FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103268923> ?p ?o ?g. }

• W2103268923 endingPage "1687" @default.
• W2103268923 startingPage "1680" @default.
• W2103268923 abstract "ABSTRACT The activities of mefloquine (MFL) and related compounds against previously characterized Streptococcus pneumoniae strains carrying defined amino acid substitutions in the c subunit of the F 0 F 1 H + -ATPase were studied. In addition, a series of MFL-resistant (Mfl r ) strains were isolated and characterized. A good correlation was observed between inhibition of growth and inhibition of the membrane-associated F 0 F 1 H + -ATPase activity. MFL was about 10-fold more active than optochin and about 200-fold more active than quinine in inhibiting both the growth and the ATPase activities of laboratory pneumococcal strain R6. Mutant strains were inhibited by the different compounds to different degrees, depending on their specific mutations in the c subunit. The resistant strains studied had point mutations that changed amino acid residues in either the c subunit or the a subunit of the F 0 complex. Changes in the c subunit were located in one of the two transmembrane α helices: residues M13, G14, G20, M23, and N24 of helix 1 and residues M44, G47, V48, A49, and V57 of helix 2. Changes in the a subunit were also found in either of the transmembrane α helices, helix 5 or 6: residue L186 of helix 5 and residues W206, F209, and S214 of helix 6. These results suggest that the transmembrane helices of the c and a subunits interact and that the mutated residues are important for the structure of the F 0 complex and proton translocation." @default.
• W2103268923 created "2016-06-24" @default.
• W2103268923 creator A5043084485 @default.
• W2103268923 creator A5045527000 @default.
• W2103268923 creator A5046206757 @default.
• W2103268923 creator A5059354705 @default.
• W2103268923 date "2002-06-01" @default.
• W2103268923 modified "2023-10-16" @default.
• W2103268923 title "Mefloquine and New Related Compounds Target the F ₀ Complex of the F ₀ F ₁ H ⁺ -ATPase of <i>Streptococcus pneumoniae</i>" @default.
• W2103268923 cites W1492598749 @default.
• W2103268923 cites W1499450468 @default.
• W2103268923 cites W1526754730 @default.
• W2103268923 cites W1539968788 @default.
• W2103268923 cites W1560004875 @default.
• W2103268923 cites W1596316759 @default.
• W2103268923 cites W1869724171 @default.
• W2103268923 cites W1964051078 @default.
• W2103268923 cites W1969830416 @default.
• W2103268923 cites W1985818354 @default.
• W2103268923 cites W1994057372 @default.
• W2103268923 cites W2010704689 @default.
• W2103268923 cites W2053804813 @default.
• W2103268923 cites W2071950147 @default.
• W2103268923 cites W2106746976 @default.
• W2103268923 cites W2115834151 @default.
• W2103268923 cites W2119615612 @default.
• W2103268923 cites W2129683367 @default.
• W2103268923 cites W2131209218 @default.
• W2103268923 cites W2140583034 @default.
• W2103268923 cites W2140725652 @default.
• W2103268923 cites W2146545831 @default.
• W2103268923 cites W2151957387 @default.
• W2103268923 cites W2156803384 @default.
• W2103268923 cites W2167548878 @default.
• W2103268923 cites W2318532494 @default.
• W2103268923 cites W2331102377 @default.
• W2103268923 cites W2336287850 @default.
• W2103268923 doi "https://doi.org/10.1128/aac.46.6.1680-1687.2002" @default.
• W2103268923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/127268" @default.
• W2103268923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12019076" @default.
• W2103268923 hasPublicationYear "2002" @default.
• W2103268923 type Work @default.
• W2103268923 sameAs 2103268923 @default.
• W2103268923 citedByCount "48" @default.
• W2103268923 countsByYear W21032689232012 @default.
• W2103268923 countsByYear W21032689232013 @default.
• W2103268923 countsByYear W21032689232014 @default.
• W2103268923 countsByYear W21032689232015 @default.
• W2103268923 countsByYear W21032689232016 @default.
• W2103268923 countsByYear W21032689232017 @default.
• W2103268923 countsByYear W21032689232019 @default.
• W2103268923 countsByYear W21032689232020 @default.
• W2103268923 countsByYear W21032689232021 @default.
• W2103268923 countsByYear W21032689232022 @default.
• W2103268923 countsByYear W21032689232023 @default.
• W2103268923 crossrefType "journal-article" @default.
• W2103268923 hasAuthorship W2103268923A5043084485 @default.
• W2103268923 hasAuthorship W2103268923A5045527000 @default.
• W2103268923 hasAuthorship W2103268923A5046206757 @default.
• W2103268923 hasAuthorship W2103268923A5059354705 @default.
• W2103268923 hasBestOaLocation W21032689231 @default.
• W2103268923 hasConcept C104292427 @default.
• W2103268923 hasConcept C104317684 @default.
• W2103268923 hasConcept C118892022 @default.
• W2103268923 hasConcept C143065580 @default.
• W2103268923 hasConcept C170493617 @default.
• W2103268923 hasConcept C181199279 @default.
• W2103268923 hasConcept C185592680 @default.
• W2103268923 hasConcept C18903297 @default.
• W2103268923 hasConcept C23265538 @default.
• W2103268923 hasConcept C24530287 @default.
• W2103268923 hasConcept C2778530040 @default.
• W2103268923 hasConcept C2779965526 @default.
• W2103268923 hasConcept C515207424 @default.
• W2103268923 hasConcept C55493867 @default.
• W2103268923 hasConcept C71240020 @default.
• W2103268923 hasConcept C86803240 @default.
• W2103268923 hasConceptScore W2103268923C104292427 @default.
• W2103268923 hasConceptScore W2103268923C104317684 @default.
• W2103268923 hasConceptScore W2103268923C118892022 @default.
• W2103268923 hasConceptScore W2103268923C143065580 @default.
• W2103268923 hasConceptScore W2103268923C170493617 @default.
• W2103268923 hasConceptScore W2103268923C181199279 @default.
• W2103268923 hasConceptScore W2103268923C185592680 @default.
• W2103268923 hasConceptScore W2103268923C18903297 @default.
• W2103268923 hasConceptScore W2103268923C23265538 @default.
• W2103268923 hasConceptScore W2103268923C24530287 @default.
• W2103268923 hasConceptScore W2103268923C2778530040 @default.
• W2103268923 hasConceptScore W2103268923C2779965526 @default.
• W2103268923 hasConceptScore W2103268923C515207424 @default.
• W2103268923 hasConceptScore W2103268923C55493867 @default.
• W2103268923 hasConceptScore W2103268923C71240020 @default.
• W2103268923 hasConceptScore W2103268923C86803240 @default.
• W2103268923 hasIssue "6" @default.
• W2103268923 hasLocation W21032689231 @default.
• W2103268923 hasLocation W21032689232 @default.
• W2103268923 hasLocation W21032689233 @default.
• W2103268923 hasLocation W21032689234 @default.

• next