B was lower with pectin, guar gum, and psyllium intakes (P < 0.01). In addition, pectin, guar gum, and psyllium significantly altered the composition of newly secreted VLDLs by increasing the number of triacylglycerol and phospholipid molecules in the secreted lipoprotein, indicating the presence of larger nascent VLDLs. In contrast, the average particle diameter of mature VLDLs as determined by electron microscopy was smaller in the dietary soluble-fiber groups in the following order: pectin < psyllium < guar gum. Plasma lecithin-cholesteryl acyltransferase and cholesteryl ester transfer protein activities were lower with intake of pectin, guar gum, and psyllium (P < 0.01). Injection of radiolabeled lipoproteins indicated that pectin, guar gum, and psyllium intakes resulted in more rapid VLDL and LDL apo B turnover and lower LDL apo B flux in guinea pigs fed guar gum and psyllium. These results suggest that the secretion rate of apo B, compositional changes in lipoproteins occurring in the intravascular compartment, and up-regulation of LDL receptors-associated with faster LDL apo B turnover rates-are secondary metabolic responses induced by dietary fiber that contribute to the lowering of plasma cholesterol concentrations." @default.
• W2103267467 created "2016-06-24" @default.
• W2103267467 creator A5010008962 @default.
• W2103267467 creator A5017102102 @default.
• W2103267467 creator A5048003341 @default.
• W2103267467 creator A5062254214 @default.
• W2103267467 creator A5071905851 @default.
• W2103267467 date "1997-03-01" @default.
• W2103267467 modified "2023-10-16" @default.
• W2103267467 title "Regulation of apolipoprotein B-containing lipoproteins by dietary soluble fiber in guinea pigs" @default.
• W2103267467 cites W1029596508 @default.
• W2103267467 cites W1522459970 @default.
• W2103267467 cites W1688516642 @default.
• W2103267467 cites W1769373082 @default.
• W2103267467 cites W1802945163 @default.
• W2103267467 cites W1850775144 @default.
• W2103267467 cites W1860487341 @default.
• W2103267467 cites W1883947525 @default.
• W2103267467 cites W1908151677 @default.
• W2103267467 cites W192989025 @default.
• W2103267467 cites W1932697646 @default.
• W2103267467 cites W1946263363 @default.
• W2103267467 cites W1946753905 @default.
• W2103267467 cites W1962222666 @default.
• W2103267467 cites W1964386483 @default.
• W2103267467 cites W1986988638 @default.
• W2103267467 cites W2017234187 @default.
• W2103267467 cites W2019182166 @default.
• W2103267467 cites W2020026043 @default.
• W2103267467 cites W2031423487 @default.
• W2103267467 cites W2035329305 @default.
• W2103267467 cites W2040013771 @default.
• W2103267467 cites W2051107826 @default.
• W2103267467 cites W2057484292 @default.
• W2103267467 cites W2073403739 @default.
• W2103267467 cites W2075656513 @default.
• W2103267467 cites W2077780493 @default.
• W2103267467 cites W2080888232 @default.
• W2103267467 cites W2097627092 @default.
• W2103267467 cites W2109478287 @default.
• W2103267467 cites W2119032182 @default.
• W2103267467 cites W2124568381 @default.
• W2103267467 cites W2125042127 @default.
• W2103267467 cites W2125292228 @default.
• W2103267467 cites W2136082672 @default.
• W2103267467 cites W2146579215 @default.
• W2103267467 cites W2165799945 @default.
• W2103267467 cites W2185638699 @default.
• W2103267467 cites W2214593217 @default.
• W2103267467 cites W2267781679 @default.
• W2103267467 cites W2311904674 @default.
• W2103267467 cites W2395102160 @default.
• W2103267467 cites W2407480007 @default.
• W2103267467 cites W2417058886 @default.
• W2103267467 cites W4243946355 @default.
• W2103267467 doi "https://doi.org/10.1093/ajcn/65.3.814" @default.
• W2103267467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9062534" @default.
• W2103267467 hasPublicationYear "1997" @default.
• W2103267467 type Work @default.
• W2103267467 sameAs 2103267467 @default.
• W2103267467 citedByCount "52" @default.
• W2103267467 countsByYear W21032674672012 @default.
• W2103267467 countsByYear W21032674672013 @default.
• W2103267467 countsByYear W21032674672016 @default.
• W2103267467 countsByYear W21032674672017 @default.
• W2103267467 countsByYear W21032674672018 @default.
• W2103267467 countsByYear W21032674672019 @default.
• W2103267467 countsByYear W21032674672023 @default.
• W2103267467 crossrefType "journal-article" @default.
• W2103267467 hasAuthorship W2103267467A5010008962 @default.
• W2103267467 hasAuthorship W2103267467A5017102102 @default.
• W2103267467 hasAuthorship W2103267467A5048003341 @default.
• W2103267467 hasAuthorship W2103267467A5062254214 @default.
• W2103267467 hasAuthorship W2103267467A5071905851 @default.
• W2103267467 hasBestOaLocation W21032674671 @default.
• W2103267467 hasConcept C126322002 @default.
• W2103267467 hasConcept C134018914 @default.
• W2103267467 hasConcept C185592680 @default.
• W2103267467 hasConcept C2776551768 @default.
• W2103267467 hasConcept C2776725572 @default.
• W2103267467 hasConcept C2778163477 @default.
• W2103267467 hasConcept C2779372120 @default.
• W2103267467 hasConcept C2780072125 @default.
• W2103267467 hasConcept C2780756937 @default.
• W2103267467 hasConcept C2992741425 @default.
• W2103267467 hasConcept C31903555 @default.
• W2103267467 hasConcept C55493867 @default.
• W2103267467 hasConcept C62746215 @default.
• W2103267467 hasConcept C71924100 @default.
• W2103267467 hasConcept C8243546 @default.
• W2103267467 hasConcept C86803240 @default.
• W2103267467 hasConceptScore W2103267467C126322002 @default.
• W2103267467 hasConceptScore W2103267467C134018914 @default.
• W2103267467 hasConceptScore W2103267467C185592680 @default.
• W2103267467 hasConceptScore W2103267467C2776551768 @default.
• W2103267467 hasConceptScore W2103267467C2776725572 @default.
• W2103267467 hasConceptScore W2103267467C2778163477 @default.
• W2103267467 hasConceptScore W2103267467C2779372120 @default.

• next