Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103280877> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2103280877 endingPage "178" @default.
- W2103280877 startingPage "172" @default.
- W2103280877 abstract "RNA from circulating blood reticulocytes was utilized to provide a robust description of genes transcribed at the final stages of erythroblast maturation. After depletion of leukocytes and platelets, Affymetrix HG-U133 arrays were hybridized with probe generated from the reticulocyte total RNA (blood obtained from 14 umbilical cords and 14 healthy adult humans). Among the cord and adult reticulocyte profiles, 698 probe sets (488 named genes) were detected in each of the 28 samples. Among the highly expressed genes, promoter analyses revealed a subset of transcription factor binding motifs encoded at higher than expected frequencies including the hypoxia-related arylhydrocarbon receptor repressor family. Over 100 probe sets demonstrated differential expression between the cord and adult reticulocyte samples. For verification, the array expression patterns for 21 genes were confirmed by real-time PCR (correlation coefficient 0.98). Only four transcripts (MAP17, FLJ32009 , ARRB2, and FLJ27365 ) were identified as being upregulated in the adult blood transcriptome. Further analysis revealed that the lipid-regulating protein MAP17 was present in the membrane fraction of adult erythrocytes, but not detected in cord blood erythrocytes. Combined with other clinical and experimental data, these reticulocyte transcriptome profiles should be useful to better understand the molecular bases of terminal erythroid differentiation, hemoglobin switching, iron metabolism and malarial pathogenesis." @default.
- W2103280877 created "2016-06-24" @default.
- W2103280877 creator A5000169747 @default.
- W2103280877 creator A5004573506 @default.
- W2103280877 creator A5010437305 @default.
- W2103280877 creator A5032746542 @default.
- W2103280877 creator A5033839916 @default.
- W2103280877 creator A5042413628 @default.
- W2103280877 creator A5052306699 @default.
- W2103280877 date "2007-07-01" @default.
- W2103280877 modified "2023-09-26" @default.
- W2103280877 title "The human reticulocyte transcriptome" @default.
- W2103280877 cites W1544769636 @default.
- W2103280877 cites W1967039839 @default.
- W2103280877 cites W1971615450 @default.
- W2103280877 cites W1972998779 @default.
- W2103280877 cites W1978699219 @default.
- W2103280877 cites W1978713358 @default.
- W2103280877 cites W1984271653 @default.
- W2103280877 cites W1988204787 @default.
- W2103280877 cites W1993219568 @default.
- W2103280877 cites W2027816537 @default.
- W2103280877 cites W2032347450 @default.
- W2103280877 cites W2049237667 @default.
- W2103280877 cites W2061050681 @default.
- W2103280877 cites W2080473690 @default.
- W2103280877 cites W2081384247 @default.
- W2103280877 cites W2105619315 @default.
- W2103280877 cites W2138111547 @default.
- W2103280877 cites W2139703939 @default.
- W2103280877 cites W2140488744 @default.
- W2103280877 doi "https://doi.org/10.1152/physiolgenomics.00247.2006" @default.
- W2103280877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17405831" @default.
- W2103280877 hasPublicationYear "2007" @default.
- W2103280877 type Work @default.
- W2103280877 sameAs 2103280877 @default.
- W2103280877 citedByCount "85" @default.
- W2103280877 countsByYear W21032808772012 @default.
- W2103280877 countsByYear W21032808772013 @default.
- W2103280877 countsByYear W21032808772014 @default.
- W2103280877 countsByYear W21032808772015 @default.
- W2103280877 countsByYear W21032808772016 @default.
- W2103280877 countsByYear W21032808772017 @default.
- W2103280877 countsByYear W21032808772018 @default.
- W2103280877 countsByYear W21032808772019 @default.
- W2103280877 countsByYear W21032808772020 @default.
- W2103280877 countsByYear W21032808772021 @default.
- W2103280877 countsByYear W21032808772022 @default.
- W2103280877 countsByYear W21032808772023 @default.
- W2103280877 crossrefType "journal-article" @default.
- W2103280877 hasAuthorship W2103280877A5000169747 @default.
- W2103280877 hasAuthorship W2103280877A5004573506 @default.
- W2103280877 hasAuthorship W2103280877A5010437305 @default.
- W2103280877 hasAuthorship W2103280877A5032746542 @default.
- W2103280877 hasAuthorship W2103280877A5033839916 @default.
- W2103280877 hasAuthorship W2103280877A5042413628 @default.
- W2103280877 hasAuthorship W2103280877A5052306699 @default.
- W2103280877 hasConcept C104317684 @default.
- W2103280877 hasConcept C105580179 @default.
- W2103280877 hasConcept C150194340 @default.
- W2103280877 hasConcept C153911025 @default.
- W2103280877 hasConcept C162317418 @default.
- W2103280877 hasConcept C2778403015 @default.
- W2103280877 hasConcept C54355233 @default.
- W2103280877 hasConcept C86803240 @default.
- W2103280877 hasConcept C95444343 @default.
- W2103280877 hasConceptScore W2103280877C104317684 @default.
- W2103280877 hasConceptScore W2103280877C105580179 @default.
- W2103280877 hasConceptScore W2103280877C150194340 @default.
- W2103280877 hasConceptScore W2103280877C153911025 @default.
- W2103280877 hasConceptScore W2103280877C162317418 @default.
- W2103280877 hasConceptScore W2103280877C2778403015 @default.
- W2103280877 hasConceptScore W2103280877C54355233 @default.
- W2103280877 hasConceptScore W2103280877C86803240 @default.
- W2103280877 hasConceptScore W2103280877C95444343 @default.
- W2103280877 hasIssue "2" @default.
- W2103280877 hasLocation W21032808771 @default.
- W2103280877 hasLocation W21032808772 @default.
- W2103280877 hasOpenAccess W2103280877 @default.
- W2103280877 hasPrimaryLocation W21032808771 @default.
- W2103280877 hasRelatedWork W1523507899 @default.
- W2103280877 hasRelatedWork W1971124177 @default.
- W2103280877 hasRelatedWork W2009966535 @default.
- W2103280877 hasRelatedWork W2092538393 @default.
- W2103280877 hasRelatedWork W2102579905 @default.
- W2103280877 hasRelatedWork W2329658161 @default.
- W2103280877 hasRelatedWork W3089353767 @default.
- W2103280877 hasRelatedWork W3097825150 @default.
- W2103280877 hasRelatedWork W3146618441 @default.
- W2103280877 hasRelatedWork W4247273247 @default.
- W2103280877 hasVolume "30" @default.
- W2103280877 isParatext "false" @default.
- W2103280877 isRetracted "false" @default.
- W2103280877 magId "2103280877" @default.
- W2103280877 workType "article" @default.