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• W2103288730 endingPage "112" @default.
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• W2103288730 abstract "Pancreatic adenocarcinoma remains among the most lethal of human malignancies. Overall 5-y survival is less than 5%, and only 20% of patients presenting with localized disease amenable to surgical resection. Even in patients who undergo resection, long-term survival remains extremely poor. A major contributor to the aggressiveness of multiple cancers, and pancreatic cancer in particular, is the process of epithelial-to-mesenchymal transition (EMT). This review highlights the growing evidence of EMT in pancreatic cancer progression, focusing on the contribution of EMT to the development of cancer stem cells and on interaction of EMT with other pathways central to cancer progression, such as Hedgehog signaling, the K-ras oncogene, and transforming growth factor-beta (TGF-β). We will also discuss EMT-targeting agents currently in development and in clinical trials that may help to reduce the morbidity and mortality associated with pancreatic cancer. Pancreatic adenocarcinoma remains among the most lethal of human malignancies. Overall 5-y survival is less than 5%, and only 20% of patients presenting with localized disease amenable to surgical resection. Even in patients who undergo resection, long-term survival remains extremely poor. A major contributor to the aggressiveness of multiple cancers, and pancreatic cancer in particular, is the process of epithelial-to-mesenchymal transition (EMT). This review highlights the growing evidence of EMT in pancreatic cancer progression, focusing on the contribution of EMT to the development of cancer stem cells and on interaction of EMT with other pathways central to cancer progression, such as Hedgehog signaling, the K-ras oncogene, and transforming growth factor-beta (TGF-β). We will also discuss EMT-targeting agents currently in development and in clinical trials that may help to reduce the morbidity and mortality associated with pancreatic cancer. Correcting the misnomers of epithelial–mesenchymal relationsJournal of Surgical ResearchVol. 182Issue 1PreviewShakespeare wrote, “What’s in a name? That which we call a rose by any other name would smell as sweet.” But what if we called a rose by another name and it was not so sweet? The organic gardener and writer, Colleen Vanderlinden noted that, “Roses, lilacs, lavender, hyacinth—all of these flowers have a scent that just makes you happy to be alive. They inspire perfume makers as well as poets. And then you have [the] corpse flower, skunk cabbage, [and] voodoo lily… . They dare us to come closer and have a look. Full-Text PDF" @default.
• W2103288730 created "2016-06-24" @default.
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• W2103288730 date "2012-03-01" @default.
• W2103288730 modified "2023-10-18" @default.
• W2103288730 title "Contribution of Epithelial-to-Mesenchymal Transition and Cancer Stem Cells to Pancreatic Cancer Progression" @default.
• W2103288730 cites W1565561072 @default.
• W2103288730 cites W1636022999 @default.
• W2103288730 cites W1964081206 @default.
• W2103288730 cites W1964082391 @default.
• W2103288730 cites W1965568527 @default.
• W2103288730 cites W1967245224 @default.
• W2103288730 cites W1969840470 @default.
• W2103288730 cites W1971180788 @default.
• W2103288730 cites W1972736766 @default.
• W2103288730 cites W1976324983 @default.
• W2103288730 cites W1977075884 @default.
• W2103288730 cites W1978337436 @default.
• W2103288730 cites W1985070647 @default.
• W2103288730 cites W1985339653 @default.
• W2103288730 cites W1992429870 @default.
• W2103288730 cites W1992676863 @default.
• W2103288730 cites W1996308303 @default.
• W2103288730 cites W1996488211 @default.
• W2103288730 cites W1997316363 @default.
• W2103288730 cites W2002355858 @default.
• W2103288730 cites W2005224639 @default.
• W2103288730 cites W2006087233 @default.
• W2103288730 cites W2011143322 @default.
• W2103288730 cites W2011566302 @default.
• W2103288730 cites W2014442719 @default.
• W2103288730 cites W2014691022 @default.
• W2103288730 cites W2017905687 @default.
• W2103288730 cites W2019264784 @default.
• W2103288730 cites W2022137080 @default.
• W2103288730 cites W2023427658 @default.
• W2103288730 cites W2027954222 @default.
• W2103288730 cites W2028593825 @default.
• W2103288730 cites W2030199762 @default.
• W2103288730 cites W2031348772 @default.
• W2103288730 cites W2035396934 @default.
• W2103288730 cites W2035617243 @default.
• W2103288730 cites W2035653659 @default.
• W2103288730 cites W2035987476 @default.
• W2103288730 cites W2036776072 @default.
• W2103288730 cites W2036802163 @default.
• W2103288730 cites W2037961348 @default.
• W2103288730 cites W2042198997 @default.
• W2103288730 cites W2043376395 @default.
• W2103288730 cites W2056768114 @default.
• W2103288730 cites W2058763255 @default.
• W2103288730 cites W2059160575 @default.
• W2103288730 cites W2062070329 @default.
• W2103288730 cites W2062983115 @default.
• W2103288730 cites W2064906202 @default.
• W2103288730 cites W2069663132 @default.
• W2103288730 cites W2077462602 @default.
• W2103288730 cites W2082057023 @default.
• W2103288730 cites W2082307198 @default.
• W2103288730 cites W2083381199 @default.
• W2103288730 cites W2086152184 @default.
• W2103288730 cites W2086756946 @default.
• W2103288730 cites W2088107574 @default.
• W2103288730 cites W2091506777 @default.
• W2103288730 cites W2096764577 @default.
• W2103288730 cites W2099598957 @default.
• W2103288730 cites W2100751052 @default.
• W2103288730 cites W2100801124 @default.
• W2103288730 cites W2104374560 @default.
• W2103288730 cites W2107235611 @default.
• W2103288730 cites W2107261560 @default.
• W2103288730 cites W2107441200 @default.
• W2103288730 cites W2107723175 @default.
• W2103288730 cites W2110937119 @default.
• W2103288730 cites W2120381403 @default.
• W2103288730 cites W2120656656 @default.
• W2103288730 cites W2121389240 @default.
• W2103288730 cites W2122441872 @default.
• W2103288730 cites W2125053924 @default.
• W2103288730 cites W2125120607 @default.
• W2103288730 cites W2125923072 @default.
• W2103288730 cites W2126811493 @default.
• W2103288730 cites W2128065481 @default.
• W2103288730 cites W2129063289 @default.
• W2103288730 cites W2129204015 @default.
• W2103288730 cites W2129355962 @default.
• W2103288730 cites W2135205703 @default.
• W2103288730 cites W2140338369 @default.
• W2103288730 cites W2142636026 @default.
• W2103288730 cites W2146324297 @default.
• W2103288730 cites W2147807172 @default.
• W2103288730 cites W2153382986 @default.
• W2103288730 cites W2154568166 @default.
• W2103288730 cites W2154589460 @default.

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