FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103272567> ?p ?o ?g. }

• W2103272567 endingPage "1124" @default.
• W2103272567 startingPage "1118" @default.
• W2103272567 abstract "Abstract Rodents typically demonstrate strain-specific susceptibilities to induced autoimmune models such as experimental arthritis and encephalomyelitis. A common feature of the local pathology of these diseases is an extensive infiltration of activated macrophages (MΦ). Different functional activation states can be induced in MΦ during innate immune activation, and it is this differential activation that might be important in susceptibility/resistance to induction or perpetuation of autoimmunity. In this study, we present an extensive, comparative analysis of the activation phenotypes of MΦ derived from autoimmune-susceptible and autoimmune-resistant rat strains to describe a cellular phenotype that defines the disease phenotype. We included investigation of receptor function, intracellular signaling pathways, cytokines, and other soluble mediators released after activation of cells using a panel of stimuli embracing many activation routes. We report that activation of MΦ from the autoimmune-susceptible strain was associated with alternative activation indicated by induction of arginase activity, a lower production of classical proinflammatory mediators, and a high production of interleukin (IL)-23, and MΦ from the autoimmune-resistant strains were associated with a higher production of proinflammatory mediators, a classical activation phenotype, and preferential induction of IL-12. These MΦ phenotypes thus reflect disparate, genetic cellular programs that define autoimmune susceptibility." @default.
• W2103272567 created "2016-06-24" @default.
• W2103272567 creator A5012427776 @default.
• W2103272567 creator A5046682618 @default.
• W2103272567 creator A5070429859 @default.
• W2103272567 creator A5075168559 @default.
• W2103272567 creator A5082855062 @default.
• W2103272567 date "2004-09-15" @default.
• W2103272567 modified "2023-10-02" @default.
• W2103272567 title "Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility" @default.
• W2103272567 cites W1544783432 @default.
• W2103272567 cites W1900649416 @default.
• W2103272567 cites W1938744071 @default.
• W2103272567 cites W1970456030 @default.
• W2103272567 cites W1978068134 @default.
• W2103272567 cites W1981775064 @default.
• W2103272567 cites W1987244469 @default.
• W2103272567 cites W1994723172 @default.
• W2103272567 cites W2005745206 @default.
• W2103272567 cites W2013227563 @default.
• W2103272567 cites W2025521783 @default.
• W2103272567 cites W2045833339 @default.
• W2103272567 cites W2046508329 @default.
• W2103272567 cites W2056834558 @default.
• W2103272567 cites W2072441482 @default.
• W2103272567 cites W2075727474 @default.
• W2103272567 cites W2076889715 @default.
• W2103272567 cites W2079276179 @default.
• W2103272567 cites W2082062343 @default.
• W2103272567 cites W2085853581 @default.
• W2103272567 cites W2087905758 @default.
• W2103272567 cites W2090197666 @default.
• W2103272567 cites W2094942816 @default.
• W2103272567 cites W2101331467 @default.
• W2103272567 cites W2102938005 @default.
• W2103272567 cites W2107664859 @default.
• W2103272567 cites W2113577022 @default.
• W2103272567 cites W2116828514 @default.
• W2103272567 cites W2125751904 @default.
• W2103272567 cites W2129389823 @default.
• W2103272567 cites W2136382214 @default.
• W2103272567 cites W2136415390 @default.
• W2103272567 cites W2138064547 @default.
• W2103272567 cites W2143043043 @default.
• W2103272567 cites W2151363901 @default.
• W2103272567 cites W2151948277 @default.
• W2103272567 cites W2153274751 @default.
• W2103272567 cites W2163175900 @default.
• W2103272567 cites W2405406971 @default.
• W2103272567 cites W4232696887 @default.
• W2103272567 doi "https://doi.org/10.1189/jlb.0704385" @default.
• W2103272567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15371491" @default.
• W2103272567 hasPublicationYear "2004" @default.
• W2103272567 type Work @default.
• W2103272567 sameAs 2103272567 @default.
• W2103272567 citedByCount "45" @default.
• W2103272567 countsByYear W21032725672012 @default.
• W2103272567 countsByYear W21032725672013 @default.
• W2103272567 countsByYear W21032725672014 @default.
• W2103272567 countsByYear W21032725672015 @default.
• W2103272567 countsByYear W21032725672016 @default.
• W2103272567 countsByYear W21032725672017 @default.
• W2103272567 countsByYear W21032725672020 @default.
• W2103272567 countsByYear W21032725672022 @default.
• W2103272567 crossrefType "journal-article" @default.
• W2103272567 hasAuthorship W2103272567A5012427776 @default.
• W2103272567 hasAuthorship W2103272567A5046682618 @default.
• W2103272567 hasAuthorship W2103272567A5070429859 @default.
• W2103272567 hasAuthorship W2103272567A5075168559 @default.
• W2103272567 hasAuthorship W2103272567A5082855062 @default.
• W2103272567 hasBestOaLocation W21032725671 @default.
• W2103272567 hasConcept C104317684 @default.
• W2103272567 hasConcept C127716648 @default.
• W2103272567 hasConcept C136449434 @default.
• W2103272567 hasConcept C159654299 @default.
• W2103272567 hasConcept C164027704 @default.
• W2103272567 hasConcept C203014093 @default.
• W2103272567 hasConcept C2776914184 @default.
• W2103272567 hasConcept C2778486448 @default.
• W2103272567 hasConcept C2779075594 @default.
• W2103272567 hasConcept C2780130043 @default.
• W2103272567 hasConcept C54355233 @default.
• W2103272567 hasConcept C86803240 @default.
• W2103272567 hasConcept C8891405 @default.
• W2103272567 hasConcept C95444343 @default.
• W2103272567 hasConceptScore W2103272567C104317684 @default.
• W2103272567 hasConceptScore W2103272567C127716648 @default.
• W2103272567 hasConceptScore W2103272567C136449434 @default.
• W2103272567 hasConceptScore W2103272567C159654299 @default.
• W2103272567 hasConceptScore W2103272567C164027704 @default.
• W2103272567 hasConceptScore W2103272567C203014093 @default.
• W2103272567 hasConceptScore W2103272567C2776914184 @default.
• W2103272567 hasConceptScore W2103272567C2778486448 @default.
• W2103272567 hasConceptScore W2103272567C2779075594 @default.
• W2103272567 hasConceptScore W2103272567C2780130043 @default.
• W2103272567 hasConceptScore W2103272567C54355233 @default.
• W2103272567 hasConceptScore W2103272567C86803240 @default.
• W2103272567 hasConceptScore W2103272567C8891405 @default.

• next